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Myelodysplastic/myeloproliferative neoplasm

MedGen UID:
226981
Concept ID:
C1301355
Neoplastic Process
Synonyms: Disease, Myelodysplastic-Myeloproliferative; Disease, Myeloproliferative-Myelodisplastic; Diseases, Myelodysplastic-Myeloproliferative; Diseases, Myeloproliferative-Myelodisplastic; Myelodysplastic Myeloproliferative Diseases; Myelodysplastic-Myeloproliferative Disease; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Myelodisplastic Diseases; Myeloproliferative-Myelodisplastic Disease; Myeloproliferative-Myelodisplastic Diseases
SNOMED CT: Myelodysplastic/myeloproliferative disease (397336008); Myelodysplastic/myeloproliferative disease (445738007); Myelodysplastic-myeloproliferative neoplasm (397336008)
 
Monarch Initiative: MONDO:0006311

Definition

A category of clonal hematopoietic disorders that have both myelodysplastic and myeloproliferative features at the time of initial presentation. [from NCI]

Professional guidelines

PubMed

Sastow D, Syal A, Tremblay D
Curr Hematol Malig Rep 2025 Jul 4;20(1):8. doi: 10.1007/s11899-025-00753-2. PMID: 40613931
Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023

Recent clinical studies

Etiology

Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Prakash S, Arber DA, Bueso-Ramos C, Hasserjian RP, Orazi A
Virchows Arch 2023 Jan;482(1):69-83. Epub 2022 Dec 5 doi: 10.1007/s00428-022-03465-7. PMID: 36469102
Hunter AM, Padron E
Best Pract Res Clin Haematol 2020 Sep;33(3):101195. Epub 2020 Jul 5 doi: 10.1016/j.beha.2020.101195. PMID: 33038984
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article

Diagnosis

Patwardhan PP, Aarabi M, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):195-201. Epub 2023 Apr 12 doi: 10.1053/j.semdp.2023.04.005. PMID: 37105794
Patnaik MM, Tefferi A
Am J Hematol 2023 Apr;98(4):681-689. Epub 2023 Jan 4 doi: 10.1002/ajh.26828. PMID: 36601682
Prakash S, Arber DA, Bueso-Ramos C, Hasserjian RP, Orazi A
Virchows Arch 2023 Jan;482(1):69-83. Epub 2022 Dec 5 doi: 10.1007/s00428-022-03465-7. PMID: 36469102
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Shallis RM, Zeidan AM
Best Pract Res Clin Haematol 2020 Jun;33(2):101132. Epub 2019 Dec 6 doi: 10.1016/j.beha.2019.101132. PMID: 32460977

Therapy

Sanber K, Ye K, Tsai HL, Newman M, Webster JA, Gojo I, Ghiaur G, Prince GT, Gondek LP, Smith BD, Levis MJ, DeZern AE, Ambinder AJ, Dalton WB, Jain T
Leuk Lymphoma 2023 Apr;64(4):846-855. Epub 2023 Feb 6 doi: 10.1080/10428194.2023.2173523. PMID: 36744656
Zhang L, Wang SA
Int J Clin Exp Pathol 2014;7(7):3512-23. Epub 2014 Jun 15 PMID: 25120730Free PMC Article
Parikh SA, Tefferi A
Am J Hematol 2013 Nov;88(11):967-74. doi: 10.1002/ajh.23574. PMID: 23963888
Parikh SA, Tefferi A
Am J Hematol 2012 Jun;87(6):610-9. doi: 10.1002/ajh.23203. PMID: 22615103
Schroeder T, Kuendgen A, Kayser S, Kröger N, Braulke F, Platzbecker U, Klärner V, Zohren F, Haase D, Stadler M, Schlenk R, Czibere AG, Bruns I, Fenk R, Gattermann N, Haas R, Kobbe G, Germing U
Haematologica 2012 Feb;97(2):206-12. Epub 2011 Oct 11 doi: 10.3324/haematol.2011.049114. PMID: 21993688Free PMC Article

Prognosis

Fei F, Jariwala A, Pullarkat S, Loo E, Liu Y, Tizro P, Ali H, Otoukesh S, Amanam I, Artz A, Ally F, Telatar M, Nakamura R, Marcucci G, Afkhami M
Int J Mol Sci 2024 Sep 23;25(18) doi: 10.3390/ijms251810214. PMID: 39337700Free PMC Article
Hunter AM, Padron E
Best Pract Res Clin Haematol 2020 Sep;33(3):101195. Epub 2020 Jul 5 doi: 10.1016/j.beha.2020.101195. PMID: 33038984
Cross NCP
Clin Lymphoma Myeloma Leuk 2020 Sep;20 Suppl 1:S101-S102. doi: 10.1016/S2152-2650(20)30477-8. PMID: 32862848
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article

Clinical prediction guides

Mohamed A, Gao J, Chen YH, Abaza Y, Altman J, Jennings L, Vormittag-Nocito E, Sukhanova M, Lu X, Chen Q
Hum Pathol 2024 Jul;149:66-74. Epub 2024 Jun 13 doi: 10.1016/j.humpath.2024.06.008. PMID: 38879086
Lee MY, Jang S, Park CJ, Cho YU
Clin Lab 2022 Apr 1;68(4) doi: 10.7754/Clin.Lab.2021.210738. PMID: 35443589
Sangiorgio VFI, Orazi A, Arber DA
Best Pract Res Clin Haematol 2020 Jun;33(2):101139. Epub 2019 Dec 26 doi: 10.1016/j.beha.2019.101139. PMID: 32460987
Elena C, Gallì A, Such E, Meggendorfer M, Germing U, Rizzo E, Cervera J, Molteni E, Fasan A, Schuler E, Ambaglio I, Lopez-Pavia M, Zibellini S, Kuendgen A, Travaglino E, Sancho-Tello R, Catricalà S, Vicente AI, Haferlach T, Haferlach C, Sanz GF, Malcovati L, Cazzola M
Blood 2016 Sep 8;128(10):1408-17. Epub 2016 Jul 6 doi: 10.1182/blood-2016-05-714030. PMID: 27385790Free PMC Article
Vardiman J, Reichard K
Am J Clin Pathol 2015 Jul;144(1):29-43. doi: 10.1309/AJCP58RSMFRHLHHH. PMID: 26071460

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023

    Consumer resources

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