GeneRIFs: Gene References Into Functions What's a GeneRIF?

1. deregulation of neuronal functions by HIV-1 Tat protein is miRNA-dependent
   Title: HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs.
2. HIV-1 proteins are capable of producing pain signaling through direct actions on excitability and survival of sensory neurons
   Title: Direct effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain.
3. HIV-1 Tat can lead to long-lasting disruption of normal neuroimmune homeost
   Title: HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells.
4. Nef suppresses Hsp70-mediated HIV-1 Tat activation
   Title: Human immunodeficiency virus-1 Nef suppresses Hsp70-mediated Tat activation.
5. NFkB/HDAC1 pathway may have an important role in regulating HIV-1 Tat-induced long terminal repeat transactivation and is inhibited by curcumin.
   Title: HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.
6. Tat treatment of primary cultures of differentiated human neurons with significant amounts of N-methyl-D-aspartate receptor (NMDAR) expression induces extensive apoptosis.
   Title: Differences in NMDA receptor expression during human development determine the response of neurons to HIV-tat-mediated neurotoxicity.
7. The Tat/Grb2 interaction affects also viral function by inhibiting the Tat-mediated transactivation of HIV-1 LTR and viral replication in infected primary microglia.
   Title: HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction.
8. This review describes the easy detection of recombinant Tat-Ngb in the brain 4 h after intravenous application, while Ngb without cell-penetrating peptide does not transduce the brain parenchyma
   Title: Protection by neuroglobin and cell-penetrating peptide-mediated delivery in vivo: a decade of research. Comment on Cai et al: TAT-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice. Exp Neurol. 2011; 227(1): 224-31.
9. These results indicate that Tat has a versatile role in transcription via TAR and U3 elements.
   Title: The HIV-1 Tat protein has a versatile role in activating viral transcription.
10. The distinct ring morphology of the HIV-1 5' untranslated region includes the dimer formed from RNAs containing HIV-1 nucleotides 1-744; dimer morphology implies a dimerization initiation site, 3' dimer linkage site, and TAR-TAR transactivation region.
    Title: Structure of the HIV-1 5' untranslated region dimer alone and in complex with gold nanocolloids: support of a TAR-TAR-containing 5' dimer linkage site (DLS) and a 3' DIS-DIS-containing DLS.