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Prkce protein kinase C, epsilon [ Mus musculus (house mouse) ]

Gene ID: 18754, updated on 22-Jan-2023

Summary

Official Symbol
Prkceprovided by MGI
Official Full Name
protein kinase C, epsilonprovided by MGI
Primary source
MGI:MGI:97599
See related
Ensembl:ENSMUSG00000045038 AllianceGenome:MGI:97599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkce; PKC[e]; PKCepsilon; 5830406C15Rik
Summary
Enables several functions, including 14-3-3 protein binding activity; actin monomer binding activity; and calcium-independent protein kinase C activity. Involved in several processes, including TRAM-dependent toll-like receptor 4 signaling pathway; positive regulation of actin filament polymerization; and positive regulation of fibroblast migration. Acts upstream of or within several processes, including cellular response to alcohol; positive regulation of cell communication; and regulation of secretion. Located in several cellular components, including cytosol; mitochondrion; and perinuclear region of cytoplasm. Colocalizes with Golgi apparatus. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; neural retina; and salivary gland. Orthologous to human PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 22.3), cortex adult (RPKM 20.6) and 19 other tissues See more
Orthologs
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Genomic context

See Prkce in Genome Data Viewer
Location:
17; 17 E4
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (86472631..86965347)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (86167785..86657919)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30117 Neighboring gene S1 RNA binding domain 1 Neighboring gene predicted gene, 53966 Neighboring gene predicted gene 5817 Neighboring gene RIKEN cDNA 2010106C02 gene Neighboring gene predicted gene, 52296 Neighboring gene predicted gene, 53967 Neighboring gene predicted gene, 30284 Neighboring gene predicted gene, 52297 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actin monomer binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-independent protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ethanol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in TRAM-dependent toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell-substrate adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to ethanol IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to prostaglandin E stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chemosensory behavior TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory exploration behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular glucuronidation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to morphine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C epsilon type
Names
PCK epsilon
nPKC-epsilon
NP_035234.1
XP_006523896.1
XP_017172817.1
XP_030105436.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011104.3NP_035234.1  protein kinase C epsilon type

    See identical proteins and their annotated locations for NP_035234.1

    Status: VALIDATED

    Source sequence(s)
    AC096777, AC154236, AC154351, AC154542, CT030001
    Consensus CDS
    CCDS29008.1
    UniProtKB/Swiss-Prot
    P16054
    Related
    ENSMUSP00000094874.3, ENSMUST00000097275.9
    Conserved Domains (4) summary
    cd04014
    Location:3135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    smart00220
    Location:408668
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:412732
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:243295
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    86472631..86965347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317328.3XP_017172817.1  protein kinase C epsilon type isoform X1

    Conserved Domains (3) summary
    cd04014
    Location:3135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    pfam00130
    Location:243293
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:412689
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030249576.2XP_030105436.1  protein kinase C epsilon type isoform X3

    Conserved Domains (2) summary
    cd05591
    Location:262582
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:93143
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  3. XM_006523833.3XP_006523896.1  protein kinase C epsilon type isoform X2

    Conserved Domains (2) summary
    cd05591
    Location:282602
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:113163
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)