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    FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 2321, updated on 8-Jul-2021

    Summary

    Official Symbol
    FLT1provided by HGNC
    Official Full Name
    fms related receptor tyrosine kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:3763
    See related
    Ensembl:ENSG00000102755 MIM:165070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLT; FLT-1; VEGFR1; VEGFR-1
    Summary
    This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
    Expression
    Biased expression in placenta (RPKM 90.6), thyroid (RPKM 20.1) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FLT1 in Genome Data Viewer
    Location:
    13q12.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (28300346..28495128, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28874483..29069265, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 3 Neighboring gene RNA, U6 small nuclear 82, pseudogene Neighboring gene uncharacterized LOC105370135 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study of a coronary artery disease risk variant.
    GeneReviews: Not available
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates Flt-1 expression in human mesenchymal stem cells PubMed
    Nef nef HIV-1 Nef upregulates FLT1 in podocytes PubMed
    Tat tat HIV-1 Tat inhibits the differentiation of mesenchymal stem cells (MSCs) to endothelial cells by downregulating the expression of VEGF-induced endothelial markers such as Flt-1, KDR and vWF PubMed
    tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
    tat The mechanism of monocyte activation by HIV-1 Tat involves the binding of Tat to VEGFR-1/Flt-1 and activating signals through this receptor PubMed
    tat The soluble form of VEGFR-1 inhibits monocyte polarization and migration induced by HIV-1 Tat PubMed
    tat The biologic activities of HIV-1 Tat in human monocytes are, at least in part, elicited by Tat activation of VEGFR-1/Flt-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in embryonic morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hematopoietic progenitor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in hyaloid vascular plexus regression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of vascular endothelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phospholipase C activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in focal adhesion HDA PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vascular endothelial growth factor receptor 1
    Names
    fms related tyrosine kinase 1
    fms-like tyrosine kinase 1
    fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
    tyrosine-protein kinase FRT
    tyrosine-protein kinase receptor FLT
    vascular permeability factor receptor
    NP_001153392.1
    NP_001153502.1
    NP_001153503.1
    NP_002010.2
    XP_011533316.1
    XP_016875974.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012003.1 RefSeqGene

      Range
      5001..199783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_425

    mRNA and Protein(s)

    1. NM_001159920.2NP_001153392.1  vascular endothelial growth factor receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001153392.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as sFlt1 or sVEGFR-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 2) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.
      Source sequence(s)
      AL138712, AL139005
      Consensus CDS
      CCDS73556.1
      UniProtKB/Swiss-Prot
      P17948
      Related
      ENSP00000484039.1, ENST00000615840.4
      Conserved Domains (5) summary
      cd07702
      Location:353424
      Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
      smart00409
      Location:143219
      IG; Immunoglobulin
      smart00410
      Location:568640
      IG_like; Immunoglobulin like
      pfam13927
      Location:427539
      Ig_3; Immunoglobulin domain
      cl11960
      Location:245327
      Ig; Immunoglobulin domain
    2. NM_001160030.2NP_001153502.1  vascular endothelial growth factor receptor 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001153502.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 3) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.
      Source sequence(s)
      AK300392, AL138712, EU360600, EU368830
      Consensus CDS
      CCDS53860.1
      UniProtKB/Swiss-Prot
      P17948
      Related
      ENSP00000437631.1, ENST00000541932.5
      Conserved Domains (5) summary
      cd05742
      Location:245327
      Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
      cd07702
      Location:353424
      Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
      smart00408
      Location:569640
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:237328
      IG_like; Immunoglobulin like
      cl11960
      Location:671708
      Ig; Immunoglobulin domain
    3. NM_001160031.1NP_001153503.1  vascular endothelial growth factor receptor 1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001153503.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 4) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.
      Source sequence(s)
      DA844548, EU826561
      Consensus CDS
      CCDS53861.1
      UniProtKB/Swiss-Prot
      P17948
      Related
      ENSP00000442630.1, ENST00000539099.1
      Conserved Domains (4) summary
      cd05742
      Location:245327
      Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
      cd07702
      Location:353424
      Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
      smart00410
      Location:237328
      IG_like; Immunoglobulin like
      cl11960
      Location:439466
      Ig; Immunoglobulin domain
    4. NM_002019.4NP_002010.2  vascular endothelial growth factor receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_002010.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) the longest isoform (1). Isoform 1 is a transmembrane protein.
      Source sequence(s)
      AF063657, AL138712, BU151621, BX504049, DA851664
      Consensus CDS
      CCDS9330.1
      UniProtKB/Swiss-Prot
      P17948
      UniProtKB/TrEMBL
      L7RSL3
      Related
      ENSP00000282397.4, ENST00000282397.9
      Conserved Domains (8) summary
      cd05742
      Location:245327
      Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
      cd07702
      Location:353424
      Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
      smart00408
      Location:676738
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:568640
      IG; Immunoglobulin
      smart00410
      Location:237328
      IG_like; Immunoglobulin like
      pfam07679
      Location:661748
      I-set; Immunoglobulin I-set domain
      cd14207
      Location:8191157
      PTKc_VEGFR1; Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
      pfam07714
      Location:8271154
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      28300346..28495128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020485.1XP_016875974.1  vascular endothelial growth factor receptor 1 isoform X1

    2. XM_011535014.1XP_011533316.1  vascular endothelial growth factor receptor 1 isoform X2

      Conserved Domains (5) summary
      cd05742
      Location:245327
      Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
      cd07702
      Location:353424
      Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
      smart00408
      Location:569640
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:237328
      IG_like; Immunoglobulin like
      cl11960
      Location:660720
      Ig; Immunoglobulin domain
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