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Rit1 Ras-like without CAAX 1 [ Mus musculus (house mouse) ]

Gene ID: 19769, updated on 6-Nov-2022

Summary

Official Symbol
Rit1provided by MGI
Official Full Name
Ras-like without CAAX 1provided by MGI
Primary source
MGI:MGI:108053
See related
Ensembl:ENSMUSG00000028057 AllianceGenome:MGI:108053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rit; RIBB; ROC1
Summary
Enables GTP binding activity. Predicted to be involved in Ras protein signal transduction. Located in plasma membrane. Is expressed in Meckel's cartilage; bone; hip; and rib. Used to study Noonan syndrome 8. Human ortholog(s) of this gene implicated in Noonan syndrome 8. Orthologous to human RIT1 (Ras like without CAAX 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 14.8), heart adult (RPKM 14.6) and 28 other tissues See more
Orthologs
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Genomic context

See Rit1 in Genome Data Viewer
Location:
3; 3 F1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88624151..88638355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88716842..88731048)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 4 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene predicted gene, 25820 Neighboring gene synaptotagmin XI Neighboring gene gon-4-like pseudogene Neighboring gene RIKEN cDNA 1500004A13 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GTP-binding protein Rit1
Names
RAS-like protein expressed in many tissues
ras-like without CAAX protein 1
NP_001156782.1
NP_033095.1
XP_006501221.1
XP_006501223.1
XP_030108338.1
XP_036018857.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163310.2NP_001156782.1  GTP-binding protein Rit1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC134246
    Consensus CDS
    CCDS50952.1
    UniProtKB/TrEMBL
    E9Q672
    Related
    ENSMUSP00000130464.2, ENSMUST00000172252.2
    Conserved Domains (1) summary
    cl38936
    Location:1155
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001404021.1NP_001390950.1  GTP-binding protein Rit1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134246
    UniProtKB/Swiss-Prot
    P70426
  3. NM_001404022.1NP_001390951.1  GTP-binding protein Rit1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134246
    UniProtKB/Swiss-Prot
    P70426
  4. NM_001404029.1NP_001390958.1  GTP-binding protein Rit1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134246
    UniProtKB/TrEMBL
    E9Q672
  5. NM_001404030.1NP_001390959.1  GTP-binding protein Rit1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134246
    UniProtKB/TrEMBL
    E9Q672
  6. NM_001404031.1NP_001390960.1  GTP-binding protein Rit1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134246
    UniProtKB/TrEMBL
    E9Q672
  7. NM_001404033.1NP_001390962.1  GTP-binding protein Rit1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134246
  8. NM_001404034.1NP_001390963.1  GTP-binding protein Rit1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134246
  9. NM_001404035.1NP_001390964.1  GTP-binding protein Rit1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134246
  10. NM_001404036.1NP_001390965.1  GTP-binding protein Rit1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134246
  11. NM_009069.5NP_033095.1  GTP-binding protein Rit1 isoform 1

    See identical proteins and their annotated locations for NP_033095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC134246
    Consensus CDS
    CCDS17484.1
    UniProtKB/Swiss-Prot
    P70426
    Related
    ENSMUSP00000029692.9, ENSMUST00000029692.15
    Conserved Domains (1) summary
    cd04141
    Location:20191
    Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88624151..88638355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501158.5XP_006501221.1  GTP-binding protein Rit1 isoform X1

    Conserved Domains (1) summary
    cd04141
    Location:74245
    Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
  2. XM_006501160.5XP_006501223.1  GTP-binding protein Rit1 isoform X2

    UniProtKB/Swiss-Prot
    P70426
    Conserved Domains (1) summary
    cd04141
    Location:20191
    Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)
  3. XM_030252478.2XP_030108338.1  GTP-binding protein Rit1 isoform X3

    Conserved Domains (1) summary
    cl38936
    Location:1155
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_036162964.1XP_036018857.1  GTP-binding protein Rit1 isoform X3

    Conserved Domains (1) summary
    cl38936
    Location:1155
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_028056.1: Suppressed sequence

    Description
    NR_028056.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.