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    PRKCE protein kinase C epsilon [ Homo sapiens (human) ]

    Gene ID: 5581, updated on 2-May-2024

    Summary

    Official Symbol
    PRKCEprovided by HGNC
    Official Full Name
    protein kinase C epsilonprovided by HGNC
    Primary source
    HGNC:HGNC:9401
    See related
    Ensembl:ENSG00000171132 MIM:176975; AllianceGenome:HGNC:9401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKCE; nPKC-epsilon
    Summary
    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 4.7), lung (RPKM 2.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRKCE in Genome Data Viewer
    Location:
    2p21
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (45651279..46187990)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (45656327..46193193)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (45878814..46415129)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene S1 RNA binding domain 1 Neighboring gene RNA, 7SL, cytoplasmic 414, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15687 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:45867535-45867711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11438 Neighboring gene uncharacterized LOC102724965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11440 Neighboring gene Sharpr-MPRA regulatory region 4153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:45878872-45879492 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:45899906-45900117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15689 Neighboring gene PRKCE antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15690 Neighboring gene NANOG hESC enhancer GRCh37_chr2:45959936-45960443 Neighboring gene tRNA-Gln (anticodon TTG) 5-1 Neighboring gene Sharpr-MPRA regulatory region 1594 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:46013490-46014689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15692 Neighboring gene Sharpr-MPRA regulatory region 10855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:46050503-46051025 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:46051026-46051547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15694 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:46063209-46063734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15696 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:46121150-46121322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15698 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:46185885-46186435 Neighboring gene uncharacterized LOC124907761 Neighboring gene Sharpr-MPRA regulatory region 2946 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:46190573-46191772 Neighboring gene NANOG hESC enhancer GRCh37_chr2:46200583-46201132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15699 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:46234481-46235680 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:46242352-46242990 Neighboring gene ribosomal protein L26 pseudogene 15 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:46294453-46295652 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:46344077-46345276 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_58540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:46371061-46371560 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:46395156-46395343 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:46398401-46398983 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:46406387-46406887 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:46456039-46457023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15701 Neighboring gene uncharacterized LOC101926974 Neighboring gene uncharacterized LOC105374581 Neighboring gene Sharpr-MPRA regulatory region 5165 Neighboring gene Sharpr-MPRA regulatory region 3071 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:46518393-46518894 Neighboring gene ribosomal protein L36a pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11447 Neighboring gene Sharpr-MPRA regulatory region 14137 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:46587586-46588785 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:46611587-46612086 Neighboring gene endothelial PAS domain protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog
    Genome-wide association study of lung function decline in adults with and without asthma.
    EBI GWAS Catalog
    Genome-wide association study of suicide attempts in mood disorder patients.
    EBI GWAS Catalog
    Impact of ancestry and common genetic variants on QT interval in African Americans.
    EBI GWAS Catalog
    Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
    EBI GWAS Catalog
    Seventy-five genetic loci influencing the human red blood cell.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
    env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
    env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
    env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
    env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
    env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
    env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
    Nef nef HIV-1 Nef involves PRKCE in the induction of IL6 and CXCL8 (IL8) expression PubMed
    nef HIV-1 Nef downregulates the expression of PKC epsilon in human astrocytoma cells PubMed
    Tat tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
    tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
    tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
    tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
    matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
    retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
    reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125656, MGC125657

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin monomer binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables diacylglycerol-dependent serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ethanol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in TRAM-dependent toll-like receptor 4 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to prostaglandin E stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in locomotory exploration behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mucus secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of sodium ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cellular glucuronidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mucus secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell periphery ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein kinase C epsilon type
    NP_005391.1
    XP_005264485.1
    XP_005264488.1
    XP_006712113.1
    XP_011531273.1
    XP_011531277.1
    XP_011531280.1
    XP_011531282.1
    XP_011531283.1
    XP_011531284.1
    XP_011531285.1
    XP_016859977.1
    XP_016859979.1
    XP_016859981.1
    XP_047301050.1
    XP_047301051.1
    XP_047301052.1
    XP_047301053.1
    XP_047301054.1
    XP_047301055.1
    XP_047301056.1
    XP_054198947.1
    XP_054198948.1
    XP_054198949.1
    XP_054198950.1
    XP_054198951.1
    XP_054198952.1
    XP_054198953.1
    XP_054198954.1
    XP_054198955.1
    XP_054198956.1
    XP_054198957.1
    XP_054198958.1
    XP_054198959.1
    XP_054198960.1
    XP_054198961.1
    XP_054198962.1
    XP_054198963.1
    XP_054198964.1
    XP_054198965.1
    XP_054198966.1
    XP_054198967.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005400.3NP_005391.1  protein kinase C epsilon type

      See identical proteins and their annotated locations for NP_005391.1

      Status: REVIEWED

      Source sequence(s)
      AL832345, BC054052, CA424727, U51244, X65293
      Consensus CDS
      CCDS1824.1
      UniProtKB/Swiss-Prot
      B0LPH7, Q02156, Q32MQ3, Q53SL4, Q53SM5, Q9UE81
      UniProtKB/TrEMBL
      B2R9M7, L7RTI5
      Related
      ENSP00000306124.3, ENST00000306156.8
      Conserved Domains (4) summary
      cd04014
      Location:3135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd05591
      Location:412732
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      cd20835
      Location:161224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      45651279..46187990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264428.2XP_005264485.1  protein kinase C epsilon type isoform X1

