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Afdn afadin, adherens junction formation factor [ Mus musculus (house mouse) ]

Gene ID: 17356, updated on 18-Sep-2024

Summary

Official Symbol
Afdnprovided by MGI
Official Full Name
afadin, adherens junction formation factorprovided by MGI
Primary source
MGI:MGI:1314653
See related
Ensembl:ENSMUSG00000068036 AllianceGenome:MGI:1314653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AF6; Af-6; Gm314; Mllt4; Afadin; I-afadin; S-afadin; 5033403D15Rik
Summary
Enables cell adhesion molecule binding activity. Involved in cell-cell adhesion mediated by cadherin; establishment of protein localization to plasma membrane; and pore complex assembly. Acts upstream of or within several processes, including adherens junction maintenance; nervous system development; and regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including adherens junction; apical junction complex; and apical part of cell. Part of pore complex. Is expressed in eye; genitourinary system; and nervous system. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 14.2), whole brain E14.5 (RPKM 13.1) and 28 other tissues See more
Orthologs
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Genomic context

See Afdn in Genome Data Viewer
Location:
17 A1- A2; 17 8.95 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13980735..14126059)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (13760391..13905798)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41530 Neighboring gene STARR-seq mESC enhancer starr_41878 Neighboring gene predicted gene, 24867 Neighboring gene t-complex-associated testis expressed 2 Neighboring gene STARR-seq mESC enhancer starr_41882 Neighboring gene STARR-seq mESC enhancer starr_41883 Neighboring gene STARR-seq mESC enhancer starr_41885 Neighboring gene predicted gene 7168 Neighboring gene predicted gene, 33889

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables LIM domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adherens junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brain morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite arborization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuroepithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pore complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mini excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to cell junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within radial glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of oligodendrocyte progenitor proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within telencephalon development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of pore complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of pore complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
afadin
Names
myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
protein Af-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010806.1NP_034936.1  afadin

    See identical proteins and their annotated locations for NP_034936.1

    Status: VALIDATED

    Source sequence(s)
    AF172447, BI991173, BQ929757, BU611478, CB181965, CF538789, CJ165098, CK637291, CN529812, CN537179, CN538841, CO042367, CO433521
    Consensus CDS
    CCDS49955.1
    UniProtKB/Swiss-Prot
    Q9QZQ1
    UniProtKB/TrEMBL
    E9Q852
    Related
    ENSMUSP00000118318.2, ENSMUST00000139666.8
    Conserved Domains (7) summary
    cd01781
    Location:247346
    AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam03064
    Location:15921678
    U79_P34; HSV U79 / HCMV P34
    pfam15346
    Location:15251668
    ARGLU; Arginine and glutamate-rich 1
    cl00155
    Location:20131
    UBQ; Ubiquitin-like proteins

RNA

  1. NR_151731.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155253, AC174800, CT030652

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13980735..14126059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523752.4XP_006523815.1  afadin isoform X1

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15991698
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14651717
    DUF5401; Family of unknown function (DUF5401)
  2. XM_006523763.4XP_006523826.1  afadin isoform X16

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15991698
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14651717
    DUF5401; Family of unknown function (DUF5401)
  3. XM_006523755.4XP_006523818.1  afadin isoform X4

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    PTZ00121
    Location:15091694
    PTZ00121; MAEBL; Provisional
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:16031697
    ARGLU; Arginine and glutamate-rich 1
  4. XM_030249527.2XP_030105387.1  afadin isoform X17

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    PTZ00121
    Location:15091694
    PTZ00121; MAEBL; Provisional
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:16031697
    ARGLU; Arginine and glutamate-rich 1
  5. XM_006523759.4XP_006523822.1  afadin isoform X10

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam05672
    Location:16021686
    MAP7; MAP7 (E-MAP-115) family
    pfam17380
    Location:14851705
    DUF5401; Family of unknown function (DUF5401)
  6. XM_006523764.4XP_006523827.1  afadin isoform X19

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612940
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10161098
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam05672
    Location:16021686
    MAP7; MAP7 (E-MAP-115) family
    pfam17380
    Location:14851705
    DUF5401; Family of unknown function (DUF5401)
  7. XM_006523757.4XP_006523820.1  afadin isoform X6

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612933
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10091091
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15921691
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14581710
    DUF5401; Family of unknown function (DUF5401)
  8. XM_006523766.4XP_006523829.1  afadin isoform X18

