Conserved Protein Domain Family

cl00155: UBQ Superfamily (this model, PSSM-Id:320785 is obsolete)
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Ubiquitin-like proteins
Ubiquitin homologs; Includes ubiquitin and ubiquitin-like proteins. Ubiquitin-mediated proteolysis is part of the regulated turnover of proteins required for controlling cell cycle progression. Other family members are protein modifiers that perform a wide range of functions. Ubiquitination usually results in a covalent bond between the C-terminus of ubiquitin and the epsilon-amino group of a substrate lysine. The three-step mechanism requires an activating enzyme (E1) that forms a thiol ester with the C-terminal carboxy group, a conjugating enzyme (E2) that transiently carries the activated ubiquitin molecule as a thiol ester, and a ligase (E3) that transfers the activated ubiquitin from the E2 to the substrate lysine residue. In poly-ubiquitination, ubiquitin itself is the substrate.
Taxonomy: root
PubMed: 288 links
Protein: Related Protein
Related Structure
Accession: cl00155
PSSM Id: 320785
Name: UBQ
Created: 8-Feb-2008
Updated: 5-Dec-2016
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