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rev p19 [ Human immunodeficiency virus 1 ]

Gene ID: 155908, updated on 5-Aug-2014
Gene symbol
rev
Gene description
p19
Locus tag
HIV1gp6
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Human immunodeficiency virus 1 (gb-acronym: HIV-1)
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
Sequence:
NC_001802.1 (5516..8199)

NC_001802.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol Neighboring gene Pr55(Gag) Neighboring gene p23 Neighboring gene p15 Neighboring gene p14 Neighboring gene p16 Neighboring gene gp160; envelope glycoprotein Neighboring gene minus-strand-encoded antisense protein of unknown function; region is highly conserved and likely analogous to the HTLV-1 encoded, HBZ, a nuclear basic region leucine zipper (b-ZIP) protein Neighboring gene p27

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
ATP-binding cassette sub-family F member 1 isoform b ABCF1 interacts with PubMed
apoptotic chromatin condensation inducer in the nucleus isoform 1 ACIN1 interacts with PubMed
actin, cytoplasmic 1 ACTB associates with PubMed
ACTB associates with PubMed
ACTB associates with PubMed
double-stranded RNA-specific adenosine deaminase isoform a ADAR interacts with PubMed
ADAR regulated by PubMed
arf-GAP domain and FG repeat-containing protein 1 isoform 2 AGFG1 binds PubMed
AGFG1 binds PubMed
AGFG1 binds PubMed
AGFG1 requires PubMed
arf-GAP domain and FG repeat-containing protein 2 AGFG2 binds PubMed
AGFG2 binds PubMed
S-adenosylmethionine decarboxylase proenzyme isoform 1 AMD1 requires PubMed
acidic leucine-rich nuclear phosphoprotein 32 family member A ANP32A interacts with PubMed
ANP32A interacts with PubMed
acidic leucine-rich nuclear phosphoprotein 32 family member B ANP32B interacts with PubMed
ANP32B interacts with PubMed
acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1 ANP32E interacts with PubMed
DNA-(apurinic or apyrimidinic site) lyase APEX1 interacts with PubMed
serine-protein kinase ATM ATM stimulated by PubMed
sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a ATP2A2 interacts with PubMed
UPF0568 protein C14orf166 C14orf166 interacts with PubMed
complement component 1 Q subcomponent-binding protein, mitochondrial precursor C1QBP binds PubMed
C1QBP inhibits PubMed
C1QBP binds PubMed
C1QBP binds PubMed
ashwin isoform 1 C2orf49 interacts with PubMed
calreticulin precursor CALR interacts with PubMed
caprin-1 isoform 1 CAPRIN1 interacts with PubMed
cell division cycle 5-like protein CDC5L interacts with PubMed
cyclin-dependent kinase 1 isoform 1 CDK1 phosphorylated by PubMed
coiled-coil-helix-coiled-coil-helix domain-containing protein 1 CHCHD1 interacts with PubMed
cleavage and polyadenylation specificity factor subunit 2 CPSF2 interacts with PubMed
cleavage and polyadenylation specificity factor subunit 6 CPSF6 interacts with PubMed
cleavage and polyadenylation specificity factor subunit 7 isoform 1 CPSF7 interacts with PubMed
casein kinase II subunit alpha isoform a CSNK2A1 interacts with PubMed
CSNK2A1 modulated by PubMed
CSNK2A1 activates PubMed
CSNK2A1 phosphorylated by PubMed
CSNK2A1 binds PubMed
CSNK2A1 phosphorylated by PubMed
casein kinase II subunit alpha' CSNK2A2 interacts with PubMed
CSNK2A2 modulated by PubMed
CSNK2A2 activates PubMed
CSNK2A2 phosphorylated by PubMed
CSNK2A2 binds PubMed
CSNK2A2 phosphorylated by PubMed
casein kinase II subunit beta isoform 1 CSNK2B interacts with PubMed
CSNK2B binds PubMed
CSNK2B modulated by PubMed
