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Pcbp1 poly(rC) binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 23983, updated on 8-Feb-2024

Summary

Official Symbol
Pcbp1provided by MGI
Official Full Name
poly(rC) binding protein 1provided by MGI
Primary source
MGI:MGI:1345635
See related
Ensembl:ENSMUSG00000051695 AllianceGenome:MGI:1345635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WBP17; [a]CP-1; hnRNP E1; hnRNP-E1; alphaCP-1
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific single stranded DNA binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in embryo. Orthologous to human PCBP1 (poly(rC) binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Pcbp1 in Genome Data Viewer
Location:
6 37.72 cM; 6 D1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86501462..86503171, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86524480..86526189, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310040G24 gene Neighboring gene STARR-seq mESC enhancer starr_16530 Neighboring gene predicted gene, 52866 Neighboring gene STARR-seq mESC enhancer starr_16532 Neighboring gene RIKEN cDNA 1600020E01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86476390-86476577 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86543221-86543408 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86557648-86557801 Neighboring gene aspartic peptidase, retroviral-like 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific single stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation activator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
poly(rC)-binding protein 1
Names
alpha-CP1
heterogeneous nuclear ribonucleoprotein E1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011865.4NP_035995.1  poly(rC)-binding protein 1

    See identical proteins and their annotated locations for NP_035995.1

    Status: VALIDATED

    Source sequence(s)
    AC153374
    Consensus CDS
    CCDS20314.1
    UniProtKB/Swiss-Prot
    P60335
    Related
    ENSMUSP00000054863.6, ENSMUST00000053015.7
    Conserved Domains (3) summary
    cd22515
    Location:1382
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:276351
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    86501462..86503171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)