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    rev p19 [ Human immunodeficiency virus 1 ]

    Gene ID: 155908, updated on 11-May-2013
    Gene symbol
    rev
    Gene description
    p19
    Locus tag
    HIV1gp6
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Human immunodeficiency virus 1 (gb-acronym: HIV-1)
    Lineage
    Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
    Sequence :
    NC_001802.1 (5516..8199)

    NC_001802.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol Neighboring gene Pr55(Gag) Neighboring gene p23 Neighboring gene p15 Neighboring gene p14 Neighboring gene p16 Neighboring gene gp160; envelope glycoprotein Neighboring gene p27

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3. Kula A, et al. Virology, 2013 Jan 20. PMID 23158102.
    2. The HIV-1 Rev protein enhances encapsidation of unspliced and spliced, RRE-containing lentiviral vector RNA. Grewe B, et al. PLoS One, 2012. PMID 23133650.
    3. Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses. Shida H. Front Microbiol, 2012. PMID 22783232.
    4. Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains. Hoffmann D, et al. PLoS One, 2012. PMID 22675540.
    5. Viral diversity and diversification of major non-structural genes vif, vpr, vpu, tat exon 1 and rev exon 1 during primary HIV-1 subtype C infection. Rossenkhan R, et al. PLoS One, 2012. PMID 22590503.

    See all (191) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. HIV-1 Rev protein enhances encapsidation of unspliced and spliced, RRE-containing lentiviral vector RNA
      Title: The HIV-1 Rev protein enhances encapsidation of unspliced and spliced, RRE-containing lentiviral vector RNA.
    2. PSF and MATR3 are cellular host factors that bind viral RNA and promote Rev activity.
      Title: HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3.
    3. Rev oligomerization on the Rev Response Element, thereby recruiting at least two protein activation domains, is required for nuclear export of unspliced and incompletely spliced viral RNA.
      Title: Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.
    4. Viral diversity and diversification of major non-structural genes vif, vpr, vpu, tat exon 1 and rev exon 1 during primary HIV-1 subtype C infection.
      Title: Viral diversity and diversification of major non-structural genes vif, vpr, vpu, tat exon 1 and rev exon 1 during primary HIV-1 subtype C infection.
    5. DDX1 was shown to be an RNA-activated ATPase, wherein Rev-bound RNA was equally effective at stimulating ATPase activity as protein-free RNA.
      Title: DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication.
    6. we hypothesize that CRM1 was subject to strong selection event in primate lineage ~80 million years ago that altered sequence of HEAT repeat 9A. Resulting CRM1 sequence is better able to support HIV-1 Rev's function as mediator of viral RNA nuclear export
      Title: Evolution of a species-specific determinant within human CRM1 that regulates the post-transcriptional phases of HIV-1 replication.
    7. Rev dimerization and oligomerization interfaces to a resolution of 2.5A.
      Title: A long-awaited structure is rev-ealed.
    8. HIV-1 Rev protein activates HCV gene expression
      Title: Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by directly targeting the HCV 5'-untranslated region.
    9. Rev protein of Human Immunodeficiency Virus type 1 (HIV-1) inhibits nuclear import and mediates nuclear export of the HIV-1 integrase (IN) protein
      Title: Nucleocytoplasmic shuttling of HIV-1 integrase is controlled by the viral Rev protein.
    10. The position of the charges in aminoglycoside antibiotics and the flexibility of their structure, rather than the number of charges, determines whether an aminoglycoside antibiotic will be able to bind with high affinity to TAR RNA.
      Title: Effect of salt concentration on the conformation of TAR RNA and its association with aminoglycoside antibiotics.
    Submit: New GeneRIF Correction See all (45)
    Protein Gene Interaction Pubs
    ATP-binding cassette sub-family F member 1 isoform b ABCF1 interacts with PubMed
    apoptotic chromatin condensation inducer in the nucleus isoform 1 ACIN1 interacts with PubMed
    actin, cytoplasmic 1 ACTB associates with PubMed
    ACTB associates with PubMed
    ACTB associates with PubMed
    double-stranded RNA-specific adenosine deaminase isoform a ADAR interacts with PubMed
    ADAR regulated by PubMed
    arf-GAP domain and FG repeat-containing protein 1 isoform 2 AGFG1 binds PubMed
    AGFG1 binds PubMed
    AGFG1 binds PubMed