CSNK2B activates PubMed
CSNK2B phosphorylated by PubMed
CSNK2B phosphorylated by PubMed
cleavage stimulation factor subunit 2 CSTF2 interacts with PubMed
cleavage stimulation factor subunit 3 isoform 1 CSTF3 interacts with PubMed
cullin-4A isoform 2 CUL4A interacts with PubMed
cullin-4B isoform 1 CUL4B interacts with PubMed
C-X-C chemokine receptor type 4 isoform b CXCR4 inhibits PubMed
DAZ-associated protein 1 isoform b DAZAP1 interacts with PubMed
DNA damage-binding protein 1 DDB1 interacts with PubMed
ATP-dependent RNA helicase DDX1 DDX1 co-localizes with PubMed
DDX1 interacts with PubMed
DDX1 interacts with PubMed
DDX1 interacts with PubMed
DDX1 interacts with PubMed
DDX1 relocalized by PubMed
DDX1 relocalized by PubMed
DDX1 interacts with PubMed
probable ATP-dependent RNA helicase DDX17 isoform 1 DDX17 interacts with PubMed
DDX17 interacts with PubMed
nucleolar RNA helicase 2 isoform 1 DDX21 enhanced by PubMed
DDX21 interacts with PubMed
ATP-dependent RNA helicase DDX24 DDX24 interacts with PubMed
DDX24 interacts with PubMed
ATP-dependent RNA helicase DDX3X isoform 1 DDX3X regulated by PubMed
DDX3X enhanced by PubMed
DDX3X interacts with PubMed
DDX3X exported by PubMed
DDX3X interacts with PubMed
probable ATP-dependent RNA helicase DDX47 isoform 1 DDX47 interacts with PubMed
probable ATP-dependent RNA helicase DDX5 DDX5 enhanced by PubMed
DDX5 interacts with PubMed
DDX5 interacts with PubMed
probable ATP-dependent RNA helicase DDX56 isoform 1 DDX56 interacts with PubMed
ATP-dependent RNA helicase DHX36 isoform 1 DHX36 interacts with PubMed
ATP-dependent RNA helicase A DHX9 interacts with PubMed
DHX9 interacts with PubMed
endoribonuclease Dicer isoform 1 DICER1 inhibits PubMed
dnaJ homolog subfamily A member 1 DNAJA1 inhibited by PubMed
dnaJ homolog subfamily B member 6 isoform b DNAJB6 inhibited by PubMed
cytoplasmic dynein 1 heavy chain 1 DYNC1H1 interacts with PubMed
elongation factor 1-alpha 1 EEF1A1 interacts with PubMed
eukaryotic translation initiation factor 2 subunit 2 EIF2S2 interacts with PubMed
eukaryotic translation initiation factor 2 subunit 3 EIF2S3 interacts with PubMed
eukaryotic translation initiation factor 3 subunit I EIF3I interacts with PubMed
eukaryotic translation initiation factor 3 subunit M EIF3M interacts with PubMed
eukaryotic translation initiation factor 5A-1 isoform B EIF5A binds PubMed
EIF5A interacts with PubMed
EIF5A interacts with PubMed
EIF5A binds PubMed
EIF5A interacts with PubMed
EIF5A binds PubMed
ribosomal RNA small subunit methyltransferase NEP1 EMG1 interacts with PubMed
epsin-2 isoform a EPN2 interacts with PubMed
TFIIH basal transcription factor complex helicase XPD subunit isoform 1 ERCC2 interacts with PubMed
ERCC2 interacts with PubMed
TFIIH basal transcription factor complex helicase XPB subunit ERCC3 interacts with PubMed
ERCC3 interacts with PubMed
enhancer of rudimentary homolog ERH interacts with PubMed
RNA-binding protein EWS isoform 2 EWSR1 interacts with PubMed
exosome complex component CSL4 EXOSC1 interacts with PubMed
exosome complex component RRP46 EXOSC5 interacts with PubMed
exosome complex component RRP42 EXOSC7 interacts with PubMed
WASH complex subunit FAM21A isoform 1 FAM21A inhibited by PubMed
FAM21A co-localizes with PubMed
FAM21A interacts with PubMed
WASH complex subunit FAM21C isoform 1 FAM21C interacts with PubMed
FAM21C inhibited by PubMed
FAM21C co-localizes with PubMed
protein FAM98B FAM98B interacts with PubMed
