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Prkce protein kinase C, epsilon [ Mus musculus (house mouse) ]

Gene ID: 18754, updated on 17-Nov-2020

Summary

Official Symbol
Prkceprovided by MGI
Official Full Name
protein kinase C, epsilonprovided by MGI
Primary source
MGI:MGI:97599
See related
Ensembl:ENSMUSG00000045038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkc; Pkce; PKC[e; PKC[e]; R75156; PKCepsilon; 5830406C15Rik
Expression
Broad expression in frontal lobe adult (RPKM 22.3), cortex adult (RPKM 20.6) and 19 other tissues See more
Orthologs

Genomic context

See Prkce in Genome Data Viewer
Location:
17; 17 E4
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (86472631..86965347)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (86167785..86657919)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (86567125..87057259)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30117 Neighboring gene uncharacterized LOC118568290 Neighboring gene S1 RNA binding domain 1 Neighboring gene predicted gene 5817 Neighboring gene uncharacterized LOC118568291 Neighboring gene RIKEN cDNA 2010106C02 gene Neighboring gene predicted gene, 52296 Neighboring gene predicted gene, 30284 Neighboring gene predicted gene, 52297 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
actin monomer binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-independent protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ethanol binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor activator activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
TRAM-dependent toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to ethanol IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to prostaglandin E stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chemosensory behavior TAS
Traceable Author Statement
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory exploration behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-substrate adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular glucuronidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to morphine IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
T-tubule ISO
Inferred from Sequence Orthology
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C epsilon type
Names
nPKC-epsilon
NP_035234.1
XP_006523896.1
XP_017172817.1
XP_030105436.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011104.3NP_035234.1  protein kinase C epsilon type

    See identical proteins and their annotated locations for NP_035234.1

    Status: VALIDATED

    Source sequence(s)
    AC096777, AC154236, AC154351, AC154542, CT030001
    Consensus CDS
    CCDS29008.1
    UniProtKB/Swiss-Prot
    P16054
    Related
    ENSMUSP00000094874.2, ENSMUST00000097275.8
    Conserved Domains (4) summary
    cd04014
    Location:3135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    smart00220
    Location:408668
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:412732
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:243295
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    86472631..86965347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317328.3XP_017172817.1  protein kinase C epsilon type isoform X1

    Conserved Domains (4) summary
    cd04014
    Location:3135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    smart00220
    Location:408668
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00130
    Location:243295
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:412689
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030249576.2XP_030105436.1  protein kinase C epsilon type isoform X3

  3. XM_006523833.3XP_006523896.1  protein kinase C epsilon type isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:278538
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:282602
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:113165
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
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