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PRKCE protein kinase C epsilon [ Homo sapiens (human) ]

Gene ID: 5581, updated on 6-May-2021

Summary

Official Symbol
PRKCEprovided by HGNC
Official Full Name
protein kinase C epsilonprovided by HGNC
Primary source
HGNC:HGNC:9401
See related
Ensembl:ENSG00000171132 MIM:176975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKCE; nPKC-epsilon
Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 4.7), lung (RPKM 2.1) and 23 other tissues See more
Orthologs
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Genomic context

See PRKCE in Genome Data Viewer
Location:
2p21
Exon count:
32
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (45651315..46187990)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (45878814..46415129)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene S1 RNA binding domain 1 Neighboring gene RNA, 7SL, cytoplasmic 414, pseudogene Neighboring gene uncharacterized LOC102724965 Neighboring gene Sharpr-MPRA regulatory region 4153 Neighboring gene PRKCE antisense RNA 1 Neighboring gene tRNA-Gln (anticodon TTG) 5-1 Neighboring gene Sharpr-MPRA regulatory region 2946 Neighboring gene ribosomal protein L26 pseudogene 15 Neighboring gene uncharacterized LOC101926974 Neighboring gene uncharacterized LOC105374581 Neighboring gene Sharpr-MPRA regulatory region 5165 Neighboring gene ribosomal protein L36a pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
GeneReviews: Not available
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
GeneReviews: Not available
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available
Genome-wide association study of lung function decline in adults with and without asthma.
GeneReviews: Not available
Genome-wide association study of suicide attempts in mood disorder patients.
GeneReviews: Not available
Impact of ancestry and common genetic variants on QT interval in African Americans.
GeneReviews: Not available
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
GeneReviews: Not available
Seventy-five genetic loci influencing the human red blood cell.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
Nef nef HIV-1 Nef involves PRKCE in the induction of IL6 and CXCL8 (IL8) expression PubMed
nef HIV-1 Nef downregulates the expression of PKC epsilon in human astrocytoma cells PubMed
Tat tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125656, MGC125657

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin monomer binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-independent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ethanol binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
involved_in TRAM-dependent toll-like receptor 4 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to prostaglandin E stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipopolysaccharide-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in locomotory exploration behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of sodium ion transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in platelet activation TAS
Traceable Author Statement
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cellular glucuronidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mucus secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to plasma membrane TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to morphine IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell periphery ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein kinase C epsilon type
NP_005391.1
XP_005264485.1
XP_005264488.1
XP_006712113.1
XP_011531273.1
XP_011531277.1
XP_011531280.1
XP_011531282.1
XP_011531283.1
XP_011531284.1
XP_011531285.1
XP_016859975.1
XP_016859976.1
XP_016859977.1
XP_016859978.1
XP_016859979.1
XP_016859980.1
XP_016859981.1
XP_024308759.1
XP_024308760.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005400.3NP_005391.1  protein kinase C epsilon type

    See identical proteins and their annotated locations for NP_005391.1

    Status: REVIEWED

    Source sequence(s)
    AL832345, BC054052, CA424727, U51244, X65293
    Consensus CDS
    CCDS1824.1
    UniProtKB/Swiss-Prot
    Q02156
    UniProtKB/TrEMBL
    L7RTI5
    Related
    ENSP00000306124.3, ENST00000306156.8
    Conserved Domains (4) summary
    cd04014
    Location:3135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    cd05591
    Location:412732
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    cd20835
    Location:161224
    C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
    cd20838
    Location:241295
    C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    45651315..46187990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004492.2XP_016859981.1  protein kinase C epsilon type isoform X7

  2. XM_005264431.4XP_005264488.1  protein kinase C epsilon type isoform X6

    Conserved Domains (3) summary
    cd04014
    Location:3135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    pfam00130
    Location:243295
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:412479
    PKc_like; Protein Kinases, catalytic domain
  3. XM_005264428.1XP_005264485.1  protein kinase C epsilon type isoform X1

    See identical proteins and their annotated locations for XP_005264485.1

    UniProtKB/Swiss-Prot
    Q02156
    UniProtKB/TrEMBL
    L7RTI5
    Conserved Domains (4) summary
    cd04014
    Location:3135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    cd05591
    Location:412732
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    cd20835
    Location:161224
    C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
    cd20838
    Location:241295
    C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
  4. XM_011532980.3XP_011531282.1  protein kinase C epsilon type isoform X4

    See identical proteins and their annotated locations for XP_011531282.1

    Conserved Domains (2) summary
    cd05591
    Location:262582
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:93143
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  5. XM_011532971.3XP_011531273.1  protein kinase C epsilon type isoform X2

    See identical proteins and their annotated locations for XP_011531273.1

    Conserved Domains (3) summary
    smart00220
    Location:312572
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:316636
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:147199
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  6. XM_017004490.2XP_016859979.1  protein kinase C epsilon type isoform X4

    Conserved Domains (2) summary
    cd05591
    Location:262582
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:93143
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  7. XM_024452992.1XP_024308760.1  protein kinase C epsilon type isoform X4

    Conserved Domains (2) summary
    cd05591
    Location:262582
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:93143
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  8. XM_017004489.2XP_016859978.1  protein kinase C epsilon type isoform X4

    Conserved Domains (2) summary
    cd05591
    Location:262582
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:93143
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  9. XM_024452991.1XP_024308759.1  protein kinase C epsilon type isoform X4

    Conserved Domains (2) summary
    cd05591
    Location:262582
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:93143
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  10. XM_011532975.3XP_011531277.1  protein kinase C epsilon type isoform X2

    See identical proteins and their annotated locations for XP_011531277.1

    Conserved Domains (3) summary
    smart00220
    Location:312572
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:316636
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:147199
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  11. XM_017004487.2XP_016859976.1  protein kinase C epsilon type isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:294554
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:298618
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:129181
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  12. XM_017004486.2XP_016859975.1  protein kinase C epsilon type isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:312572
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:316636
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:147199
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  13. XM_017004488.2XP_016859977.1  protein kinase C epsilon type isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:294554
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:298618
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:129181
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  14. XM_011532978.2XP_011531280.1  protein kinase C epsilon type isoform X3

    See identical proteins and their annotated locations for XP_011531280.1

    Conserved Domains (3) summary
    smart00220
    Location:294554
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:298618
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:129181
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  15. XM_017004491.2XP_016859980.1  protein kinase C epsilon type isoform X4

    Conserved Domains (2) summary
    cd05591
    Location:262582
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:93143
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  16. XM_011532981.3XP_011531283.1  protein kinase C epsilon type isoform X4

    See identical proteins and their annotated locations for XP_011531283.1

    Conserved Domains (2) summary
    cd05591
    Location:262582
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:93143
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  17. XM_011532982.2XP_011531284.1  protein kinase C epsilon type isoform X5

    Conserved Domains (3) summary
    smart00220
    Location:168428
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:172492
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:355
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  18. XM_006712050.3XP_006712113.1  protein kinase C epsilon type isoform X8

    Conserved Domains (2) summary
    smart00220
    Location:131391
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:135455
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
  19. XM_011532983.2XP_011531285.1  protein kinase C epsilon type isoform X9

    Conserved Domains (2) summary
    smart00220
    Location:107367
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:111431
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

RNA

  1. XR_939695.2 RNA Sequence

  2. XR_001738846.2 RNA Sequence

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