    AGFG1 requires PubMed
    arf-GAP domain and FG repeat-containing protein 2 AGFG2 binds PubMed
    AGFG2 binds PubMed
    S-adenosylmethionine decarboxylase proenzyme isoform 1 precursor AMD1 requires PubMed
    acidic leucine-rich nuclear phosphoprotein 32 family member A ANP32A interacts with PubMed
    ANP32A interacts with PubMed
    acidic leucine-rich nuclear phosphoprotein 32 family member B ANP32B interacts with PubMed
    ANP32B interacts with PubMed
    acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1 ANP32E interacts with PubMed
    DNA-(apurinic or apyrimidinic site) lyase APEX1 interacts with PubMed
    serine-protein kinase ATM ATM stimulated by PubMed
    sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a ATP2A2 interacts with PubMed
    UPF0568 protein C14orf166 C14orf166 interacts with PubMed
    complement component 1 Q subcomponent-binding protein, mitochondrial precursor C1QBP inhibits PubMed
    C1QBP binds PubMed
    C1QBP binds PubMed
    C1QBP binds PubMed
    tRNA-splicing ligase RtcB homolog C22orf28 interacts with PubMed
    ashwin C2orf49 interacts with PubMed
    calreticulin precursor CALR interacts with PubMed
    caprin-1 isoform 1 CAPRIN1 interacts with PubMed
    cell division cycle 5-like protein CDC5L interacts with PubMed
    cyclin-dependent kinase 1 isoform 1 CDK1 phosphorylated by PubMed
    coiled-coil-helix-coiled-coil-helix domain-containing protein 1 CHCHD1 interacts with PubMed
    cleavage and polyadenylation specificity factor subunit 2 CPSF2 interacts with PubMed
    cleavage and polyadenylation specificity factor subunit 6 CPSF6 interacts with PubMed
    cleavage and polyadenylation specificity factor subunit 7 isoform 1 CPSF7 interacts with PubMed
    casein kinase II subunit alpha isoform a CSNK2A1 interacts with PubMed
    CSNK2A1 modulated by PubMed
    CSNK2A1 activates PubMed
    CSNK2A1 phosphorylated by PubMed
    CSNK2A1 binds PubMed
    CSNK2A1 phosphorylated by PubMed
    casein kinase II subunit alpha' CSNK2A2 interacts with PubMed
    CSNK2A2 modulated by PubMed
    CSNK2A2 activates PubMed
    CSNK2A2 phosphorylated by PubMed
    CSNK2A2 binds PubMed
    CSNK2A2 phosphorylated by PubMed
    casein kinase II subunit beta CSNK2B interacts with PubMed
    CSNK2B binds PubMed
    CSNK2B modulated by PubMed
    CSNK2B activates PubMed
    CSNK2B phosphorylated by PubMed
    CSNK2B phosphorylated by PubMed
    cleavage stimulation factor subunit 2 CSTF2 interacts with PubMed
    cleavage stimulation factor subunit 3 isoform 1 CSTF3 interacts with PubMed
    cullin-4A isoform 2 CUL4A interacts with PubMed
    cullin-4B isoform 1 CUL4B interacts with PubMed
    C-X-C chemokine receptor type 4 isoform b CXCR4 inhibits PubMed
    DAZ-associated protein 1 isoform b DAZAP1 interacts with PubMed
    DNA damage-binding protein 1 DDB1 interacts with PubMed
    ATP-dependent RNA helicase DDX1 DDX1 interacts with PubMed
    DDX1 interacts with PubMed
    DDX1 interacts with PubMed
    DDX1 relocalized by PubMed
    DDX1 relocalized by PubMed
    DDX1 interacts with PubMed
    DDX1 interacts with PubMed
    probable ATP-dependent RNA helicase DDX17 isoform 1 DDX17 interacts with PubMed
    ATP-dependent RNA helicase DDX24 DDX24 interacts with PubMed
    DDX24 interacts with PubMed
    ATP-dependent RNA helicase DDX3X isoform 1 DDX3X interacts with PubMed
    DDX3X exported by PubMed
    probable ATP-dependent RNA helicase DDX47 isoform 1 DDX47 interacts with PubMed
    probable ATP-dependent RNA helicase DDX5 DDX5 interacts with PubMed
    probable ATP-dependent RNA helicase DHX36 isoform 1 DHX36 interacts with PubMed
    ATP-dependent RNA helicase A DHX9 interacts with PubMed
    DHX9 interacts with PubMed
    cytoplasmic dynein 1 heavy chain 1 DYNC1H1 interacts with PubMed
    elongation factor 1-alpha 1 EEF1A1 interacts with PubMed
    eukaryotic translation initiation factor 2 subunit 2 EIF2S2 interacts with PubMed
    eukaryotic translation initiation factor 2 subunit 3 EIF2S3 interacts with PubMed
    eukaryotic translation initiation factor 3 subunit I EIF3I interacts with PubMed
    eukaryotic translation initiation factor 3 subunit M EIF3M interacts with PubMed
    eukaryotic translation initiation factor 5A-1 isoform B EIF5A binds PubMed
    EIF5A interacts with PubMed
    EIF5A interacts with PubMed
    EIF5A binds PubMed
    EIF5A interacts with PubMed
    EIF5A binds PubMed
    ribosomal RNA small subunit methyltransferase NEP1 EMG1 interacts with PubMed
    epsin-2 isoform a EPN2 interacts with PubMed
    TFIIH basal transcription factor complex helicase XPD subunit isoform 1 ERCC2 interacts with PubMed
