Format

Send to:

Choose Destination

Afdn afadin, adherens junction formation factor [ Mus musculus (house mouse) ]

Gene ID: 17356, updated on 2-Apr-2019

Summary

Official Symbol
Afdnprovided by MGI
Official Full Name
afadin, adherens junction formation factorprovided by MGI
Primary source
MGI:MGI:1314653
See related
Ensembl:ENSMUSG00000068036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AF6; Af-6; Gm314; Mllt4; Afadin; I-afadin; S-afadin; 5033403D15Rik
Expression
Ubiquitous expression in CNS E14 (RPKM 14.2), whole brain E14.5 (RPKM 13.1) and 28 other tissues See more
Orthologs

Genomic context

See Afdn in Genome Data Viewer
Location:
17; 17 A1
Exon count:
35
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (13760541..13905798)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (13897548..14042801)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700054A10 gene Neighboring gene sperm motility kinase 4A Neighboring gene predicted gene, 41530 Neighboring gene t-complex-associated testis expressed 2 Neighboring gene predicted gene 7168 Neighboring gene predicted gene, 33889

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
    Adherens junctions interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell junction organization, organism-specific biosystem (from REACTOME)
    Cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
    Cell-cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
LIM domain binding ISO
Inferred from Sequence Orthology
more info
 
Ras GTPase binding ISO
Inferred from Sequence Orthology
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adherens junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
brain morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex development IGI
Inferred from Genetic Interaction
more info
PubMed 
cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite arborization ISO
Inferred from Sequence Orthology
more info
 
establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
homeostasis of number of cells IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
neuroepithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mini excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
protein localization to cell junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
radial glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of oligodendrocyte progenitor proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
telencephalon development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
afadin
Names
myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
protein Af-6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010806.1NP_034936.1  afadin

    See identical proteins and their annotated locations for NP_034936.1

    Status: VALIDATED

    Source sequence(s)
    AF172447, BI991173, BQ929757, BU611478, CB181965, CF538789, CJ165098, CK637291, CN529812, CN537179, CN538841, CO042367, CO433521
    Consensus CDS
    CCDS49955.1
    UniProtKB/Swiss-Prot
    Q9QZQ1
    Related
    ENSMUSP00000118318.1, ENSMUST00000139666.7
    Conserved Domains (7) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam03064
    Location:15921678
    U79_P34; HSV U79 / HCMV P34
    pfam15346
    Location:15251668
    ARGLU; Arginine and glutamate-rich 1
    cl00155
    Location:20131
    UBQ; Ubiquitin-like proteins

RNA

  1. NR_151731.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155253, AC174800, CT030652

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    13760541..13905798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523752.2XP_006523815.1  afadin isoform X1

    Conserved Domains (7) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15331688
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15991698
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_006523763.2XP_006523826.1  afadin isoform X13

    Conserved Domains (7) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15331688
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15991698
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. XM_006523755.2XP_006523818.1  afadin isoform X4

    Conserved Domains (7) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam03064
    Location:16001697
    U79_P34; HSV U79 / HCMV P34
    pfam15346
    Location:15331687
    ARGLU; Arginine and glutamate-rich 1
  4. XM_006523759.2XP_006523822.1  afadin isoform X10

    Conserved Domains (7) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam03064
    Location:16001686
    U79_P34; HSV U79 / HCMV P34
    pfam15346
    Location:15331676
    ARGLU; Arginine and glutamate-rich 1
  5. XM_006523764.2XP_006523827.1  afadin isoform X15

    Conserved Domains (7) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam03064
    Location:16001686
    U79_P34; HSV U79 / HCMV P34
    pfam15346
    Location:15331676
    ARGLU; Arginine and glutamate-rich 1
  6. XM_006523757.2XP_006523820.1  afadin isoform X6

    Conserved Domains (7) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612933
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10091091
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15261681
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15921691
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  7. XM_006523766.2XP_006523829.1  afadin isoform X14

    Related
    ENSMUSP00000114485.1, ENSMUST00000137708.7
    Conserved Domains (7) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612933
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10091091
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15261681
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15921691
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  8. XM_006523760.2XP_006523823.1  afadin isoform X11

    Conserved Domains (7) summary
    cd01781
    Location:248347
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:385485
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:597925
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10011083
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15181673
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15841683
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  9. XM_006523754.2XP_006523817.1  afadin isoform X3

    Conserved Domains (7) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20132
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611939
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10151097
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15321687
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15981697
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  10. XM_017317275.1XP_017172764.1  afadin isoform X8

  11. XM_006523753.2XP_006523816.1  afadin isoform X2

    Conserved Domains (7) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611939
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10151097
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15321687
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15981697
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  12. XM_006523765.2XP_006523828.1  afadin isoform X16

    UniProtKB/TrEMBL
    E9Q9C3
    Related
    ENSMUSP00000119153.1, ENSMUST00000137784.7
    Conserved Domains (7) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611939
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10151097
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam03064
    Location:15991685
    U79_P34; HSV U79 / HCMV P34
    pfam15346
    Location:15321675
    ARGLU; Arginine and glutamate-rich 1
    cl00155
    Location:20131
    UBQ; Ubiquitin-like proteins
  13. XM_006523758.2XP_006523821.1  afadin isoform X7

    Conserved Domains (7) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15251680
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15911690
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  14. XM_006523756.2XP_006523819.1  afadin isoform X5

    Conserved Domains (7) summary
    cd01781
    Location:246345
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:416498
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:610938
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10141096
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15311686
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15971696
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  15. XM_017317276.1XP_017172765.1  afadin isoform X9

  16. XM_006523762.2XP_006523825.1  afadin isoform X12

    Conserved Domains (7) summary
    cd01781
    Location:246345
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:383483
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:595916
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:9921074
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15091664
    ARGLU; Arginine and glutamate-rich 1
    cl23720
    Location:15751674
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  17. XM_006523767.2XP_006523830.1  afadin isoform X17

    Conserved Domains (7) summary
    cd01781
    Location:246345
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd01782
    Location:20131
    AF6_RA_repeat1; Ubiquitin domain of AT-6, first repeat
    cd00060
    Location:383483
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:595916
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:9921074
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam03064
    Location:15761662
    U79_P34; HSV U79 / HCMV P34
    pfam15346
    Location:15091652
    ARGLU; Arginine and glutamate-rich 1

RNA

  1. XR_001782046.1 RNA Sequence

  2. XR_001782047.1 RNA Sequence

  3. XR_001782048.1 RNA Sequence

  4. XR_385293.2 RNA Sequence

Support Center