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    PCBP1 poly(rC) binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 5093, updated on 7-Apr-2024

    Summary

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    Official Symbol
    PCBP1provided by HGNC
    Official Full Name
    poly(rC) binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:8647
    See related
    Ensembl:ENSG00000169564 MIM:601209; AllianceGenome:HGNC:8647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1
    Summary
    This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2p13.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (70087477..70089203)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (70099201..70100927)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70314609..70316335)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aspartic peptidase retroviral like 1 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 1834 Neighboring gene PCBP1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:70199285-70200162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:70202867-70203378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:70203379-70203889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:70211622-70212122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:70212123-70212623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:70220299-70220798 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:70224580-70224834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15983 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:70256223-70257094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15984 Neighboring gene Sharpr-MPRA regulatory region 12254 Neighboring gene RNA, 7SL, cytoplasmic 470, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11604 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70315031-70315675 Neighboring gene conserved acetylation island sequence C15 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11605 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11606 Neighboring gene uncharacterized LOC124906022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15990 Neighboring gene mitochondrial ribosomal protein L36 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PCBP1 is associated with rheumatoid arthritis by affecting RNA products of genes involved in immune response in Th1 cells. Cao X, et al. Sci Rep, 2022 May 19. PMID 35589811, Free PMC Article
    2. Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR. Li Z, et al. Curr Gene Ther, 2022. PMID 35549870
    3. Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion. Cousineau SE, et al. Viruses, 2022 Jan 29. PMID 35215884, Free PMC Article
    4. Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones. Philpott CC, et al. Biochim Biophys Acta Mol Cell Res, 2020 Nov. PMID 32835748, Free PMC Article
    5. RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity. Ansa-Addo EA, et al. Sci Adv, 2020 May. PMID 32523987, Free PMC Article

    See all (324) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness.
      Title: PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness.
    2. Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.
      Title: Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program.
    3. PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.
      Title: PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.
    4. Overexpression of splicing factor poly(rC)-binding protein 1 elicits cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells.
      Title: Overexpression of splicing factor poly(rC)-binding protein 1 elicits cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells.
    5. Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR.
      Title: Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR.
    6. PCBP1 is associated with rheumatoid arthritis by affecting RNA products of genes involved in immune response in Th1 cells.
      Title: PCBP1 is associated with rheumatoid arthritis by affecting RNA products of genes involved in immune response in Th1 cells.
    7. PolyC-RNA-binding protein 1 (PCBP1) enhances tropomyosin 3 (TPM3) mRNA stability to promote the progression of esophageal squamous cell carcinoma.
      Title: PolyC-RNA-binding protein 1 (PCBP1) enhances tropomyosin 3 (TPM3) mRNA stability to promote the progression of esophageal squamous cell carcinoma.
    8. Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer.
      Title: Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer.
    9. RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity.
      Title: RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity.
    10. Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion.
      Title: Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion.
    Submit: New GeneRIF Correction See all GeneRIFs (86)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify poly(rC) binding protein 1 (PCBP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify poly(rC) binding protein 1 (PCBP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify poly(rC) binding protein 1 (PCBP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify poly(rC) binding protein 1 (PCBP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev Deletion of the C-terminal 148 amino acids in hnRNP E1 protein abrogates its ability to inhibit Rev expression PubMed
    rev Human hnRNP E1/E2 interacts with the ESS3a element of the bipartite ESS in tat/rev exon 3 of HIV-1, and modulation of hnRNP E1 expression alters HIV-1 p24 capsid and Rev protein expression PubMed
    rev HIV-1 Rev interacts with the heterogeneous nuclear ribonucleoproteins (hnRNP) E1 PubMed
    Tat tat Poly(rC) binding protein 1 (PCBP1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    capsid gag The interaction of HIV-1 CA with human cellular poly(rC) binding protein 1 (PCBP1, hnRNP E1: heterogenous nuclear ribonucleoprotein E1) is identified by yeast two-hybrid screen PubMed
    gag Human hnRNP E1/E2 interacts with the ESS3a element of the bipartite ESS in tat/rev exon 3 of HIV-1, and modulation of hnRNP E1 expression alters HIV-1 p24 capsid and Rev protein expression PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadherin binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific single stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in viral RNA genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(rC)-binding protein 1
    Names
    alpha-CP1
    epididymis secretory protein Li 85
    heterogeneous nuclear ribonucleoprotein E1
    heterogenous nuclear ribonucleoprotein E1
    heterogenous nuclear ribonucleoprotein X
    nucleic acid-binding protein SUB2.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029956.1 RefSeqGene

      Range
      5025..6751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006196.4 → NP_006187.2  poly(rC)-binding protein 1

      See identical proteins and their annotated locations for NP_006187.2

      Status: REVIEWED

      Source sequence(s)
      BC039742, BM794597, Z29505
      Consensus CDS
      CCDS1898.1
      UniProtKB/Swiss-Prot
      Q13157, Q14975, Q15365
      UniProtKB/TrEMBL
      Q53SS8
      Related
      ENSP00000305556.5, ENST00000303577.7
      Conserved Domains (3) summary
      cd22515
      Location:13 → 82
      KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22518
      Location:92 → 169
      KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
      cd22521
      Location:276 → 351
      KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      70087477..70089203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      70099201..70100927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15365.2 GenPept UniProtKB/Swiss-Prot:Q15365

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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