    ERCC2 interacts with PubMed
    TFIIH basal transcription factor complex helicase XPB subunit ERCC3 interacts with PubMed
    ERCC3 interacts with PubMed
    enhancer of rudimentary homolog ERH interacts with PubMed
    RNA-binding protein EWS isoform 2 EWSR1 interacts with PubMed
    exosome complex component CSL4 EXOSC1 interacts with PubMed
    exosome complex component RRP46 EXOSC5 interacts with PubMed
    exosome complex component RRP42 EXOSC7 interacts with PubMed
    WASH complex subunit FAM21A FAM21A inhibited by PubMed
    FAM21A co-localizes with PubMed
    FAM21A interacts with PubMed
    WASH complex subunit FAM21B FAM21B inhibited by PubMed
    FAM21B co-localizes with PubMed
    FAM21B interacts with PubMed
    WASH complex subunit FAM21C isoform 1 FAM21C interacts with PubMed
    FAM21C inhibited by PubMed
    FAM21C co-localizes with PubMed
    protein FAM98B isoform 1 FAM98B interacts with PubMed
    ubiquitin-like protein fubi and ribosomal protein S30 precursor FAU interacts with PubMed
    RNA-binding protein FUS isoform 1 FUS interacts with PubMed
    glyceraldehyde-3-phosphate dehydrogenase isoform 1 GAPDH interacts with PubMed
    guanine nucleotide-binding protein subunit beta-2-like 1 GNB2L1 interacts with PubMed
    G patch domain-containing protein 4 isoform 1 GPATCH4 interacts with PubMed
    GPN-loop GTPase 1 isoform a GPN1 interacts with PubMed
    histone H2A.J H2AFJ interacts with PubMed
    histone H3.3 H3F3B interacts with PubMed
    HCLS1-associated protein X-1 isoform a HAX1 co-localizes with PubMed
    HAX1 binds PubMed
    histone H2B type 1-B HIST1H2BB interacts with PubMed
    histone H2B type 1-C/E/F/G/I HIST1H2BC interacts with PubMed
    histone H2B type 1-D HIST1H2BD interacts with PubMed
    histone H2B type 1-H HIST1H2BH interacts with PubMed
    histone H2B type 1-M HIST1H2BM interacts with PubMed
    histone H2B type 1-N HIST1H2BN interacts with PubMed
    histone H4 HIST1H4A interacts with PubMed
    histone H2B type 2-E HIST2H2BE interacts with PubMed
    histone H2B type 2-F isoform a HIST2H2BF interacts with PubMed
    histone H2B type 3-B HIST3H2BB interacts with PubMed
    hexokinase-2 HK2 interacts with PubMed
    major histocompatibility complex, class I, B precursor HLA-B interacts with PubMed
    HLA class I histocompatibility antigen, Cw-1 alpha chain precursor HLA-C interacts with PubMed
    heterogeneous nuclear ribonucleoprotein A1 isoform a HNRNPA1 interacts with PubMed
    HNRNPA1 interacts with PubMed
    HNRNPA1 modulated by PubMed
    HNRNPA1 interacts with PubMed
    HNRNPA1 stimulates PubMed
    heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2 HNRNPA2B1 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein A3 HNRNPA3 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein A/B isoform b HNRNPAB interacts with PubMed
    heterogeneous nuclear ribonucleoproteins C1/C2 isoform b HNRNPC interacts with PubMed
    heterogeneous nuclear ribonucleoprotein D0 isoform d HNRNPD interacts with PubMed
    heterogeneous nuclear ribonucleoprotein F HNRNPF interacts with PubMed
    heterogeneous nuclear ribonucleoprotein H HNRNPH1 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein H2 HNRNPH2 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein H3 isoform a HNRNPH3 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein K isoform a HNRNPK interacts with PubMed
    HNRNPK interacts with PubMed
    heterogeneous nuclear ribonucleoprotein M isoform a HNRNPM interacts with PubMed
    heterogeneous nuclear ribonucleoprotein R isoform 2 HNRNPR interacts with PubMed
    HNRNPR binds PubMed
    heterogeneous nuclear ribonucleoprotein U isoform b HNRNPU interacts with PubMed
    HNRNPU interacts with PubMed
    heterogeneous nuclear ribonucleoprotein D-like isoform a HNRPDL interacts with PubMed
    endoplasmin precursor HSP90B1 interacts with PubMed
    E3 ubiquitin-protein ligase HUWE1 HUWE1 interacts with PubMed
    insulin-like growth factor 2 mRNA-binding protein 1 isoform 1 IGF2BP1 interacts with PubMed
    insulin-like growth factor 2 mRNA-binding protein 2 isoform a IGF2BP2 inhibited by PubMed
    protein Red IK interacts with PubMed
    interleukin enhancer-binding factor 2 isoform 1 ILF2 interacts with PubMed
    interleukin enhancer-binding factor 3 isoform a ILF3 interacts with PubMed
    ILF3 inhibited by PubMed
    ILF3 regulated by PubMed
    ILF3 regulated by PubMed
    ILF3 interacts with PubMed
    importin-5 IPO5 binds PubMed
    IPO5 inhibited by PubMed
    importin-7 IPO7 interacts with PubMed