ubiquitin-like protein fubi and ribosomal protein S30 precursor FAU interacts with PubMed
RNA-binding protein FUS isoform 1 FUS interacts with PubMed
glyceraldehyde-3-phosphate dehydrogenase isoform 1 GAPDH interacts with PubMed
guanine nucleotide-binding protein subunit beta-2-like 1 GNB2L1 interacts with PubMed
G patch domain-containing protein 4 isoform 1 GPATCH4 interacts with PubMed
GPN-loop GTPase 1 isoform a GPN1 interacts with PubMed
histone H2A.J H2AFJ interacts with PubMed
histone H3.3 H3F3B interacts with PubMed
HCLS1-associated protein X-1 isoform a HAX1 co-localizes with PubMed
HAX1 binds PubMed
histone H2B type 1-B HIST1H2BB interacts with PubMed
histone H2B type 1-C/E/F/G/I HIST1H2BC interacts with PubMed
histone H2B type 1-D HIST1H2BD interacts with PubMed
histone H2B type 1-H HIST1H2BH interacts with PubMed
histone H2B type 1-M HIST1H2BM interacts with PubMed
histone H2B type 1-N HIST1H2BN interacts with PubMed
histone H4 HIST1H4A interacts with PubMed
histone H2B type 2-E HIST2H2BE interacts with PubMed
histone H2B type 2-F isoform a HIST2H2BF interacts with PubMed
histone H2B type 3-B HIST3H2BB interacts with PubMed
histone H3.1t HIST3H3 co-localizes with PubMed
hexokinase-2 HK2 interacts with PubMed
major histocompatibility complex, class I, B precursor HLA-B interacts with PubMed
HLA class I histocompatibility antigen, Cw-1 alpha chain precursor HLA-C interacts with PubMed
heterogeneous nuclear ribonucleoprotein A1 isoform a HNRNPA1 interacts with PubMed
HNRNPA1 interacts with PubMed
HNRNPA1 modulated by PubMed
HNRNPA1 interacts with PubMed
HNRNPA1 stimulates PubMed
heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2 HNRNPA2B1 interacts with PubMed
heterogeneous nuclear ribonucleoprotein A3 HNRNPA3 interacts with PubMed
heterogeneous nuclear ribonucleoprotein A/B isoform b HNRNPAB interacts with PubMed
heterogeneous nuclear ribonucleoproteins C1/C2 isoform b HNRNPC interacts with PubMed
heterogeneous nuclear ribonucleoprotein D0 isoform d HNRNPD interacts with PubMed
heterogeneous nuclear ribonucleoprotein D-like isoform a HNRNPDL interacts with PubMed
heterogeneous nuclear ribonucleoprotein F HNRNPF interacts with PubMed
heterogeneous nuclear ribonucleoprotein H HNRNPH1 interacts with PubMed
heterogeneous nuclear ribonucleoprotein H2 HNRNPH2 interacts with PubMed
heterogeneous nuclear ribonucleoprotein H3 isoform a HNRNPH3 interacts with PubMed
heterogeneous nuclear ribonucleoprotein K isoform a HNRNPK interacts with PubMed
HNRNPK interacts with PubMed
heterogeneous nuclear ribonucleoprotein M isoform a HNRNPM interacts with PubMed
heterogeneous nuclear ribonucleoprotein R isoform 2 HNRNPR interacts with PubMed
HNRNPR binds PubMed
heterogeneous nuclear ribonucleoprotein U isoform b HNRNPU interacts with PubMed
HNRNPU interacts with PubMed
endoplasmin precursor HSP90B1 interacts with PubMed
E3 ubiquitin-protein ligase HUWE1 HUWE1 interacts with PubMed
insulin-like growth factor 2 mRNA-binding protein 1 isoform 1 IGF2BP1 interacts with PubMed
insulin-like growth factor 2 mRNA-binding protein 2 isoform a IGF2BP2 inhibited by PubMed
protein Red IK interacts with PubMed
interleukin enhancer-binding factor 2 isoform 1 ILF2 interacts with PubMed
interleukin enhancer-binding factor 3 isoform a ILF3 interacts with PubMed
ILF3 inhibited by PubMed
ILF3 regulated by PubMed
ILF3 regulated by PubMed
ILF3 interacts with PubMed
importin-5 IPO5 binds PubMed
IPO5 inhibited by PubMed
importin-7 IPO7 interacts with PubMed
