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Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 [ Mus musculus (house mouse) ]

Gene ID: 20527, updated on 20-May-2022

Summary

Official Symbol
Slc2a3provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 3provided by MGI
Primary source
MGI:MGI:95757
See related
Ensembl:ENSMUSG00000003153 AllianceGenome:MGI:95757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut3; C78366; Glut-3; AA408729; AL023014; AL024341; AU040424
Summary
Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and glucose transmembrane transport. Located in acrosomal membrane and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; early conceptus; and reproductive system. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 213.3), placenta adult (RPKM 31.0) and 5 other tissues See more
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Genomic context

See Slc2a3 in Genome Data Viewer
Location:
6 F2; 6 57.82 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122704768..122779322, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122727809..122802363, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (122677827..122692763, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Nanog 5' regulatory region Neighboring gene predicted pseudogene 10224 Neighboring gene Nanog homeobox Neighboring gene Nanog +60 enhancer Neighboring gene uridine-cytidine kinase 1 pseudogene Neighboring gene forkhead box J2 Neighboring gene microRNA 7231 Neighboring gene complement component 3a receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Slc2a3 gene: The Slc2a3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in dehydroascorbic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 3
Names
glucose transporter type 3, brain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011401.4NP_035531.3  solute carrier family 2, facilitated glucose transporter member 3

    See identical proteins and their annotated locations for NP_035531.3

    Status: VALIDATED

    Source sequence(s)
    AK045328, AK164286, BC053911, BQ769655
    Consensus CDS
    CCDS20502.1
    UniProtKB/Swiss-Prot
    P32037
    UniProtKB/TrEMBL
    Q3TPL8, Q8BLF7
    Related
    ENSMUSP00000032476.5, ENSMUST00000032476.11
    Conserved Domains (2) summary
    cd06174
    Location:14437
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:13465
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    122704768..122779322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505822.4XP_006505885.1  solute carrier family 2, facilitated glucose transporter member 3 isoform X1

    See identical proteins and their annotated locations for XP_006505885.1

    Conserved Domains (1) summary
    cd17431
    Location:14458
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  2. XM_006505823.5XP_006505886.1  solute carrier family 2, facilitated glucose transporter member 3 isoform X1

    See identical proteins and their annotated locations for XP_006505886.1

    Conserved Domains (1) summary
    cd17431
    Location:14458
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  3. XM_011241268.3XP_011239570.1  solute carrier family 2, facilitated glucose transporter member 3 isoform X1

    See identical proteins and their annotated locations for XP_011239570.1

    Conserved Domains (1) summary
    cd17431
    Location:14458
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  4. XM_030255284.2XP_030111144.1  solute carrier family 2, facilitated glucose transporter member 3 isoform X1

    Conserved Domains (1) summary
    cd17431
    Location:14458
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  5. XM_036165983.1XP_036021876.1  solute carrier family 2, facilitated glucose transporter member 3 isoform X1

    Conserved Domains (1) summary
    cd17431
    Location:14458
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  6. XM_030255285.1XP_030111145.1  solute carrier family 2, facilitated glucose transporter member 3 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:1382
    MFS; Major Facilitator Superfamily