    inosine triphosphate pyrophosphatase isoform a ITPA inhibits PubMed
    KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform 1 KHDRBS1 requires PubMed
    KHDRBS1 requires PubMed
    KHDRBS1 inhibited by PubMed
    KHDRBS1 modulated by PubMed
    KHDRBS1 inhibited by PubMed
    KHDRBS1 synergizes with PubMed
    KHDRBS1 binds PubMed
    KH domain-containing, RNA-binding, signal transduction-associated protein 2 KHDRBS2 enhanced by PubMed
    KH domain-containing, RNA-binding, signal transduction-associated protein 3 KHDRBS3 enhanced by PubMed
    kinesin-like protein KIF22 isoform 1 KIF22 binds PubMed
    importin subunit alpha-1 KPNA1 interacts with PubMed
    importin subunit alpha-2 KPNA2 interacts with PubMed
    importin subunit alpha-4 KPNA4 interacts with PubMed
    importin subunit alpha-7 KPNA6 interacts with PubMed
    importin subunit beta-1 isoform 1 KPNB1 interacts with PubMed
    KPNB1 binds PubMed
    KPNB1 binds PubMed
    KPNB1 inhibited by PubMed
    KRR1 small subunit processome component homolog KRR1 binds PubMed
    galectin-3 isoform 1 LGALS3 inhibits PubMed
    DNA ligase 3 isoform beta precursor LIG3 interacts with PubMed
    lamin isoform C LMNA binds PubMed
    mitogen-activated protein kinase 1 MAPK1 phosphorylated by PubMed
    mitogen-activated protein kinase 3 isoform 1 MAPK3 phosphorylated by PubMed
    matrin-3 isoform a MATR3 interacts with PubMed
    MATR3 interacts with PubMed
    myoD family inhibitor domain-containing protein isoform p40 MDFIC downregulated by PubMed
    MDFIC inhibited by PubMed
    MDFIC interacts with PubMed
    microfibrillar-associated protein 1 MFAP1 interacts with PubMed
    MIT domain-containing protein 1 MITD1 interacts with PubMed
    DNA-3-methyladenine glycosylase isoform a MPG interacts with PubMed
    39S ribosomal protein L11, mitochondrial isoform a MRPL11 interacts with PubMed
    39S ribosomal protein L42, mitochondrial precursor MRPL42 interacts with PubMed
    28S ribosomal protein S28, mitochondrial MRPS28 interacts with PubMed
    28S ribosomal protein S9, mitochondrial MRPS9 interacts with PubMed
    magnesium transporter MRS2 homolog, mitochondrial precursor MRS2 interacts with PubMed
    myb-binding protein 1A isoform 2 MYBBP1A interacts with PubMed
    nucleosome assembly protein 1-like 1 NAP1L1 interacts with PubMed
    NAP1L1 interacts with PubMed
    nucleosome assembly protein 1-like 4 NAP1L4 interacts with PubMed
    asparagine--tRNA ligase, cytoplasmic NARS interacts with PubMed
    N-acetyltransferase 10 isoform a NAT10 interacts with PubMed
    NF-kappa-B inhibitor alpha NFKBIA inhibited by PubMed
    nipped-B-like protein isoform B NIPBL interacts with PubMed
    nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 interacts with PubMed
    non-POU domain-containing octamer-binding protein isoform 1 NONO interacts with PubMed
    nucleolar protein 58 NOP58 interacts with PubMed
    nucleolar protein 9 NOP9 interacts with PubMed
    nucleophosmin isoform 1 NPM1 interacts with PubMed
    NPM1 co-localizes with PubMed
    NPM1 associates with PubMed
    NPM1 binds PubMed
    NPM1 stimulated by PubMed
    NPM1 interacts with PubMed
    NPM1 binds PubMed
    nardilysin isoform a precursor NRD1 interacts with PubMed
    nuclear pore complex protein Nup153 isoform 2 NUP153 inhibited by PubMed
    NUP153 interacts with PubMed
    nuclear pore complex protein Nup214 NUP214 interacts with PubMed
    NUP214 interacts with PubMed
    NUP214 inhibited by PubMed
    NUP214 recruits PubMed
    NUP214 inhibited by PubMed
    nuclear pore glycoprotein p62 NUP62 interacts with PubMed
    nuclear pore complex protein Nup98-Nup96 isoform 3 NUP98 interacts with PubMed
    NUP98 interacts with PubMed
    NUP98 recruits PubMed
    NUP98 inhibited by PubMed
    nucleoporin-like protein 2 NUPL2 interacts with PubMed
    NUPL2 interacts with PubMed
    protein disulfide-isomerase precursor P4HB interacts with PubMed
    polyadenylate-binding protein 1 PABPC1 interacts with PubMed
    PABPC1 interacts with PubMed
    PAX3- and PAX7-binding protein 1 isoform 2 PAXBP1 interacts with PubMed
    poly(rC)-binding protein 1 PCBP1 inhibits PubMed
    PCBP1 modulated by PubMed
    PCBP1 interacts with PubMed
    poly(rC)-binding protein 2 isoform a PCBP2 interacts with PubMed
    protein RRP5 homolog PDCD11 interacts with PubMed
    6-phosphofructokinase, liver type PFKL interacts with PubMed
    6-phosphofructokinase type C isoform 1 PFKP interacts with PubMed
    procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor PLOD1 interacts with PubMed
    pleiotropic regulator 1 isoform 1 PLRG1 interacts with PubMed
