Format

Send to:

Choose Destination

PCBP1 poly(rC) binding protein 1 [ Homo sapiens (human) ]

Gene ID: 5093, updated on 9-Dec-2018

Summary

Official Symbol
PCBP1provided by HGNC
Official Full Name
poly(rC) binding protein 1provided by HGNC
Primary source
HGNC:HGNC:8647
See related
Ensembl:ENSG00000169564 MIM:601209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1
Summary
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See PCBP1 in Genome Data Viewer
Location:
2p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (70087453..70089203)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70313972..70316335)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene PCBP1 antisense RNA 1 Neighboring gene aspartic peptidase retroviral like 1 Neighboring gene RNA, 7SL, cytoplasmic 470, pseudogene Neighboring gene conserved acetylation island sequence C15 enhancer Neighboring gene mitochondrial ribosomal protein L36 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1816

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify poly(rC) binding protein 1 (PCBP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify poly(rC) binding protein 1 (PCBP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify poly(rC) binding protein 1 (PCBP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify poly(rC) binding protein 1 (PCBP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev Deletion of the C-terminal 148 amino acids in hnRNP E1 protein abrogates its ability to inhibit Rev expression PubMed
rev Human hnRNP E1/E2 interacts with the ESS3a element of the bipartite ESS in tat/rev exon 3 of HIV-1, and modulation of hnRNP E1 expression alters HIV-1 p24 capsid and Rev protein expression PubMed
rev HIV-1 Rev interacts with the heterogeneous nuclear ribonucleoproteins (hnRNP) E1 PubMed
Tat tat Poly(rC) binding protein 1 (PCBP1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
capsid gag The interaction of HIV-1 CA with human cellular poly(rC) binding protein 1 (PCBP1, hnRNP E1: heterogenous nuclear ribonucleoprotein E1) is identified by yeast two-hybrid screen PubMed
gag Human hnRNP E1/E2 interacts with the ESS3a element of the bipartite ESS in tat/rev exon 3 of HIV-1, and modulation of hnRNP E1 expression alters HIV-1 p24 capsid and Rev protein expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Ferroptosis, organism-specific biosystem (from KEGG)
    Ferroptosis, organism-specific biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
  • Ferroptosis, conserved biosystem (from KEGG)
    Ferroptosis, conserved biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific single stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA metabolic process TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
viral RNA genome replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
poly(rC)-binding protein 1
Names
alpha-CP1
epididymis secretory protein Li 85
heterogeneous nuclear ribonucleoprotein E1
heterogenous nuclear ribonucleoprotein E1
heterogenous nuclear ribonucleoprotein X
nucleic acid-binding protein SUB2.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029956.1 RefSeqGene

    Range
    5001..6751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006196.3NP_006187.2  poly(rC)-binding protein 1

    See identical proteins and their annotated locations for NP_006187.2

    Status: REVIEWED

    Source sequence(s)
    BC039742, BM794597, Z29505
    Consensus CDS
    CCDS1898.1
    UniProtKB/Swiss-Prot
    Q15365
    UniProtKB/TrEMBL
    Q53SS8
    Related
    ENSP00000305556.5, ENST00000303577.6
    Conserved Domains (2) summary
    cd02396
    Location:99163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:281345
    KH_1; KH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    70087453..70089203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center