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AFDN afadin, adherens junction formation factor [ Homo sapiens (human) ]

Gene ID: 4301, updated on 3-Nov-2018

Summary

Official Symbol
AFDNprovided by HGNC
Official Full Name
afadin, adherens junction formation factorprovided by HGNC
Primary source
HGNC:HGNC:7137
See related
Ensembl:ENSG00000130396 MIM:159559; Vega:OTTHUMG00000016031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AF6; MLLT4; MLL-AF6; l-afadin
Summary
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
Expression
Ubiquitous expression in esophagus (RPKM 18.5), lung (RPKM 15.9) and 24 other tissues See more
Orthologs

Genomic context

See AFDN in Genome Data Viewer
Location:
6q27
Exon count:
36
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (167826872..167972023)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (168227602..168372703)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1558 Neighboring gene uncharacterized LOC441179 Neighboring gene AFDN divergent transcript Neighboring gene uncharacterized LOC107986673 Neighboring gene uncharacterized LOC100128124 Neighboring gene KIF25 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4 (MLLT4, Afadin) protein is incorporated into HIV-1 Gag virus-like particles PubMed
Tat tat The expression of MLLT4 gene is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
    Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
  • Cell junction organization, organism-specific biosystem (from REACTOME)
    Cell junction organization, organism-specific biosystem
    Cell junction organization
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
    Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34371

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ras GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adherens junction organization TAS
Traceable Author Statement
more info
 
bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell-cell adhesion mediated by cadherin ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell contact zone IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
tight junction IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
afadin
Names
ALL1-fused gene from chromosome 6 protein
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
protein AF-6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029689.1 RefSeqGene

    Range
    5001..150030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040000.2NP_001035089.1  afadin isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has several differences compared to variant 4. The resulting isoform (2) is longer at the N-terminus but has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AB209420, AI271860, AK055689, BE503462, D60168
    Consensus CDS
    CCDS47517.1
    UniProtKB/Swiss-Prot
    P55196
    Related
    ENSP00000375956.3, OTTHUMP00000223317, ENST00000392108.7, OTTHUMT00000372078
    Conserved Domains (5) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
  2. NM_001207008.1NP_001193937.1  afadin isoform 1

    See identical proteins and their annotated locations for NP_001193937.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has multiple differences compared to variant 4. The resulting isoform (1, also known as AF6i3) contains a C-terminal F-actin-binding site and has been shown to be involved in the regulation of epithelial wound closure and intercellular adhesion (PMID:16882694).
    Source sequence(s)
    AB209420, AL049698, AL161973, BE645141, DA200453, DB079271
    Consensus CDS
    CCDS75553.1
    UniProtKB/Swiss-Prot
    P55196
    Related
    ENSP00000375960.2, ENST00000392112.5
    Conserved Domains (5) summary
    cd01781
    Location:246345
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:383483
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00992
    Location:9911073
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15471
    Location:595916
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
  3. NM_001291964.1NP_001278893.1  afadin isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AB621809, AL009178, AL049698, AL161973
    Consensus CDS
    CCDS78199.1
    UniProtKB/Swiss-Prot
    P55196
    UniProtKB/TrEMBL
    A8MQ02, G1UI22
    Related
    ENSP00000355771.3, ENST00000366806.6
    Conserved Domains (5) summary
    cd01781
    Location:206305
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:376458
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:570891
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:9671049
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl00155
    Location:190
    UBQ; Ubiquitin-like proteins
  4. NM_001366319.1NP_001353248.1  afadin isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL009178, AL049698, KT258903
    Conserved Domains (6) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25548
    Location:15171678
    DUF4670; Domain of unknown function (DUF4670)
  5. NM_001366320.1NP_001353249.1  afadin isoform 6

    Status: INFERRED

    Source sequence(s)
    AL009178, AL049698, AL731868
    Conserved Domains (6) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25548
    Location:15171680
    DUF4670; Domain of unknown function (DUF4670)
  6. NM_001366321.1NP_001353250.1  afadin isoform 7

    Status: INFERRED

    Source sequence(s)
    AL009178, AL049698, AL731868
    Conserved Domains (6) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:385485
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:597925
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10011083
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25548
    Location:15101673
    DUF4670; Domain of unknown function (DUF4670)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    167826872..167972023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010879.1XP_016866368.1  afadin isoform X2

    UniProtKB/TrEMBL
    J3KN01
    Related
    ENSP00000252692.5, OTTHUMP00000017635, ENST00000351017.8, OTTHUMT00000043151
  2. XM_005266996.3XP_005267053.1  afadin isoform X6

    UniProtKB/Swiss-Prot
    P55196
    Related
    ENSP00000404595.2, OTTHUMP00000223316, ENST00000447894.6, OTTHUMT00000372077
    Conserved Domains (6) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25548
    Location:15171680
    DUF4670; Domain of unknown function (DUF4670)
  3. XM_024446446.1XP_024302214.1  afadin isoform X8

    Conserved Domains (6) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25548
    Location:15171678
    DUF4670; Domain of unknown function (DUF4670)
  4. XM_017010884.1XP_016866373.1  afadin isoform X10

  5. XM_017010886.1XP_016866375.1  afadin isoform X12

  6. XM_017010878.1XP_016866367.1  afadin isoform X1

  7. XM_006715491.2XP_006715554.1  afadin isoform X13

    Conserved Domains (5) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
  8. XM_017010882.1XP_016866371.1  afadin isoform X5

  9. XM_005266997.2XP_005267054.1  afadin isoform X7

    Conserved Domains (5) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612933
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10091091
    PDZ; PDZ domain (Also known as DHR or GLGF)
  10. XM_017010883.1XP_016866372.1  afadin isoform X9

    Conserved Domains (6) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:385485
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:597925
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10011083
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25548
    Location:15101673
    DUF4670; Domain of unknown function (DUF4670)
  11. XM_017010881.1XP_016866370.1  afadin isoform X4

  12. XM_017010885.1XP_016866374.1  afadin isoform X11

    Conserved Domains (5) summary
    cd01781
    Location:246345
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:383483
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:595916
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:9921074
    PDZ; PDZ domain (Also known as DHR or GLGF)
  13. XM_006715494.3XP_006715557.1  afadin isoform X15

    Conserved Domains (5) summary
    cd01781
    Location:246345
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:383483
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:595916
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:9921074
    PDZ; PDZ domain (Also known as DHR or GLGF)
  14. XM_017010880.1XP_016866369.1  afadin isoform X3

  15. XM_017010887.1XP_016866376.1  afadin isoform X14

RNA

  1. XR_001743427.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040001.1: Suppressed sequence

    Description
    NM_001040001.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NM_005936.2: Suppressed sequence

    Description
    NM_005936.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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