    bifunctional polynucleotide phosphatase/kinase PNKP interacts with PubMed
    serum paraoxonase/arylesterase 2 isoform 1 PON2 interacts with PubMed
    suppressor of SWI4 1 homolog PPAN interacts with PubMed
    PPAN-P2RY11 protein isoform 1 PPAN-P2RY11 interacts with PubMed
    peptidyl-prolyl cis-trans isomerase B precursor PPIB interacts with PubMed
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1 PPP2R2A interacts with PubMed
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform PPP2R2D interacts with PubMed
    serine/threonine-protein phosphatase 6 catalytic subunit isoform b PPP6C interacts with PubMed
    protein kinase C alpha type PRKCA phosphorylated by PubMed
    DNA-dependent protein kinase catalytic subunit isoform 1 PRKDC interacts with PubMed
    protein arginine N-methyltransferase 6 PRMT6 methylated by PubMed
    pre-mRNA-processing factor 19 PRPF19 interacts with PubMed
    U4/U6 small nuclear ribonucleoprotein Prp31 PRPF31 interacts with PubMed
    serine/threonine-protein kinase PRP4 homolog PRPF4B interacts with PubMed
    pre-mRNA-processing factor 6 PRPF6 interacts with PubMed
    pre-mRNA-processing-splicing factor 8 PRPF8 interacts with PubMed
    PC4 and SFRS1-interacting protein isoform 1 PSIP1 complexes with PubMed
    PSIP1 interacts with PubMed
    paraspeckle component 1 PSPC1 interacts with PubMed
    polypyrimidine tract-binding protein 1 isoform a PTBP1 interacts with PubMed
    prostaglandin E synthase 3 PTGES3 interacts with PubMed
    prothymosin alpha isoform 2 PTMA binds PubMed
    transcriptional activator protein Pur-alpha PURA interacts with PubMed
    PURA co-localizes with PubMed
    transcriptional activator protein Pur-beta PURB interacts with PubMed
    GTP-binding nuclear protein Ran RAN interacts with PubMed
    RAN enhanced by PubMed
    RAN binds PubMed
    RAN binds PubMed
    ran-specific GTPase-activating protein RANBP1 competes with PubMed
    E3 SUMO-protein ligase RanBP2 RANBP2 regulated by PubMed
    ran GTPase-activating protein 1 RANGAP1 interacts with PubMed
    putative RNA-binding protein 15 isoform 1 RBM15 interacts with PubMed
    RNA-binding protein 39 isoform b RBM39 interacts with PubMed
    RNA-binding protein 42 RBM42 interacts with PubMed
    ATP-dependent DNA helicase Q1 RECQL interacts with PubMed
    60S ribosomal protein L17 isoform a RPL17 interacts with PubMed
    60S ribosomal protein L23 RPL23 interacts with PubMed
    60S ribosomal protein L27 RPL27 interacts with PubMed
    60S ribosomal protein L3 isoform a RPL3 interacts with PubMed
    60S ribosomal protein L32 RPL32 interacts with PubMed
    60S ribosomal protein L35a RPL35A interacts with PubMed
    60S ribosomal protein L5 RPL5 interacts with PubMed
    60S ribosomal protein L6 RPL6 interacts with PubMed
    40S ribosomal protein S17 RPS17 interacts with PubMed
    40S ribosomal protein S2 RPS2 interacts with PubMed
    40S ribosomal protein S23 RPS23 interacts with PubMed
    40S ribosomal protein S25 RPS25 interacts with PubMed
    ubiquitin-40S ribosomal protein S27a precursor RPS27A interacts with PubMed
    40S ribosomal protein S3a isoform 1 RPS3A interacts with PubMed
    40S ribosomal protein S4, X isoform X isoform RPS4X interacts with PubMed
    40S ribosomal protein S5 RPS5 interacts with PubMed
    40S ribosomal protein S6 RPS6 interacts with PubMed
    40S ribosomal protein SA RPSA interacts with PubMed
    ruvB-like 1 RUVBL1 interacts with PubMed
    scaffold attachment factor B1 isoform 3 SAFB interacts with PubMed
    protein SET isoform 2 SET interacts with PubMed
    splicing factor 3A subunit 1 isoform 1 SF3A1 interacts with PubMed
    splicing factor 3A subunit 2 SF3A2 interacts with PubMed
    splicing factor 3A subunit 3 SF3A3 interacts with PubMed
    splicing factor, proline- and glutamine-rich SFPQ interacts with PubMed
    superkiller viralicidic activity 2-like 2 SKIV2L2 interacts with PubMed
    WD40 repeat-containing protein SMU1 SMU1 interacts with PubMed
    U5 small nuclear ribonucleoprotein 200 kDa helicase SNRNP200 interacts with PubMed
    U5 small nuclear ribonucleoprotein 40 kDa protein SNRNP40 interacts with PubMed
    U1 small nuclear ribonucleoprotein 70 kDa SNRNP70 interacts with PubMed
    U2 small nuclear ribonucleoprotein A' SNRPA1 inhibits PubMed
    U1 small nuclear ribonucleoprotein C SNRPC interacts with PubMed
    small nuclear ribonucleoprotein E SNRPE interacts with PubMed
    small nuclear ribonucleoprotein F SNRPF interacts with PubMed
    small nuclear ribonucleoprotein G SNRPG interacts with PubMed
