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AFDN afadin, adherens junction formation factor [ Microcebus murinus (gray mouse lemur) ]

Gene ID: 105877867, updated on 13-Mar-2024

Summary

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Gene symbol
AFDN
Gene description
afadin, adherens junction formation factor
See related
Ensembl:ENSMICG00000003571
Gene type
protein coding
RefSeq status
MODEL
Organism
Microcebus murinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
34
Annotation release Status Assembly Chr Location
101 current Mmur_3.0 (GCF_000165445.2) 6 NC_033665.1 (121003361..121116027)
100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012196953.1 (1976152..2093264)

Chromosome 6 - NC_033665.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105877865 Neighboring gene uncharacterized LOC105877866 Neighboring gene uncharacterized LOC105877870 Neighboring gene kinesin family member 25 Neighboring gene uncharacterized LOC105877879

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
afadin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmur_3.0 Primary Assembly

Genomic

  1. NC_033665.1 Reference Mmur_3.0 Primary Assembly

    Range
    121003361..121116027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012776829.2 → XP_012632283.2  afadin isoform X1

    UniProtKB/TrEMBL
    A0A8B7H708, A0A8C5VQA3
    Conserved Domains (6) summary
    cd01781
    Location:206 → 305
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:376 → 458
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:973 → 1056
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:570 → 898
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:1 → 90
    UBQ; Ubiquitin-like proteins
    cl25548
    Location:1473 → 1647
    DUF4670; Domain of unknown function (DUF4670)

  2. XM_012776841.2 → XP_012632295.2  afadin isoform X2

    UniProtKB/TrEMBL
    A0A8B7H709, A0A8C5XBN0
    Conserved Domains (5) summary
    cd01781
    Location:206 → 305
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:376 → 458
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:966 → 1049
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:570 → 891
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:1 → 90
    UBQ; Ubiquitin-like proteins

  3. XM_012776840.2 → XP_012632294.2  afadin isoform X5

    UniProtKB/TrEMBL
    A0A8B7H9I0, A0A8C5XBN0
    Related
    ENSMICP00000003255.3, ENSMICT00000003576.3
    Conserved Domains (6) summary
    cd01781
    Location:205 → 304
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:375 → 457
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:965 → 1048
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:569 → 890
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:1 → 89
    UBQ; Ubiquitin-like proteins
    cl25548
    Location:1465 → 1627
    DUF4670; Domain of unknown function (DUF4670)

  4. XM_020287305.1 → XP_020142894.1  afadin isoform X6

    UniProtKB/TrEMBL
    A0A8B7X5S8, A0A8C5XBN0
    Conserved Domains (5) summary
    cd01781
    Location:205 → 304
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:375 → 457
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:965 → 1048
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:569 → 890
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:1 → 89
    UBQ; Ubiquitin-like proteins

  5. XM_012776837.2 → XP_012632291.2  afadin isoform X3

    UniProtKB/TrEMBL
    A0A8B7H728, A0A8C5VQA3
    Conserved Domains (6) summary
    cd01781
    Location:204 → 303
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:341 → 441
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:949 → 1032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:553 → 874
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:1 → 89
    UBQ; Ubiquitin-like proteins
    cl25548
    Location:1449 → 1623
    DUF4670; Domain of unknown function (DUF4670)

  6. XM_020287304.1 → XP_020142893.1  afadin isoform X4

    UniProtKB/TrEMBL
    A0A8B7X743, A0A8C5XBN0
    Conserved Domains (6) summary
    cd01781
    Location:204 → 303
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:341 → 441
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:949 → 1032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:553 → 874
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:1 → 89
    UBQ; Ubiquitin-like proteins
    cl25548
    Location:1449 → 1611
    DUF4670; Domain of unknown function (DUF4670)

  7. XM_020287306.1 → XP_020142895.1  afadin isoform X8

    UniProtKB/TrEMBL
    A0A8B7X6Y3, A0A8C5XBN0
    Related
    ENSMICP00000037930.1, ENSMICT00000047348.2
    Conserved Domains (6) summary
    cd01781
    Location:204 → 303
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:341 → 441
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:949 → 1032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:553 → 874
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:1 → 89
    UBQ; Ubiquitin-like proteins
    cl25548
    Location:1449 → 1611
    DUF4670; Domain of unknown function (DUF4670)

  8. XM_012776845.2 → XP_012632299.2  afadin isoform X7

    UniProtKB/TrEMBL
    A0A8B7H705, A0A8C6ECL0
    Conserved Domains (5) summary
    cd01781
    Location:205 → 304
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:375 → 457
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:965 → 1048
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:569 → 890
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cl00155
    Location:1 → 89
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version

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