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Meningeal melanomatosis

MedGen UID:
226843
•Concept ID:
C1266114
•
Neoplastic Process
Synonyms: Leptomeningeal Melanomatosis; leptomeningeal melanomatosis; melanomatosis of meningeal cluster; meningeal cluster melanomatosis; Meningeal Melanomatosis; meningeal melanomatosis; meningeal melanomatosis (morphologic abnormality)
SNOMED CT: Meningeal melanomatosis (128731008)
 
Monarch Initiative: MONDO:0004512

Definition

A meningeal melanoma with secondary diffuse meningeal spread. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningeal melanomatosis

Recent clinical studies

Etiology

Spectrum of Clinical, Neuroimaging, and Cerebrospinal Fluid Features of Adult Neurocutaneous Melanocytosis.
Qian M, Ren H, Qu T, Lu Z, Zou Y, He J, Zhao Y, Chen L, Guan H
Eur Neurol 2018;80(1-2):1-6. Epub 2018 Jul 13 doi: 10.1159/000488687. PMID: 30007971
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission.
Grätz V, Lüttmann N, Haase O, Langan EA, Kemmling A, Zillikens D, Terheyden P
Melanoma Res 2017 Oct;27(5):503-506. doi: 10.1097/CMR.0000000000000373. PMID: 28723725
Meningeal melanomatosis: a challenge for timely diagnosis.
Berzero G, Diamanti L, Di Stefano AL, Bini P, Franciotta D, Imarisio I, Pedrazzoli P, Magrassi L, Morbini P, Farina LM, Bastianello S, Ceroni M, Marchioni E
Biomed Res Int 2015;2015:948497. Epub 2015 Jan 14 doi: 10.1155/2015/948497. PMID: 25648721Free PMC Article
Pigmented lesions of the central nervous system: radiologic-pathologic correlation.
Smith AB, Rushing EJ, Smirniotopoulos JG
Radiographics 2009 Sep-Oct;29(5):1503-24. doi: 10.1148/rg.295095109. PMID: 19755608
Cranial computed tomography of malignant melanoma.
Ginaldi S, Wallace S, Shalen P, Luna M, Handel S
AJR Am J Roentgenol 1981 Jan;136(1):145-9. doi: 10.2214/ajr.136.1.145. PMID: 6779562

Diagnosis

Primary Diffuse Meningeal Melanomatosis.
Wen L, Cai L
N Engl J Med 2023 May 18;388(20):1892. Epub 2023 May 13 doi: 10.1056/NEJMicm2212333. PMID: 37183981
Meningeal Melanomatosis with a Spinal Meningeal Melanocytoma Trigger by an in vitro Fertilization.
Ramos AA, Ferrara P, Fernández VM, Sanchez CR, Alvarez Vega MA
Neurol India 2022 Sep-Oct;70(Supplement):S318-S321. doi: 10.4103/0028-3886.360914. PMID: 36412389
Brain Atrophy Associated with Primary Diffuse Meningeal Melanomatosis.
Ma Y, Xing X, Li Y, Ao R, He M, Lan X, Zhao Y, Zhang J, Yu S
World Neurosurg 2020 Apr;136:311-314. Epub 2020 Jan 29 doi: 10.1016/j.wneu.2020.01.164. PMID: 32004738
Primary diffuse meningeal melanomatosis - a rare form of meningeal melanoma: case report.
Garbacz T, Osuchowski M, Bartosik-Psujek H
BMC Neurol 2019 Nov 5;19(1):271. doi: 10.1186/s12883-019-1460-x. PMID: 31690266Free PMC Article
Pigmented lesions of the central nervous system: radiologic-pathologic correlation.
Smith AB, Rushing EJ, Smirniotopoulos JG
Radiographics 2009 Sep-Oct;29(5):1503-24. doi: 10.1148/rg.295095109. PMID: 19755608