    spermatogenesis-associated serine-rich protein 2 SPATS2 interacts with PubMed
    spectrin alpha chain, non-erythrocytic 1 isoform 2 SPTAN1 interacts with PubMed
    spectrin beta chain, non-erythrocytic 1 isoform 1 SPTBN1 interacts with PubMed
    S1 RNA-binding domain-containing protein 1 SRBD1 interacts with PubMed
    signal recognition particle 54 kDa protein isoform 1 SRP54 interacts with PubMed
    signal recognition particle 9 kDa protein isoform 2 SRP9 interacts with PubMed
    serine/arginine-rich splicing factor 1 isoform 1 SRSF1 requires PubMed
    SRSF1 inhibits PubMed
    SRSF1 inhibited by PubMed
    SRSF1 interacts with PubMed
    serine/arginine-rich splicing factor 2 SRSF2 inhibited by PubMed
    SRSF2 co-localizes with PubMed
    serine/arginine-rich splicing factor 5 SRSF5 requires PubMed
    serine/arginine-rich splicing factor 9 SRSF9 interacts with PubMed
    lupus La protein SSB interacts with PubMed
    SSB interacts with PubMed
    single-stranded DNA-binding protein, mitochondrial precursor SSBP1 interacts with PubMed
    stress-induced-phosphoprotein 1 STIP1 interacts with PubMed
    activated RNA polymerase II transcriptional coactivator p15 SUB1 interacts with PubMed
    FACT complex subunit SPT16 SUPT16H interacts with PubMed
    heterogeneous nuclear ribonucleoprotein Q isoform 1 SYNCRIP interacts with PubMed
    SYNCRIP binds PubMed
    protein-glutamine gamma-glutamyltransferase 2 isoform a TGM2 inhibited by PubMed
    trimethylguanosine synthase TGS1 associates with PubMed
    THO complex subunit 6 homolog isoform 1 THOC6 interacts with PubMed
    transmembrane emp24 domain-containing protein 10 precursor TMED10 interacts with PubMed
    transmembrane emp24 domain-containing protein 4 precursor TMED4 interacts with PubMed
    transmembrane emp24 domain-containing protein 9 precursor TMED9 interacts with PubMed
    transportin-1 isoform 1 TNPO1 interacts with PubMed
    TNPO1 inhibited by PubMed
    TNPO1 binds PubMed
    transportin-3 isoform 1 TNPO3 binds PubMed
    TNPO3 disrupts PubMed
    target of EGR1 protein 1 TOE1 interacts with PubMed
    cellular tumor antigen p53 isoform a TP53 activates PubMed
    pachytene checkpoint protein 2 homolog isoform 1 TRIP13 interacts with PubMed
    TRMT1-like protein isoform 1 TRMT1L interacts with PubMed
    tubulin alpha-1A chain isoform 1 TUBA1A interacts with PubMed
    TUBA1A depolymerizes PubMed
    tubulin alpha-1B chain TUBA1B interacts with PubMed
    TUBA1B depolymerizes PubMed
    tubulin alpha-1C chain TUBA1C interacts with PubMed
    TUBA1C depolymerizes PubMed
    tubulin alpha-3C/D chain TUBA3C depolymerizes PubMed
    tubulin alpha-4A chain TUBA4A interacts with PubMed
    TUBA4A depolymerizes PubMed
    tubulin alpha-8 chain isoform 1 TUBA8 interacts with PubMed
    TUBA8 depolymerizes PubMed
    tubulin beta chain TUBB interacts with PubMed
    tubulin beta-1 chain TUBB1 depolymerizes PubMed
    tubulin beta-2A chain TUBB2A interacts with PubMed
    TUBB2A depolymerizes PubMed
    tubulin beta-2B chain TUBB2B interacts with PubMed
    tubulin beta-3 chain isoform 1 TUBB3 interacts with PubMed
    TUBB3 depolymerizes PubMed
    tubulin beta-4A chain TUBB4A interacts with PubMed
    TUBB4A depolymerizes PubMed
    tubulin beta-4B chain TUBB4B interacts with PubMed
    TUBB4B depolymerizes PubMed
    tubulin beta-6 chain TUBB6 depolymerizes PubMed
    tubulin beta-8 chain isoform 1 TUBB8 depolymerizes PubMed
    splicing factor U2AF 35 kDa subunit isoform a U2AF1 interacts with PubMed
    polyubiquitin-B precursor UBB ubiquitinated by PubMed
    polyubiquitin-C UBC ubiquitinated by PubMed
    ubiquitin D UBD ubiquitinated by PubMed
    E3 ubiquitin-protein ligase UBR4 UBR4 interacts with PubMed
    U4/U6.U5 tri-snRNP-associated protein 2 isoform 1 USP39 interacts with PubMed
    WD repeat-containing protein 3 WDR3 interacts with PubMed
    WD repeat-containing protein 36 WDR36 interacts with PubMed
    exportin-1 XPO1 regulated by PubMed
    XPO1 regulated by PubMed
    XPO1 interacts with PubMed
    XPO1 regulated by PubMed
    XPO1 exported by PubMed
    XPO1 enhanced by PubMed
    XPO1 modulated by PubMed
    XPO1 binds PubMed
    XPO1 binds PubMed
    XPO1 recruits PubMed
    XPO1 interacts with PubMed
    XPO1 interacts with PubMed
    XPO1 binds PubMed
    XPO1 binds PubMed
    XPO1 interacts with PubMed
    XPO1 interacts with PubMed
    XPO1 inhibited by PubMed
    XPO1 co-localizes with PubMed
    XPO1 interacts with PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_057854.1 NP_002256.2 KPNB1    BIND  PubMed Rev interacts with Imp-beta. 
