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Gastrointestinal carcinoma

MedGen UID:
57467
Concept ID:
C0151544
Neoplastic Process
Synonyms: Carcinoma of the Gastrointestinal System; Digestive System Carcinoma; Gastrointestinal Carcinoma; Gastrointestinal System Carcinoma
 
HPO: HP:0002672

Definition

A malignant neoplasm that arises from the epithelium of any part of the gastrointestinal system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastrointestinal carcinoma

Conditions with this feature

Peutz-Jeghers syndrome
MedGen UID:
18404
Concept ID:
C0031269
Disease or Syndrome
Peutz-Jeghers syndrome (PJS) is an autosomal dominant condition characterized by the association of gastrointestinal polyposis, mucocutaneous pigmentation, and cancer predisposition. Peutz-Jeghers-type hamartomatous polyps are most common in the small intestine (in order of prevalence: in the jejunum, ileum, and duodenum) but can also occur in the stomach, large bowel, and extraintestinal sites including the renal pelvis, bronchus, gall bladder, nasal passages, urinary bladder, and ureters. Gastrointestinal polyps can result in chronic bleeding and anemia and also cause recurrent obstruction and intussusception requiring repeated laparotomy and bowel resection. Mucocutaneous hyperpigmentation presents in childhood as dark blue to dark brown macules around the mouth, eyes, and nostrils, in the perianal area, and on the buccal mucosa. Hyperpigmented macules on the fingers are common. The macules may fade in puberty and adulthood. Individuals with Peutz-Jeghers syndrome are at increased risk for a wide variety of epithelial malignancies (colorectal, gastric, pancreatic, breast, and ovarian cancers). Females are at risk for sex cord tumors with annular tubules (SCTAT), a benign neoplasm of the ovaries, and adenoma malignum of the cervix, a rare aggressive cancer. Males occasionally develop large calcifying Sertoli cell tumors (LCST) of the testes, which secrete estrogen and can lead to gynecomastia, advanced skeletal age, and ultimately short stature, if untreated.
Cronkhite-Canada syndrome
MedGen UID:
129128
Concept ID:
C0282207
Disease or Syndrome
Cronkhite-Canada syndrome is characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, skin hyperpigmentation, and diarrhea. It is associated with high morbidity (summary by Sweetser et al., 2012).
Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome
MedGen UID:
331400
Concept ID:
C1832942
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Telangiectases (small AVMs) are most evident on the lips, tongue, buccal mucosa, face, chest, and fingers. The average age of onset is generally later than epistaxis, but may be during childhood. Large AVMs often cause symptoms when they occur in the lungs, liver, or brain; complications from bleeding or shunting may be sudden and catastrophic. Approximately 25% of individuals with HHT have GI bleeding, which most commonly begins after age 50 years.

Recent clinical studies

Etiology

Zareba K, Czygier M, Kamocki Z, Cepowicz D, Szmitkowski M, Kedra B
Adv Med Sci 2013;58(1):150-5. doi: 10.2478/v10039-012-0059-x. PMID: 23612677
Takiguchi N, Nagata M, Soda H, Nomura Y, Takayama W, Yasutomi J, Tohyama Y, Ryu M
Surg Today 2010 Nov;40(11):1050-4. Epub 2010 Nov 3 doi: 10.1007/s00595-009-4234-z. PMID: 21046504
Amikura K, Sakamoto H, Yatsuoka T, Kawashima Y, Nishimura Y, Tanaka Y
J Surg Oncol 2010 Mar 1;101(3):228-32. doi: 10.1002/jso.21463. PMID: 20039277
Shao YS, Zhang YT, Peng KQ, Quan ZY
World J Gastroenterol 2005 Mar 21;11(11):1577-81. PMID: 15786530Free PMC Article
Kunimoto Y, Nakamura T, Ohno M, Kuroda Y
Oncol Rep 2004 Dec;12(6):1163-7. PMID: 15547732

Diagnosis

De Voogd FA, Gearry RB, Mulder CJ, Day AS
J Gastroenterol Hepatol 2016 Aug;31(8):1386-92. doi: 10.1111/jgh.13324. PMID: 26896745
Routhier CA, Mochel MC, Lynch K, Dias-Santagata D, Louis DN, Hoang MP
Hum Pathol 2013 Nov;44(11):2563-70. Epub 2013 Sep 24 doi: 10.1016/j.humpath.2013.06.018. PMID: 24071017
Zareba K, Czygier M, Kamocki Z, Cepowicz D, Szmitkowski M, Kedra B
Adv Med Sci 2013;58(1):150-5. doi: 10.2478/v10039-012-0059-x. PMID: 23612677
Shimada M, Berjohn C, Tanen DA
J Emerg Med 2013 Feb;44(2):e195-8. Epub 2012 Jul 4 doi: 10.1016/j.jemermed.2012.02.060. PMID: 22766406
Zaręba K, Bandurski R, Kędra B
Pol Przegl Chir 2012 Jun;84(6):317-21. doi: 10.2478/v10035-012-0053-9. PMID: 22842745