inosine triphosphate pyrophosphatase isoform a ITPA inhibits PubMed
KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform 1 KHDRBS1 requires PubMed
KHDRBS1 requires PubMed
KHDRBS1 inhibited by PubMed
KHDRBS1 modulated by PubMed
KHDRBS1 inhibited by PubMed
KHDRBS1 synergizes with PubMed
KHDRBS1 binds PubMed
KH domain-containing, RNA-binding, signal transduction-associated protein 2 KHDRBS2 enhanced by PubMed
KH domain-containing, RNA-binding, signal transduction-associated protein 3 KHDRBS3 enhanced by PubMed
kinesin-like protein KIF22 isoform 1 KIF22 binds PubMed
importin subunit alpha-5 KPNA1 interacts with PubMed
importin subunit alpha-1 KPNA2 interacts with PubMed
importin subunit alpha-3 KPNA4 interacts with PubMed
importin subunit alpha-7 KPNA6 interacts with PubMed
importin subunit beta-1 isoform 1 KPNB1 interacts with PubMed
KPNB1 binds PubMed
KPNB1 inhibited by PubMed
KPNB1 binds PubMed
KRR1 small subunit processome component homolog KRR1 binds PubMed
galectin-3 isoform 1 LGALS3 inhibits PubMed
DNA ligase 3 isoform beta precursor LIG3 interacts with PubMed
lamin isoform C LMNA binds PubMed
mitogen-activated protein kinase 1 MAPK1 phosphorylated by PubMed
mitogen-activated protein kinase 3 isoform 1 MAPK3 phosphorylated by PubMed
matrin-3 isoform a MATR3 regulated by PubMed
MATR3 interacts with PubMed
MATR3 interacts with PubMed
DNA replication licensing factor MCM3 isoform 1 MCM3 co-localizes with PubMed
myoD family inhibitor domain-containing protein isoform p40 MDFIC downregulated by PubMed
MDFIC inhibited by PubMed
MDFIC interacts with PubMed
microfibrillar-associated protein 1 MFAP1 interacts with PubMed
MIT domain-containing protein 1 MITD1 interacts with PubMed
DNA-3-methyladenine glycosylase isoform a MPG interacts with PubMed
39S ribosomal protein L11, mitochondrial isoform a MRPL11 interacts with PubMed
39S ribosomal protein L42, mitochondrial precursor MRPL42 interacts with PubMed
28S ribosomal protein S28, mitochondrial MRPS28 interacts with PubMed
28S ribosomal protein S9, mitochondrial MRPS9 interacts with PubMed
magnesium transporter MRS2 homolog, mitochondrial isoform b precursor MRS2 interacts with PubMed
myb-binding protein 1A isoform 2 MYBBP1A interacts with PubMed
nucleosome assembly protein 1-like 1 NAP1L1 interacts with PubMed
NAP1L1 interacts with PubMed
nucleosome assembly protein 1-like 4 NAP1L4 interacts with PubMed
asparagine--tRNA ligase, cytoplasmic NARS interacts with PubMed
N-acetyltransferase 10 isoform a NAT10 interacts with PubMed
NF-kappa-B inhibitor alpha NFKBIA inhibited by PubMed
nipped-B-like protein isoform B NIPBL interacts with PubMed
nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 interacts with PubMed
non-POU domain-containing octamer-binding protein isoform 1 NONO interacts with PubMed
nucleolar protein 58 NOP58 interacts with PubMed
nucleolar protein 9 isoform 1 NOP9 interacts with PubMed
nucleophosmin isoform 1 NPM1 interacts with PubMed
NPM1 co-localizes with PubMed
NPM1 interacts with PubMed
NPM1 binds PubMed
NPM1 associates with PubMed
NPM1 binds PubMed
NPM1 stimulated by PubMed
nardilysin isoform a NRD1 interacts with PubMed
nuclear pore complex protein Nup153 isoform 2 NUP153 inhibited by PubMed
NUP153 interacts with PubMed
nuclear pore complex protein Nup214 NUP214 interacts with PubMed
NUP214 interacts with PubMed
NUP214 inhibited by PubMed
NUP214 recruits PubMed
NUP214 inhibited by PubMed
nuclear pore glycoprotein p62 NUP62 interacts with PubMed
