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    SLC2A3 solute carrier family 2 member 3 [ Homo sapiens (human) ]

    Gene ID: 6515, updated on 17-Jun-2024

    Summary

    Official Symbol
    SLC2A3provided by HGNC
    Official Full Name
    solute carrier family 2 member 3provided by HGNC
    Primary source
    HGNC:HGNC:11007
    See related
    Ensembl:ENSG00000059804 MIM:138170; AllianceGenome:HGNC:11007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUT3
    Summary
    Enables dehydroascorbic acid transmembrane transporter activity; glucose binding activity; and glucose transmembrane transporter activity. Involved in glucose import across plasma membrane and transport across blood-brain barrier. Is integral component of plasma membrane. Biomarker of Alzheimer's disease; acanthosis nigricans; diabetes mellitus; and type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bone marrow (RPKM 183.0), placenta (RPKM 54.5) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC2A3 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7919230..7936187, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7933413..7950362, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8071826..8088783, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 14 Neighboring gene myosin light chain 9 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8025026-8025706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8033506-8034091 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8034092-8034676 Neighboring gene Sharpr-MPRA regulatory region 8483 Neighboring gene Nanog homeobox pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:8057929-8058458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8060583-8061114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8062177-8062706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8065488-8066477 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:8086891-8087844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4205 Neighboring gene CRISPRi-validated cis-regulatory element chr12.441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5923 Neighboring gene CRISPRi-validated cis-regulatory element chr12.444 Neighboring gene CRISPRi-validated cis-regulatory element chr12.445 Neighboring gene uncharacterized LOC124902871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8120522-8121234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8121235-8121947 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8123373-8124086 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:8134452-8135651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:8145332-8146221 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8147335-8148256 Neighboring gene ribosomal protein S20 pseudogene 28

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90380

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 3
    Names
    GLUT-3
    glucose transporter type 3, brain
    solute carrier family 2 (facilitated glucose transporter), member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006931.3NP_008862.1  solute carrier family 2, facilitated glucose transporter member 3

      See identical proteins and their annotated locations for NP_008862.1

      Status: VALIDATED

      Source sequence(s)
      AC007536
      Consensus CDS
      CCDS8586.1
      UniProtKB/Swiss-Prot
      B2R606, D3DUU6, P11169, Q6I9U2, Q9UG15
      UniProtKB/TrEMBL
      B7Z966
      Related
      ENSP00000075120.7, ENST00000075120.12
      Conserved Domains (1) summary
      cd17431
      Location:12456
      MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      7919230..7936187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      7933413..7950362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)