U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant neoplastic disease

MedGen UID:
14297
Concept ID:
C0006826
Neoplastic Process
Synonym: Cancer
SNOMED CT: Malignant neoplastic disease (363346000); Cancer (363346000); CA - Cancer (363346000); Malignant neoplasm (363346000); Malignant tumor (363346000); Malignant neoplasm morphology (1240414004); Malignancy (1240414004); Malignant tumor (1240414004); Blastoma (1240414004); Malignant neoplasm (1240414004); Cancer (1240414004); Unclassified malignant tumor (1240414004)
 
Monarch Initiative: MONDO:0004992

Definition

A neoplasm composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Malignant neoplastic disease

Professional guidelines

PubMed

Kumar P, Kadakol A, Shasthrula PK, Mundhe NA, Jamdade VS, Barua CC, Gaikwad AB
Anticancer Agents Med Chem 2015;15(5):647-56. doi: 10.2174/1871520615666150101125918. PMID: 25553436
Beauchesne P
Lancet Oncol 2010 Sep;11(9):871-9. Epub 2010 Jul 2 doi: 10.1016/S1470-2045(10)70034-6. PMID: 20598636

Curated

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Suggested Reading

Recent clinical studies

Etiology

Soria S, Buckberry J
Int J Paleopathol 2022 Sep;38:32-40. Epub 2022 Jun 23 doi: 10.1016/j.ijpp.2022.05.007. PMID: 35753114
Nogueras López F, Espinosa Aguilar MD, Abellán Alfocea P, Ortega Suazo EJ, González Sánchez M, Redondo Cerezo E, López Garrido MA
Transplant Proc 2020 Mar;52(2):553-555. Epub 2020 Feb 5 doi: 10.1016/j.transproceed.2019.12.011. PMID: 32035682
Qin X, Zhang MY, Liu WJ
Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6885-6895. doi: 10.26355/eurrev_201810_16158. PMID: 30402854
Rzechonek A, Błasiak P, Pniewski G, Cierpikowski P, Mościbrodzka M, Ornat M, Grzegrzółka J, Brzecka A
In Vivo 2018 Jan-Feb;32(1):197-202. doi: 10.21873/invivo.11225. PMID: 29275320Free PMC Article
Szudy-Szczyrek A, Szczyrek M, Soroka-Wojtaszko M, Hus M
Postepy Hig Med Dosw (Online) 2016 Jan 4;70(0):811-9. doi: 10.5604/17322693.1211183. PMID: 27463592

Diagnosis

Avella P, Vaschetti R, Cappuccio M, Gambale F, DE Meis L, Rafanelli F, Brunese MC, Guerra G, Scacchi A, Rocca A
Minerva Surg 2022 Dec;77(6):582-590. doi: 10.23736/S2724-5691.22.09716-7. PMID: 36409039
Soria S, Buckberry J
Int J Paleopathol 2022 Sep;38:32-40. Epub 2022 Jun 23 doi: 10.1016/j.ijpp.2022.05.007. PMID: 35753114
Qin X, Zhang MY, Liu WJ
Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6885-6895. doi: 10.26355/eurrev_201810_16158. PMID: 30402854
Berton G, Cordiano R, Cavuto F, Bagato F, Segafredo B, Pasquinucci M
J Cardiovasc Med (Hagerstown) 2018 Oct;19(10):546-553. doi: 10.2459/JCM.0000000000000701. PMID: 30119096
Szudy-Szczyrek A, Szczyrek M, Soroka-Wojtaszko M, Hus M
Postepy Hig Med Dosw (Online) 2016 Jan 4;70(0):811-9. doi: 10.5604/17322693.1211183. PMID: 27463592

