Format

Send to:

Choose Destination
    • Showing Current items.

    RIT1 Ras like without CAAX 1 [ Homo sapiens (human) ]

    Gene ID: 6016, updated on 19-Jul-2021

    Summary

    Official Symbol
    RIT1provided by HGNC
    Official Full Name
    Ras like without CAAX 1provided by HGNC
    Primary source
    HGNC:HGNC:10023
    See related
    Ensembl:ENSG00000143622 MIM:609591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NS8; RIT; RIBB; ROC1
    Summary
    This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.9), esophagus (RPKM 4.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RIT1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155897808..155911349, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155867599..155881140, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene gon-4 like Neighboring gene proteasome 26S subunit, non-ATPase 7 pseudogene Neighboring gene synaptotagmin 11 Neighboring gene small nucleolar RNA, H/ACA box 80E Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene small Cajal body-specific RNA 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
    GeneReviews: Not available
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Noonan syndrome 8
    MedGen: C3809233 OMIM: 615355 GeneReviews: Noonan Syndrome
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC125864, MGC125865

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    GTP-binding protein Rit1
    Names
    GTP-binding protein Roc1
    Ric-like, expressed in many tissues
    ras-like protein expressed in many tissues
    ras-like without CAAX protein 1
    NP_001243749.1
    NP_001243750.1
    NP_008843.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033885.1 RefSeqGene

      Range
      5054..18595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1372

    mRNA and Protein(s)

    1. NM_001256820.2NP_001243749.1  GTP-binding protein Rit1 isoform 3

      See identical proteins and their annotated locations for NP_001243749.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences. These difference cause translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK298768, AL139128, BU674989
      Consensus CDS
      CCDS58036.1
      UniProtKB/Swiss-Prot
      Q92963
      Related
      ENSP00000441950.1, ENST00000539040.5
      Conserved Domains (1) summary
      cl38936
      Location:1155
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001256821.2NP_001243750.1  GTP-binding protein Rit1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL139128, AL355388, BI916790, BQ918446, BU674989
      Consensus CDS
      CCDS58037.1
      UniProtKB/Swiss-Prot
      Q92963
      Related
      ENSP00000357305.3, ENST00000368322.7
      Conserved Domains (2) summary
      smart00010
      Location:37202
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04141
      Location:37208
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
    3. NM_006912.6NP_008843.1  GTP-binding protein Rit1 isoform 2

      See identical proteins and their annotated locations for NP_008843.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences. These difference cause translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AK298768, AL139128, AL355388, BC104186, BU674989
      Consensus CDS
      CCDS1123.1
      UniProtKB/Swiss-Prot
      Q92963
      Related
      ENSP00000357306.3, ENST00000368323.8
      Conserved Domains (1) summary
      cd04141
      Location:20191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      155897808..155911349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center