      See identical proteins and their annotated locations for XP_005264485.1

      UniProtKB/Swiss-Prot
      B0LPH7, Q02156, Q32MQ3, Q53SL4, Q53SM5, Q9UE81
      UniProtKB/TrEMBL
      B2R9M7, L7RTI5
      Conserved Domains (4) summary
      cd04014
      Location:3135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd05591
      Location:412732
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      cd20835
      Location:161224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
    2. XM_047445100.1XP_047301056.1  protein kinase C epsilon type isoform X10

    3. XM_011532980.4XP_011531282.1  protein kinase C epsilon type isoform X4

      See identical proteins and their annotated locations for XP_011531282.1

      Conserved Domains (2) summary
      cd05591
      Location:262582
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:93143
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    4. XM_017004492.3XP_016859981.1  protein kinase C epsilon type isoform X7

    5. XM_005264431.5XP_005264488.1  protein kinase C epsilon type isoform X6

      Conserved Domains (3) summary
      cd04014
      Location:3135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      pfam00130
      Location:243295
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:412479
      PKc_like; Protein Kinases, catalytic domain
    6. XM_047445094.1XP_047301050.1  protein kinase C epsilon type isoform X2

    7. XM_011532971.4XP_011531273.1  protein kinase C epsilon type isoform X2

      See identical proteins and their annotated locations for XP_011531273.1

      UniProtKB/TrEMBL
      B2R9M7
      Conserved Domains (3) summary
      smart00220
      Location:312572
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:316636
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:147199
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    8. XM_017004490.3XP_016859979.1  protein kinase C epsilon type isoform X4

      Conserved Domains (2) summary
      cd05591
      Location:262582
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:93143
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    9. XM_047445096.1XP_047301052.1  protein kinase C epsilon type isoform X2

    10. XM_047445095.1XP_047301051.1  protein kinase C epsilon type isoform X2

    11. XM_011532975.4XP_011531277.1  protein kinase C epsilon type isoform X2

      See identical proteins and their annotated locations for XP_011531277.1

      UniProtKB/TrEMBL
      B2R9M7
      Conserved Domains (3) summary
      smart00220
      Location:312572
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:316636
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:147199
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    12. XM_047445098.1XP_047301054.1  protein kinase C epsilon type isoform X2

    13. XM_047445097.1XP_047301053.1  protein kinase C epsilon type isoform X2

    14. XM_017004488.3XP_016859977.1  protein kinase C epsilon type isoform X3

      UniProtKB/TrEMBL
      B2R9M7
      Conserved Domains (3) summary
      smart00220
      Location:294554
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:298618
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:129181
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    15. XM_011532978.3XP_011531280.1  protein kinase C epsilon type isoform X3

      See identical proteins and their annotated locations for XP_011531280.1

      UniProtKB/TrEMBL
      B2R9M7
      Conserved Domains (3) summary
      smart00220
      Location:294554
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:298618
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:129181
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    16. XM_047445099.1XP_047301055.1  protein kinase C epsilon type isoform X3

    17. XM_011532981.4XP_011531283.1  protein kinase C epsilon type isoform X4

      See identical proteins and their annotated locations for XP_011531283.1

      Conserved Domains (2) summary
      cd05591
      Location:262582
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:93143
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    18. XM_011532982.3XP_011531284.1  protein kinase C epsilon type isoform X5

      Conserved Domains (3) summary
      smart00220
      Location:168428
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:172492
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:355
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    19. XM_006712050.4XP_006712113.1  protein kinase C epsilon type isoform X8

      Conserved Domains (2) summary
      smart00220
      Location:131391
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:135455
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    20. XM_011532983.3XP_011531285.1  protein kinase C epsilon type isoform X9

      Conserved Domains (2) summary
      smart00220
      Location:107367
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:111431
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

    RNA

    1. XR_007078551.1 RNA Sequence

    2. XR_939695.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      45656327..46193193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342992.1XP_054198967.1  protein kinase C epsilon type isoform X10

    2. XM_054342986.1XP_054198961.1  protein kinase C epsilon type isoform X4

    3. XM_054342989.1XP_054198964.1  protein kinase C epsilon type isoform X7

    4. XM_054342988.1XP_054198963.1  protein kinase C epsilon type isoform X6

    5. XM_054342972.1XP_054198947.1  protein kinase C epsilon type isoform X2

    6. XM_054342973.1XP_054198948.1  protein kinase C epsilon type isoform X2

    7. XM_054342975.1XP_054198950.1  protein kinase C epsilon type isoform X2

    8. XM_054342984.1XP_054198959.1  protein kinase C epsilon type isoform X4

    9. XM_054342976.1XP_054198951.1  protein kinase C epsilon type isoform X2

    10. XM_054342978.1XP_054198953.1  protein kinase C epsilon type isoform X2

    11. XM_054342977.1XP_054198952.1  protein kinase C epsilon type isoform X2

    12. XM_054342974.1XP_054198949.1  protein kinase C epsilon type isoform X2

    13. XM_054342980.1XP_054198955.1  protein kinase C epsilon type isoform X3

    14. XM_054342982.1XP_054198957.1  protein kinase C epsilon type isoform X3

    15. XM_054342981.1XP_054198956.1  protein kinase C epsilon type isoform X3

    16. XM_054342979.1XP_054198954.1  protein kinase C epsilon type isoform X3

    17. XM_054342985.1XP_054198960.1  protein kinase C epsilon type isoform X4

    18. XM_054342983.1XP_054198958.1  protein kinase C epsilon type isoform X4

    19. XM_054342987.1XP_054198962.1  protein kinase C epsilon type isoform X5

    20. XM_054342990.1XP_054198965.1  protein kinase C epsilon type isoform X8

    21. XM_054342991.1XP_054198966.1  protein kinase C epsilon type isoform X9

    RNA

    1. XR_008486453.1 RNA Sequence

    2. XR_008486454.1 RNA Sequence