Therapy

Avella P, Vaschetti R, Cappuccio M, Gambale F, DE Meis L, Rafanelli F, Brunese MC, Guerra G, Scacchi A, Rocca A
Minerva Surg 2022 Dec;77(6):582-590. doi: 10.23736/S2724-5691.22.09716-7. PMID: 36409039
Nogueras López F, Espinosa Aguilar MD, Abellán Alfocea P, Ortega Suazo EJ, González Sánchez M, Redondo Cerezo E, López Garrido MA
Transplant Proc 2020 Mar;52(2):553-555. Epub 2020 Feb 5 doi: 10.1016/j.transproceed.2019.12.011. PMID: 32035682
Warner BM, Baer AN, Lipson EJ, Allen C, Hinrichs C, Rajan A, Pelayo E, Beach M, Gulley JL, Madan RA, Feliciano J, Grisius M, Long L, Powers A, Kleiner DE, Cappelli L, Alevizos I
Oncologist 2019 Sep;24(9):1259-1269. Epub 2019 Apr 17 doi: 10.1634/theoncologist.2018-0823. PMID: 30996010Free PMC Article
Szudy-Szczyrek A, Szczyrek M, Soroka-Wojtaszko M, Hus M
Postepy Hig Med Dosw (Online) 2016 Jan 4;70(0):811-9. doi: 10.5604/17322693.1211183. PMID: 27463592
Kumar P, Kadakol A, Shasthrula PK, Mundhe NA, Jamdade VS, Barua CC, Gaikwad AB
Anticancer Agents Med Chem 2015;15(5):647-56. doi: 10.2174/1871520615666150101125918. PMID: 25553436

Prognosis

Soria S, Buckberry J
Int J Paleopathol 2022 Sep;38:32-40. Epub 2022 Jun 23 doi: 10.1016/j.ijpp.2022.05.007. PMID: 35753114
Qureshi A, Michel M, Lerner J, Dasanu CA
Expert Opin Pharmacother 2021 Dec;22(18):2495-2506. Epub 2021 Jul 15 doi: 10.1080/14656566.2021.1953473. PMID: 34252328
Qin X, Zhang MY, Liu WJ
Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6885-6895. doi: 10.26355/eurrev_201810_16158. PMID: 30402854
Berton G, Cordiano R, Cavuto F, Bagato F, Segafredo B, Pasquinucci M
J Cardiovasc Med (Hagerstown) 2018 Oct;19(10):546-553. doi: 10.2459/JCM.0000000000000701. PMID: 30119096
Szudy-Szczyrek A, Szczyrek M, Soroka-Wojtaszko M, Hus M
Postepy Hig Med Dosw (Online) 2016 Jan 4;70(0):811-9. doi: 10.5604/17322693.1211183. PMID: 27463592

Clinical prediction guides

Soria S, Buckberry J
Int J Paleopathol 2022 Sep;38:32-40. Epub 2022 Jun 23 doi: 10.1016/j.ijpp.2022.05.007. PMID: 35753114
Qureshi A, Michel M, Lerner J, Dasanu CA
Expert Opin Pharmacother 2021 Dec;22(18):2495-2506. Epub 2021 Jul 15 doi: 10.1080/14656566.2021.1953473. PMID: 34252328
Nogueras López F, Espinosa Aguilar MD, Abellán Alfocea P, Ortega Suazo EJ, González Sánchez M, Redondo Cerezo E, López Garrido MA
Transplant Proc 2020 Mar;52(2):553-555. Epub 2020 Feb 5 doi: 10.1016/j.transproceed.2019.12.011. PMID: 32035682
Qin X, Zhang MY, Liu WJ
Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6885-6895. doi: 10.26355/eurrev_201810_16158. PMID: 30402854
Berton G, Cordiano R, Cavuto F, Bagato F, Segafredo B, Pasquinucci M
J Cardiovasc Med (Hagerstown) 2018 Oct;19(10):546-553. doi: 10.2459/JCM.0000000000000701. PMID: 30119096

Recent systematic reviews

Zou Y, Li B, Wang X, Mao J, Zhang Y
Medicine (Baltimore) 2022 Dec 2;101(48):e31991. doi: 10.1097/MD.0000000000031991. PMID: 36482589Free PMC Article
Hunt KJ, Roberts C, Kirkpatrick C
Int J Paleopathol 2018 Jun;21:12-26. doi: 10.1016/j.ijpp.2018.03.002. PMID: 29773338

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...