nuclear pore complex protein Nup98-Nup96 isoform 3 NUP98 interacts with PubMed
NUP98 interacts with PubMed
NUP98 recruits PubMed
NUP98 inhibited by PubMed
nucleoporin-like protein 2 NUPL2 interacts with PubMed
NUPL2 interacts with PubMed
protein disulfide-isomerase precursor P4HB interacts with PubMed
polyadenylate-binding protein 1 PABPC1 interacts with PubMed
PABPC1 interacts with PubMed
PAX3- and PAX7-binding protein 1 isoform 2 PAXBP1 interacts with PubMed
poly(rC)-binding protein 1 PCBP1 inhibits PubMed
PCBP1 modulated by PubMed
PCBP1 interacts with PubMed
poly(rC)-binding protein 2 isoform a PCBP2 interacts with PubMed
protein RRP5 homolog PDCD11 interacts with PubMed
6-phosphofructokinase, liver type isoform b PFKL interacts with PubMed
6-phosphofructokinase type C isoform 1 PFKP interacts with PubMed
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor PLOD1 interacts with PubMed
pleiotropic regulator 1 isoform 1 PLRG1 interacts with PubMed
bifunctional polynucleotide phosphatase/kinase PNKP interacts with PubMed
serum paraoxonase/arylesterase 2 isoform 1 PON2 interacts with PubMed
suppressor of SWI4 1 homolog PPAN interacts with PubMed
PPAN-P2RY11 protein isoform 1 PPAN-P2RY11 interacts with PubMed
peptidyl-prolyl cis-trans isomerase B precursor PPIB interacts with PubMed
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1 PPP2R2A interacts with PubMed
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform a PPP2R2D interacts with PubMed
serine/threonine-protein phosphatase 6 catalytic subunit isoform b PPP6C interacts with PubMed
protein kinase C alpha type PRKCA phosphorylated by PubMed
DNA-dependent protein kinase catalytic subunit isoform 1 PRKDC interacts with PubMed
interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 1 PRKRA binds PubMed
protein arginine N-methyltransferase 6 PRMT6 methylated by PubMed
PRMT6 methylated by PubMed
pre-mRNA-processing factor 19 PRPF19 interacts with PubMed
U4/U6 small nuclear ribonucleoprotein Prp31 PRPF31 interacts with PubMed
serine/threonine-protein kinase PRP4 homolog PRPF4B interacts with PubMed
pre-mRNA-processing factor 6 PRPF6 interacts with PubMed
pre-mRNA-processing-splicing factor 8 PRPF8 interacts with PubMed
PC4 and SFRS1-interacting protein isoform 1 PSIP1 complexes with PubMed
PSIP1 interacts with PubMed
paraspeckle component 1 PSPC1 interacts with PubMed
polypyrimidine tract-binding protein 1 isoform a PTBP1 interacts with PubMed
prostaglandin E synthase 3 isoform a PTGES3 interacts with PubMed
prothymosin alpha isoform 2 PTMA binds PubMed
transcriptional activator protein Pur-alpha PURA interacts with PubMed
PURA co-localizes with PubMed
transcriptional activator protein Pur-beta PURB interacts with PubMed
GTP-binding nuclear protein Ran RAN interacts with PubMed
RAN enhanced by PubMed
RAN binds PubMed
RAN binds PubMed
ran-specific GTPase-activating protein isoform 2 RANBP1 competes with PubMed
E3 SUMO-protein ligase RanBP2 RANBP2 regulated by PubMed
ran GTPase-activating protein 1 RANGAP1 interacts with PubMed
putative RNA-binding protein 15 isoform 1 RBM15 interacts with PubMed
RNA-binding protein 39 isoform b RBM39 interacts with PubMed
RNA-binding protein 42 RBM42 interacts with PubMed
ATP-dependent DNA helicase Q1 RECQL interacts with PubMed
60S ribosomal protein L17 isoform a RPL17 interacts with PubMed
60S ribosomal protein L23 RPL23 interacts with PubMed
60S ribosomal protein L27 RPL27 interacts with PubMed
60S ribosomal protein L3 isoform a RPL3 interacts with PubMed
