GeneRIFs: Gene References Into Functions What's a GeneRIF?

1. findings suggest that Gag cytotoxic T lymphocyte mutations may influence HIV-1 replication by modifying both viral infectivity and sensitivity to TRIM5alpha
   Title: Gag cytotoxic T lymphocyte escape mutations can increase sensitivity of HIV-1 to human TRIM5alpha, linking intrinsic and acquired immunity.
2. The distinct patterns in the spectrum and dynamics of reverse and forward Gag substitutions suggest that these differences should be considered in HIV-1 evolutionary studies and analyses of viral mutational pathways.
   Title: Evolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection.
3. Monomeric mutant capsid protein (CA) of HIV-1, though not infective, retains many of the critical properties of the wild-type CA even though it exists as a monomer in solution.
   Title: Structure of a monomeric mutant of the HIV-1 capsid protein.
4. The authors found that membrane-bound Gag induces the coalescence of lipid rafts and tetraspanin-enriched microdomains.
   Title: Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane.
5. Spry2 influences IP3R function through control of PI(4,5)P(2) and IP3R influences Spry2 function by controlling its distribution and ERK activation.
   Title: Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.
6. The interaction of MAPK/ERK-2 with Gag polyprotein results in its incorporation into virus particles and may be essential for retroviral replication.
   Title: Mechanism of host cell MAPK/ERK-2 incorporation into lentivirus particles: characterization of the interaction between MAPK/ERK-2 and proline-rich-domain containing capsid region of structural protein Gag.
7. These results indicate that the matrix RNA and PI(4,5)P(2) binding sites overlap and suggest models for Gag-membrane and Gag-RNA interactions and for the HIV assembly pathway.
   Title: HIV-1 matrix protein binding to RNA.
8. This review highlights current knowledge on viral and cellular determinants that affect specific interactions between Gag and the plasma membrane.
   Title: Molecular determinants that regulate plasma membrane association of HIV-1 Gag.
9. HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production.
   Title: HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production.
10. Since erythrocyte-associated p24-antigen is not always related to pVL or p24-antigen in plasma, erythrocyte-associated p24-antigen showed viral expression not represented in plasma.
    Title: Presence of p24-antigen associated to erythrocyte in HIV-positive individuals even in patients with undetectable plasma viral load.