    UniProtKB/TrEMBL
    E9Q852
    Related
    ENSMUSP00000114485.2, ENSMUST00000137708.8
    Conserved Domains (7) summary
    cd00060
    Location:418500
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:612933
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10091091
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15921691
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14581710
    DUF5401; Family of unknown function (DUF5401)
  9. XM_006523760.4XP_006523823.1  afadin isoform X11

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:385485
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:597925
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10011083
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15841683
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14501702
    DUF5401; Family of unknown function (DUF5401)
  10. XM_030249528.2XP_030105388.1  afadin isoform X21

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:385485
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:597925
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10011083
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam05672
    Location:15871671
    MAP7; MAP7 (E-MAP-115) family
    pfam17380
    Location:14701690
    DUF5401; Family of unknown function (DUF5401)
  11. XM_030249526.2XP_030105386.1  afadin isoform X14

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:385485
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:597918
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:248348
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:9941076
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15771676
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14431695
    DUF5401; Family of unknown function (DUF5401)
  12. XM_006523754.4XP_006523817.1  afadin isoform X3

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611939
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:247347
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10151097
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15981697
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14641716
    DUF5401; Family of unknown function (DUF5401)
  13. XM_017317275.3XP_017172764.1  afadin isoform X8

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:247347
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20132
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15911690
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14571709
    DUF5401; Family of unknown function (DUF5401)
  14. XM_006523753.4XP_006523816.1  afadin isoform X2

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611939
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:247347
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20131
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10151097
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15981697
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14641716
    DUF5401; Family of unknown function (DUF5401)
  15. XM_006523765.4XP_006523828.1  afadin isoform X20

    UniProtKB/TrEMBL
    E9Q852, E9Q9C3
    Related
    ENSMUSP00000119153.2, ENSMUST00000137784.8
    Conserved Domains (7) summary
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611939
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:247347
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20131
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10151097
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam05672
    Location:16011685
    MAP7; MAP7 (E-MAP-115) family
    pfam17380
    Location:14841704
    DUF5401; Family of unknown function (DUF5401)
  16. XM_006523758.4XP_006523821.1  afadin isoform X7

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:417499
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:611932
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:247347
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20131
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10081090
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15911690
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14571709
    DUF5401; Family of unknown function (DUF5401)
  17. XM_036160347.1XP_036016240.1  afadin isoform X12

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (6) summary
    cd00060
    Location:384484
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:596924
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:247347
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20131
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10001082
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15709
    Location:15071681
    DUF4670; Domain of unknown function (DUF4670)
  18. XM_006523756.4XP_006523819.1  afadin isoform X5

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:416498
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:610938
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:246346
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20131
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10141096
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15971696
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14631715
    DUF5401; Family of unknown function (DUF5401)
  19. XM_017317276.3XP_017172765.1  afadin isoform X9

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:416498
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:610931
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:246346
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20131
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:10071089
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15901689
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14561708
    DUF5401; Family of unknown function (DUF5401)
  20. XM_036160348.1XP_036016241.1  afadin isoform X13

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (6) summary
    cd00060
    Location:383483
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:595923
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:246346
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20131
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:9991081
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15709
    Location:15061680
    DUF4670; Domain of unknown function (DUF4670)
  21. XM_006523762.4XP_006523825.1  afadin isoform X15

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:383483
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:595916
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:246346
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20131
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:9921074
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam15346
    Location:15751674
    ARGLU; Arginine and glutamate-rich 1
    pfam17380
    Location:14411693
    DUF5401; Family of unknown function (DUF5401)
  22. XM_006523767.4XP_006523830.1  afadin isoform X22

    UniProtKB/TrEMBL
    E9Q852
    Conserved Domains (7) summary
    cd00060
    Location:383483
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd15471
    Location:595916
    Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
    cd01781
    Location:246346
    RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
    cd01782
    Location:20131
    RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
    pfam00595
    Location:9921074
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam05672
    Location:15781662
    MAP7; MAP7 (E-MAP-115) family
    pfam17380
    Location:14611681
    DUF5401; Family of unknown function (DUF5401)

RNA

  1. XR_385293.4 RNA Sequence

  2. XR_001782046.3 RNA Sequence

  3. XR_001782047.3 RNA Sequence

  4. XR_003952091.2 RNA Sequence