60S ribosomal protein L32 RPL32 interacts with PubMed
60S ribosomal protein L35a RPL35A interacts with PubMed
60S ribosomal protein L5 RPL5 interacts with PubMed
60S ribosomal protein L6 RPL6 interacts with PubMed
40S ribosomal protein S17 RPS17 interacts with PubMed
40S ribosomal protein S2 RPS2 interacts with PubMed
40S ribosomal protein S23 RPS23 interacts with PubMed
40S ribosomal protein S25 RPS25 interacts with PubMed
ubiquitin-40S ribosomal protein S27a precursor RPS27A interacts with PubMed
40S ribosomal protein S3a isoform 1 RPS3A interacts with PubMed
40S ribosomal protein S4, X isoform X isoform RPS4X interacts with PubMed
40S ribosomal protein S5 RPS5 interacts with PubMed
40S ribosomal protein S6 RPS6 interacts with PubMed
40S ribosomal protein SA RPSA interacts with PubMed
tRNA-splicing ligase RtcB homolog RTCB interacts with PubMed
ruvB-like 1 RUVBL1 interacts with PubMed
scaffold attachment factor B1 isoform 3 SAFB interacts with PubMed
protein SET isoform 2 SET interacts with PubMed
splicing factor 3A subunit 1 isoform 1 SF3A1 interacts with PubMed
splicing factor 3A subunit 2 SF3A2 interacts with PubMed
splicing factor 3A subunit 3 SF3A3 interacts with PubMed
splicing factor, proline- and glutamine-rich SFPQ regulated by PubMed
SFPQ interacts with PubMed
superkiller viralicidic activity 2-like 2 SKIV2L2 interacts with PubMed
WD40 repeat-containing protein SMU1 SMU1 interacts with PubMed
U5 small nuclear ribonucleoprotein 200 kDa helicase SNRNP200 interacts with PubMed
U5 small nuclear ribonucleoprotein 40 kDa protein SNRNP40 interacts with PubMed
U1 small nuclear ribonucleoprotein 70 kDa SNRNP70 interacts with PubMed
U2 small nuclear ribonucleoprotein A' SNRPA1 inhibits PubMed
U1 small nuclear ribonucleoprotein C SNRPC interacts with PubMed
small nuclear ribonucleoprotein E SNRPE interacts with PubMed
small nuclear ribonucleoprotein F SNRPF interacts with PubMed
small nuclear ribonucleoprotein G SNRPG interacts with PubMed
spermatogenesis-associated serine-rich protein 2 SPATS2 interacts with PubMed
spectrin alpha chain, non-erythrocytic 1 isoform 2 SPTAN1 interacts with PubMed
spectrin beta chain, non-erythrocytic 1 isoform 1 SPTBN1 interacts with PubMed
S1 RNA-binding domain-containing protein 1 SRBD1 interacts with PubMed
signal recognition particle 54 kDa protein isoform 1 SRP54 interacts with PubMed
signal recognition particle 9 kDa protein isoform 2 SRP9 interacts with PubMed
serine/arginine-rich splicing factor 1 isoform 1 SRSF1 requires PubMed
SRSF1 inhibits PubMed
SRSF1 inhibited by PubMed
SRSF1 interacts with PubMed
serine/arginine-rich splicing factor 2 SRSF2 inhibited by PubMed
SRSF2 co-localizes with PubMed
serine/arginine-rich splicing factor 5 SRSF5 requires PubMed
serine/arginine-rich splicing factor 9 SRSF9 interacts with PubMed
lupus La protein SSB interacts with PubMed
SSB interacts with PubMed
single-stranded DNA-binding protein, mitochondrial precursor SSBP1 interacts with PubMed
stress-induced-phosphoprotein 1 isoform b STIP1 interacts with PubMed
activated RNA polymerase II transcriptional coactivator p15 SUB1 interacts with PubMed
FACT complex subunit SPT16 SUPT16H interacts with PubMed
heterogeneous nuclear ribonucleoprotein Q isoform 1 SYNCRIP cooperates with PubMed
SYNCRIP interacts with PubMed
SYNCRIP binds PubMed
RISC-loading complex subunit TARBP2 isoform b TARBP2 binds PubMed
protein-glutamine gamma-glutamyltransferase 2 isoform a TGM2 inhibited by PubMed