    BioGRID:1205542 BioGRID:106541 ABCF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116634 ACIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:106617 ADAR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113791 ANP32A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115795 ANP32B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:117067 ANP32C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:123548 ANP32E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:106825 APEX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:106978 ATP2A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:119650 C14orf166    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:119569 C22orf28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:122525 C2orf49    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:107262 CALR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110252 CAPRIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:107424 CDC5L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:125612 CHCHD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:119826 CPSF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116238 CPSF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:122957 CPSF7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:107841 CSNK2A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:107842 CSNK2A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:107843 CSNK2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:107860 CSTF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:107861 CSTF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:117730 DAZAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108019 DDX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115776 DDX17    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:1205542 BioGRID:114625 DDX21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:1205542 BioGRID:121353 DDX24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108020 DDX3X    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:1205542 BioGRID:119375 DDX47    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:1205542 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:1205542 BioGRID:128022 DHX36    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:1205542 BioGRID:108025 DHX9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:1205542 BioGRID:108117 DYNC1H1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108237 EEF1A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114411 EIF2S2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108287 EIF2S3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114217 EIF3I    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115743 EIF3M    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115703 EMG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116569 EPN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108380 ERCC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108383 ERCC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108390 ERH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108431 EWSR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:119220 EXOSC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:121243 EXOSC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116658 EXOSC7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:129661 FAM98B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108491 FAU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108797 FUS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:108868 GAPDH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:120214 GPATCH4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116452 GPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:120884 H2AFJ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109273 H3F3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109271 HIST1H2BB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113943 HIST1H2BC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109270 HIST1H2BD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113941 HIST1H2BH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113936 HIST1H2BL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113938 HIST1H2BM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113937 HIST1H2BN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113945 HIST2H2BE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:136811 HIST2H2BF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:126106 HIST3H2BB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109346 HK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:128670 HNRNPA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109423 HNRNPAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109424 HNRNPC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109425 HNRNPD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109426 HNRNPF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109428 HNRNPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109429 HNRNPH2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109430 HNRNPH3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110751 HNRNPM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115530 HNRNPR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115308 HNRPDL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113036 HSP90B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115385 HUWE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109766 IK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109821 ILF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:109822 ILF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115782 IPO7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115900 KHDRBS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116684 KIF21B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110034 KPNA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110036 KPNA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110038 KPNA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:117163 KPNA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110035 KPNB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:1205542 BioGRID:110168 LIG3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115126 MATR3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110394 MFAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:126197 MITD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110490 MPG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:118800 MRPL42    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:118784 MRPS28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:122360 MRPS9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:121498 MRS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115770 MYBBP1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110754 NAP1L1    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:1205542 BioGRID:110757 NAP1L4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110758 NARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:117363 NIPBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:122308 NMNAT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110904 NONO    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:119631 NOP58    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:127790 NOP9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110954 NRD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113717 NUP214    BioGRID  PubMed Two-hybrid 
    BioGRID:1205542 BioGRID:32245 NUP42    BioGRID  PubMed Two-hybrid 
    BioGRID:1205542 BioGRID:33364 NUP57    BioGRID  PubMed Two-hybrid 
    BioGRID:1205542 BioGRID:110982 NUP98    BioGRID  PubMed Two-hybrid 
    BioGRID:1205542 BioGRID:116278 NUPL2    BioGRID  PubMed Two-hybrid 
    BioGRID:1205542 BioGRID:111073 P4HB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:117939 PABPC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:125115 PAXBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116633 PDCD11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111232 PFKL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111235 PFKP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111366 PLOD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111370 PLRG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116440 PNKP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115214 POM121    BioGRID  PubMed Two-hybrid 
    BioGRID:1205542 BioGRID:111441 PON2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:121141 PPAN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111475 PPIB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111512 PPP2R2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:120946 PPP2R2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111529 PPP6C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:118151 PRPF19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:117563 PRPF31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114416 PRPF4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:117298 PRPF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115842 PRPF8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:120558 PSPC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115952 PTGES3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111773 PURB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111837 RAN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111840 RANGAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:122293 RBM15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114952 RBM39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:122588 RBM42    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:111897 RECQL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112059 RPL17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114752 RPL23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112074 RPL27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112042 RPL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112080 RPL32    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112084 RPL35A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112048 RPL6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112132 RPS17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112101 RPS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112142 RPS23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112144 RPS25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112147 RPS27A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112103 RPS3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112105 RPS4X    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112107 RPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112108 RPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110115 RPSA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112201 SAFB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115580 SF3A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113826 SF3A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116146 SF3A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112319 SFPQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:117064 SKIV2L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:120528 SMU1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116661 SNRNP200    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114805 SNRNP40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112509 SNRNP70    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112515 SNRPC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112519 SNRPE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112520 SNRPF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112521 SNRPG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:122410 SPATS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112589 SPTBN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:120439 SRBD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112607 SRP54    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112604 SRP9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114231 SRSF9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112619 SSB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:112620 SSBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116162 STIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116127 SUB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116367 SUPT16H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115755 SYNCRIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:122605 THOC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116169 TMED10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:128780 TMED4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:120115 TMED9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:110040 TNPO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:125269 TOE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:114730 TRIP13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:123562 TRMT1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113603 TUBA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115651 TUBA1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:124259 TUBA1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113128 TUBA4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:119733 TUBA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:128444 TUBB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113131 TUBB2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:131483 TUBB2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115654 TUBB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115655 TUBB4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115656 TUBB4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113157 U2AF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:1205542 BioGRID:116934 UBR4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:115939 USP39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:116092 WDR3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:126399 WDR36    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:1205542 BioGRID:113348 XPO1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:1205542 BioGRID:1205542 rev    BioGRID  PubMed FRET 
    • 2-LTR circle formation, organism-specific biosystem (from REACTOME)
      2-LTR circle formation, organism-specific biosystemThe formation of 2-LTR circles requires the action of the cellular non-homologous DNA end-joining pathway. Specifically the cellular Ku, XRCC4 and ligase IV proteins are needed. Evidence for this i...
    • APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystem (from REACTOME)
      APOBEC3G mediated resistance to HIV-1 infection, organism-specific biosystemRepresentatives of the apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3) family provide innate resistance to exogeneous and endogenous retroviruses (see Cullen 2006 for a recent ...
    • Autointegration results in viral DNA circles, organism-specific biosystem (from REACTOME)
      Autointegration results in viral DNA circles, organism-specific biosystemIn this pathway, the viral integration machinery uses a site within the viral DNA as an integration target. This results in a covalent rearrangment of the viral DNA. The resulting DNA forms are no...
    • Binding and entry of HIV virion, organism-specific biosystem (from REACTOME)
      Binding and entry of HIV virion, organism-specific biosystemHIV enters cells by fusion at the cell surface, that results in a productive infection. The envelope (Env) protein of HIV mediates entry. Env is composed of a surface subunit, gp120, and a transmemb...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Early Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Early Phase of HIV Life Cycle, organism-specific biosystemIn the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • Integration of provirus, organism-specific biosystem (from REACTOME)
      Integration of provirus, organism-specific biosystemFor retroviral DNA to direct production of progeny virions it must become covalently integrated into the host cell chromosome (reviewed in Coffin et al. 1997; Hansen et al. 1998). Analyses of mutants...
    • Integration of viral DNA into host genomic DNA, organism-specific biosystem (from REACTOME)
      Integration of viral DNA into host genomic DNA, organism-specific biosystemFollowing nuclear entry, the viral preintegration complex (PIC) must select a site for integration in a host cell chromosome, and then carry out the chemical steps of the reaction. At the chromosomal...
    • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
    • Interactions of Vpr with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Vpr with host cellular proteins, organism-specific biosystemVpr has been implicated in multiple processes during HIV-1 replication, including nuclear import of the pre-integration complex (PIC)(Heinzinger et al., 1994), apoptosis (Stewart et al., 1997) and in...
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
    • Minus-strand DNA synthesis, organism-specific biosystem (from REACTOME)
      Minus-strand DNA synthesis, organism-specific biosystemIn the first part of reverse transcription, minus-strand synthesis, a DNA strand complementary to the HIV genomic RNA is synthesized, using the viral RNA as a template and a host cell lysine tRNA mol...
    • Plus-strand DNA synthesis, organism-specific biosystem (from REACTOME)
      Plus-strand DNA synthesis, organism-specific biosystemTwo specific polypurine tracts (PPT sequences) in the viral RNA, one within the pol gene (central or cPPT) and one immediately preceding the U3 sequence (3' PPT), are spared from degradation during m...
    • Rev-mediated nuclear export of HIV-1 RNA, organism-specific biosystem (from REACTOME)
      Rev-mediated nuclear export of HIV-1 RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
    • Reverse Transcription of HIV RNA, organism-specific biosystem (from REACTOME)
      Reverse Transcription of HIV RNA, organism-specific biosystemThe RNA genome of HIV-1, like that of other retroviruses, is reverse-transcribed (Baltimore 1970; Temin and Mizutani 1970) into double-stranded DNA, which is then integrated into a host cell chromoso...
    • Uncoating of the HIV Virion, organism-specific biosystem (from REACTOME)
      Uncoating of the HIV Virion, organism-specific biosystemHIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, t...
    • Vpr-mediated nuclear import of PICs, organism-specific biosystem (from REACTOME)
      Vpr-mediated nuclear import of PICs, organism-specific biosystemVpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins.
    Preferred Names
    p19
    Names
    Rev

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001802.1

      Range
      5516..8199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_057854.1 Rev [Human immunodeficiency virus 1]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04618
      UniProtKB/TrEMBL
      Q77YF8
      Conserved Domains (1) summary
      pfam00424
      Location:4 – 92
      Blast Score: 218
      REV; REV protein (anti-repression trans-activator protein)
    Nucleotide Protein
    Heading Accession and Version
    genomic AF033819.3 AAC82592.1
    genomic K03455.1 AAB50257.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q77YF8.1 GenPept

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content

      Table of contents

      Related information

      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • Taxonomy
        Link to related taxonomy entry

      General information

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