Therapy

Meningeal Melanomatosis with a Spinal Meningeal Melanocytoma Trigger by an in vitro Fertilization.
Ramos AA, Ferrara P, Fernández VM, Sanchez CR, Alvarez Vega MA
Neurol India 2022 Sep-Oct;70(Supplement):S318-S321. doi: 10.4103/0028-3886.360914. PMID: 36412389
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission.
Grätz V, Lüttmann N, Haase O, Langan EA, Kemmling A, Zillikens D, Terheyden P
Melanoma Res 2017 Oct;27(5):503-506. doi: 10.1097/CMR.0000000000000373. PMID: 28723725

Prognosis

Meningeal Melanomatosis with a Spinal Meningeal Melanocytoma Trigger by an in vitro Fertilization.
Ramos AA, Ferrara P, Fernández VM, Sanchez CR, Alvarez Vega MA
Neurol India 2022 Sep-Oct;70(Supplement):S318-S321. doi: 10.4103/0028-3886.360914. PMID: 36412389
Primary diffuse meningeal melanomatosis - a rare form of meningeal melanoma: case report.
Garbacz T, Osuchowski M, Bartosik-Psujek H
BMC Neurol 2019 Nov 5;19(1):271. doi: 10.1186/s12883-019-1460-x. PMID: 31690266Free PMC Article
F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis.
Lee HJ, Ahn BC, Hwang SW, Cho SK, Kim HW, Lee SW, Hwang JH, Lee J
Korean J Radiol 2013 Mar-Apr;14(2):343-9. Epub 2013 Feb 22 doi: 10.3348/kjr.2013.14.2.343. PMID: 23483049Free PMC Article
Primary diffuse meningeal melanomatosis.
Zadro I, Brinar VV, Barun B, Ozretić D, Pazanin L, Grahovac G, Habek M
Neurologist 2010 Mar;16(2):117-9. doi: 10.1097/NRL.0b013e3181c29ef8. PMID: 20220448
Primary leptomeningeal melanoma.
Schneider F, Putzier M
Spine (Phila Pa 1976) 2002 Dec 15;27(24):E545-7. doi: 10.1097/00007632-200212150-00026. PMID: 12486366

Clinical prediction guides

Imaging and Clinical Features of Neurocutaneous Melanosis in the Pediatric Population.
Mormina E, Granata F, Vinci SL, Coglitore A, Caragliano AA, Tessitore A, Longo M, Visalli C
Curr Med Imaging 2021;17(12):1391-1402. doi: 10.2174/1573405617666210527091109. PMID: 34047260
Brain Atrophy Associated with Primary Diffuse Meningeal Melanomatosis.
Ma Y, Xing X, Li Y, Ao R, He M, Lan X, Zhao Y, Zhang J, Yu S
World Neurosurg 2020 Apr;136:311-314. Epub 2020 Jan 29 doi: 10.1016/j.wneu.2020.01.164. PMID: 32004738
Meningeal melanomatosis following discontinuation of dabrafenib: implications for the maintenance of long-term complete remission.
Grätz V, Lüttmann N, Haase O, Langan EA, Kemmling A, Zillikens D, Terheyden P
Melanoma Res 2017 Oct;27(5):503-506. doi: 10.1097/CMR.0000000000000373. PMID: 28723725
Meningeal melanomatosis: a challenge for timely diagnosis.
Berzero G, Diamanti L, Di Stefano AL, Bini P, Franciotta D, Imarisio I, Pedrazzoli P, Magrassi L, Morbini P, Farina LM, Bastianello S, Ceroni M, Marchioni E
Biomed Res Int 2015;2015:948497. Epub 2015 Jan 14 doi: 10.1155/2015/948497. PMID: 25648721Free PMC Article
Extensive metastatic leptomeningeal melanomatosis as the first clinical sign of a cutaneous melanoma: morphological correlations between magnetic resonance imaging and autopsy findings. A case report.
Bussani R, Cova M, Pozzi-Mucelli R, Camilot D, Silvestri F
Hum Pathol 2003 Jun;34(6):625-8. doi: 10.1016/s0046-8177(03)00120-5. PMID: 12827619

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