trimethylguanosine synthase TGS1 associates with PubMed
THO complex subunit 6 homolog isoform 1 THOC6 interacts with PubMed
transmembrane emp24 domain-containing protein 10 precursor TMED10 interacts with PubMed
transmembrane emp24 domain-containing protein 4 precursor TMED4 interacts with PubMed
transmembrane emp24 domain-containing protein 9 precursor TMED9 interacts with PubMed
transportin-1 isoform 1 TNPO1 interacts with PubMed
TNPO1 inhibited by PubMed
TNPO1 binds PubMed
transportin-3 isoform 1 TNPO3 disrupts PubMed
TNPO3 binds PubMed
target of EGR1 protein 1 TOE1 interacts with PubMed
cellular tumor antigen p53 isoform a TP53 activates PubMed
pachytene checkpoint protein 2 homolog isoform 1 TRIP13 interacts with PubMed
TRMT1-like protein isoform 1 TRMT1L interacts with PubMed
tubulin alpha-1A chain isoform 1 TUBA1A interacts with PubMed
TUBA1A depolymerizes PubMed
tubulin alpha-1B chain TUBA1B interacts with PubMed
TUBA1B depolymerizes PubMed
tubulin alpha-1C chain TUBA1C interacts with PubMed
TUBA1C depolymerizes PubMed
tubulin alpha-3C/D chain TUBA3C depolymerizes PubMed
tubulin alpha-4A chain isoform 1 TUBA4A interacts with PubMed
TUBA4A depolymerizes PubMed
tubulin alpha-8 chain isoform 1 TUBA8 interacts with PubMed
TUBA8 depolymerizes PubMed
tubulin beta chain isoform b TUBB interacts with PubMed
tubulin beta-1 chain TUBB1 depolymerizes PubMed
tubulin beta-2A chain TUBB2A interacts with PubMed
TUBB2A depolymerizes PubMed
tubulin beta-2B chain TUBB2B interacts with PubMed
tubulin beta-3 chain isoform 1 TUBB3 interacts with PubMed
TUBB3 depolymerizes PubMed
tubulin beta-4A chain isoform 3 TUBB4A interacts with PubMed
TUBB4A depolymerizes PubMed
tubulin beta-4B chain TUBB4B interacts with PubMed
TUBB4B depolymerizes PubMed
tubulin beta-6 chain TUBB6 depolymerizes PubMed
tubulin beta-8 chain TUBB8 depolymerizes PubMed
splicing factor U2AF 35 kDa subunit isoform a U2AF1 interacts with PubMed
polyubiquitin-B precursor UBB ubiquitinated by PubMed
polyubiquitin-C UBC ubiquitinated by PubMed
ubiquitin D UBD ubiquitinated by PubMed
E3 ubiquitin-protein ligase UBR4 UBR4 interacts with PubMed
U4/U6.U5 tri-snRNP-associated protein 2 isoform 1 USP39 interacts with PubMed
WD repeat-containing protein 3 WDR3 interacts with PubMed
WD repeat-containing protein 36 WDR36 interacts with PubMed
exportin-1 XPO1 interacts with PubMed
XPO1 regulated by PubMed
XPO1 regulated by PubMed
XPO1 regulated by PubMed
XPO1 co-localizes with PubMed
XPO1 exported by PubMed
XPO1 enhanced by PubMed
XPO1 interacts with PubMed
XPO1 binds PubMed
XPO1 binds PubMed
XPO1 recruits PubMed
XPO1 interacts with PubMed
XPO1 interacts with PubMed
XPO1 binds PubMed
XPO1 binds PubMed
XPO1 interacts with PubMed
XPO1 interacts with PubMed
XPO1 inhibited by PubMed
XPO1 modulated by PubMed

Go to the HIV-1, Human Protein Interaction Database

  • 2-LTR circle formation, organism-specific biosystem (from REACTOME)
    2-LTR circle formation, organism-specific biosystemThe formation of 2-LTR circles requires the action of the cellular non-homologous DNA end-joining pathway. Specifically the cellular Ku, XRCC4 and ligase IV proteins are needed. Evidence for this i...
  • APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystem (from REACTOME)
    APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystemRepresentatives of the apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3) family provide innate resistance to exogeneous and endogenous retroviruses (see Cullen 2006 for a recent ...