Therapy

Amini A, Masoumi-Moghaddam S, Ehteda A, Liauw W, Morris DL
Oncotarget 2015 Oct 20;6(32):33329-44. doi: 10.18632/oncotarget.5259. PMID: 26436698Free PMC Article
Zareba K, Czygier M, Kamocki Z, Cepowicz D, Szmitkowski M, Kedra B
Adv Med Sci 2013;58(1):150-5. doi: 10.2478/v10039-012-0059-x. PMID: 23612677
Malvicini M, Ingolotti M, Piccioni F, Garcia M, Bayo J, Atorrasagasti C, Alaniz L, Aquino JB, Espinoza JA, Gidekel M, Scharovsky OG, Matar P, Mazzolini G
Mol Oncol 2011 Jun;5(3):242-55. Epub 2011 Apr 5 doi: 10.1016/j.molonc.2011.03.007. PMID: 21515097
Takiguchi N, Nagata M, Soda H, Nomura Y, Takayama W, Yasutomi J, Tohyama Y, Ryu M
Surg Today 2010 Nov;40(11):1050-4. Epub 2010 Nov 3 doi: 10.1007/s00595-009-4234-z. PMID: 21046504
Ree AH, Dueland S, Folkvord S, Hole KH, Seierstad T, Johansen M, Abrahamsen TW, Flatmark K
Lancet Oncol 2010 May;11(5):459-64. Epub 2010 Apr 6 doi: 10.1016/S1470-2045(10)70058-9. PMID: 20378407

Prognosis

De Voogd FA, Gearry RB, Mulder CJ, Day AS
J Gastroenterol Hepatol 2016 Aug;31(8):1386-92. doi: 10.1111/jgh.13324. PMID: 26896745
Shintani M, Sangawa A, Yamao N, Kamoshida S
Int J Clin Exp Pathol 2013;6(12):2919-27. Epub 2013 Nov 15 PMID: 24294379Free PMC Article
Amikura K, Sakamoto H, Yatsuoka T, Kawashima Y, Nishimura Y, Tanaka Y
J Surg Oncol 2010 Mar 1;101(3):228-32. doi: 10.1002/jso.21463. PMID: 20039277
Yasuda N, Nakashima O, Ohnaka T, Kamisaka K, Tsunoda A, Kusano M
Surg Today 2006;36(1):25-9. doi: 10.1007/s00595-005-3091-7. PMID: 16378189
Friederichs J, Gertler R, Rosenberg R, Nahrig J, Führer K, Holzmann B, Dittler HJ, Dahm M, Thorban S, Nekarda H, Siewert JR
World J Surg 2005 Apr;29(4):422-8. doi: 10.1007/s00268-004-7662-3. PMID: 15770378

Clinical prediction guides

De Voogd FA, Gearry RB, Mulder CJ, Day AS
J Gastroenterol Hepatol 2016 Aug;31(8):1386-92. doi: 10.1111/jgh.13324. PMID: 26896745
Zareba K, Czygier M, Kamocki Z, Cepowicz D, Szmitkowski M, Kedra B
Adv Med Sci 2013;58(1):150-5. doi: 10.2478/v10039-012-0059-x. PMID: 23612677
Ree AH, Dueland S, Folkvord S, Hole KH, Seierstad T, Johansen M, Abrahamsen TW, Flatmark K
Lancet Oncol 2010 May;11(5):459-64. Epub 2010 Apr 6 doi: 10.1016/S1470-2045(10)70058-9. PMID: 20378407
Carvalho AS, Harduin-Lepers A, Magalhães A, Machado E, Mendes N, Costa LT, Matthiesen R, Almeida R, Costa J, Reis CA
Int J Biochem Cell Biol 2010 Jan;42(1):80-9. Epub 2009 Sep 23 doi: 10.1016/j.biocel.2009.09.010. PMID: 19781661
Yasuda N, Nakashima O, Ohnaka T, Kamisaka K, Tsunoda A, Kusano M
Surg Today 2006;36(1):25-9. doi: 10.1007/s00595-005-3091-7. PMID: 16378189

Recent systematic reviews

Shen X, Wang J, Yan X, Ren X, Wang F, Chen X, Xu Y
Cancer Chemother Pharmacol 2016 Jun;77(6):1285-302. Epub 2016 May 6 doi: 10.1007/s00280-016-3047-1. PMID: 27154175
Luo Y, Zhang X, Tan Z, Wu P, Xiang X, Dang Y, Chen G
PLoS One 2015;10(12):e0145659. Epub 2015 Dec 28 doi: 10.1371/journal.pone.0145659. PMID: 26710214Free PMC Article
Delaney G, Barton M, Jacob S
Cancer 2004 Aug 15;101(4):657-70. doi: 10.1002/cncr.20443. PMID: 15305395
Sung L, Greenberg ML, Koren G, Tomlinson GA, Tong A, Malkin D, Feldman BM
Nutr Cancer 2003;46(1):1-14. doi: 10.1207/S15327914NC4601_01. PMID: 12925298
Lekse JM, Zhang J, Mawn LA
Ophthalmology 2003 Feb;110(2):318-21. doi: 10.1016/S0161-6420(02)01559-2. PMID: 12578774

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