  • Assembly Of The HIV Virion, organism-specific biosystem (from REACTOME)
    Assembly Of The HIV Virion, organism-specific biosystemVirion assembly packages all the components required for infectivity. These steps include two copies of the positive sense genomic viral RNA, cellular tRNALys, the viral envelope (Env) protein, the G...
  • Autointegration results in viral DNA circles, organism-specific biosystem (from REACTOME)
    Autointegration results in viral DNA circles, organism-specific biosystemIn this pathway, the viral integration machinery uses a site within the viral DNA as an integration target. This results in a covalent rearrangment of the viral DNA. The resulting DNA forms are no...
  • Binding and entry of HIV virion, organism-specific biosystem (from REACTOME)
    Binding and entry of HIV virion, organism-specific biosystemHIV enters cells by fusion at the cell surface, that results in a productive infection. The envelope (Env) protein of HIV mediates entry. Env is composed of a surface subunit, gp120, and a transmemb...
  • Budding and maturation of HIV virion, organism-specific biosystem (from REACTOME)
    Budding and maturation of HIV virion, organism-specific biosystemWith the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathwa...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Early Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Early Phase of HIV Life Cycle, organism-specific biosystemIn the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • HIV Life Cycle, organism-specific biosystem (from REACTOME)
    HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
  • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
    Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
  • Integration of provirus, organism-specific biosystem (from REACTOME)
    Integration of provirus, organism-specific biosystemFor retroviral DNA to direct production of progeny virions it must become covalently integrated into the host cell chromosome (reviewed in Coffin et al. 1997; Hansen et al. 1998). Analyses of mutants...
  • Integration of viral DNA into host genomic DNA, organism-specific biosystem (from REACTOME)
    Integration of viral DNA into host genomic DNA, organism-specific biosystemFollowing nuclear entry, the viral preintegration complex (PIC) must select a site for integration in a host cell chromosome, and then carry out the chemical steps of the reaction. At the chromosomal...
  • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
    Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
  • Interactions of Vpr with host cellular proteins, organism-specific biosystem (from REACTOME)
    Interactions of Vpr with host cellular proteins, organism-specific biosystemVpr has been implicated in multiple processes during HIV-1 replication, including nuclear import of the pre-integration complex (PIC)(Heinzinger et al., 1994), apoptosis (Stewart et al., 1997) and in...
  • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
  • Minus-strand DNA synthesis, organism-specific biosystem (from REACTOME)
    Minus-strand DNA synthesis, organism-specific biosystemIn the first part of reverse transcription, minus-strand synthesis, a DNA strand complementary to the HIV genomic RNA is synthesized, using the viral RNA as a template and a host cell lysine tRNA mol...
  • Plus-strand DNA synthesis, organism-specific biosystem (from REACTOME)
    Plus-strand DNA synthesis, organism-specific biosystemTwo specific polypurine tracts (PPT sequences) in the viral RNA, one within the pol gene (central or cPPT) and one immediately preceding the U3 sequence (3' PPT), are spared from degradation during m...
  • Rev-mediated nuclear export of HIV RNA, organism-specific biosystem (from REACTOME)
    Rev-mediated nuclear export of HIV RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
  • Reverse Transcription of HIV RNA, organism-specific biosystem (from REACTOME)
    Reverse Transcription of HIV RNA, organism-specific biosystemThe RNA genome of HIV-1, like that of other retroviruses, is reverse-transcribed (Baltimore 1970; Temin and Mizutani 1970) into double-stranded DNA, which is then integrated into a host cell chromoso...
  • Uncoating of the HIV Virion, organism-specific biosystem (from REACTOME)
    Uncoating of the HIV Virion, organism-specific biosystemHIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, t...
  • Vpr-mediated nuclear import of PICs, organism-specific biosystem (from REACTOME)
    Vpr-mediated nuclear import of PICs, organism-specific biosystemVpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins.
Products Interactant Other Gene Complex Source Pubs Description

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001802.1 

    Range
    5516..8199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057854.1 Rev [Human immunodeficiency virus 1]

    See proteins identical to NP_057854.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P04618
    UniProtKB/TrEMBL
    Q77YF8
    Conserved Domains (1) summary
    pfam00424
    Location:192
    Blast Score: 212
    REV; REV protein (anti-repression trans-activator protein)