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Flt1 FMS-like tyrosine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 14254, updated on 28-Dec-2022

Summary

Official Symbol
Flt1provided by MGI
Official Full Name
FMS-like tyrosine kinase 1provided by MGI
Primary source
MGI:MGI:95558
See related
Ensembl:ENSMUSG00000029648 AllianceGenome:MGI:95558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Flt-1; sFlt1; VEGFR1; VEGFR-1
Summary
Enables identical protein binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including blood vessel morphogenesis; embryonic morphogenesis; and hyaloid vascular plexus regression. Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 35.7), lung adult (RPKM 11.8) and 11 other tissues See more
Orthologs
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Genomic context

See Flt1 in Genome Data Viewer
Location:
5 G3; 5 87.01 cM
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147498414..147663419, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147561604..147726438, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 5, ERATO Doi 605, expressed Neighboring gene PAN3 poly(A) specific ribonuclease subunit Neighboring gene predicted gene, 35383 Neighboring gene predicted gene, 35541 Neighboring gene predicted gene, 35592

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables placental growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables vascular endothelial growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyaloid vascular plexus regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor-1 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
vascular endothelial growth factor receptor 1
Names
embryonic receptor kinase 2
tyrosine-protein kinase receptor FLT
vascular permeability factor receptor
NP_001350064.1
NP_034358.2
XP_006504864.1
XP_006504865.1
XP_006504866.1
XP_011239302.1
XP_036020680.1
XP_036020681.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363135.1NP_001350064.1  vascular endothelial growth factor receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131730, AK013236, AK167497, BP763953
    Consensus CDS
    CCDS90022.1
    UniProtKB/TrEMBL
    O55095
    Related
    ENSMUSP00000106158.2, ENSMUST00000110529.6
    Conserved Domains (4) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:144220
    IG; Immunoglobulin
    pfam13927
    Location:428540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  2. NM_010228.4NP_034358.2  vascular endothelial growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034358.2

    Status: VALIDATED

    Source sequence(s)
    AC122299, AC131730
    Consensus CDS
    CCDS19879.1
    UniProtKB/Swiss-Prot
    P35969
    UniProtKB/TrEMBL
    A0A0R4J0A4
    Related
    ENSMUSP00000031653.6, ENSMUST00000031653.12
    Conserved Domains (8) summary
    cd00096
    Location:452550
    Ig; Immunoglobulin domain
    smart00408
    Location:677739
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:570641
    IG; Immunoglobulin
    smart00410
    Location:238329
    IG_like; Immunoglobulin like
    pfam07679
    Location:662749
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:8281154
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
    cl21453
    Location:8201157
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    147498414..147663419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164787.1XP_036020680.1  vascular endothelial growth factor receptor 1 isoform X2

    Conserved Domains (4) summary
    smart00408
    Location:475
    IGc2; Immunoglobulin C-2 Type
    pfam07679
    Location:96183
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:114117
    Ig; Ig strand B [structural motif]
    cl21453
    Location:254591
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011241000.4XP_011239302.1  vascular endothelial growth factor receptor 1 isoform X3

    Conserved Domains (5) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:144220
    IG_like; Immunoglobulin like
    pfam07679
    Location:662749
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:429540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  3. XM_006504801.5XP_006504864.1  vascular endothelial growth factor receptor 1 isoform X1

    Conserved Domains (4) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:144220
    IG; Immunoglobulin
    pfam13927
    Location:429540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  4. XM_006504802.5XP_006504865.1  vascular endothelial growth factor receptor 1 isoform X4

    Conserved Domains (4) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:144220
    IG_like; Immunoglobulin like
    pfam13927
    Location:429540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  5. XM_006504803.5XP_006504866.1  vascular endothelial growth factor receptor 1 isoform X5

    Conserved Domains (4) summary
    smart00408
    Location:570641
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:144220
    IG; Immunoglobulin
    pfam13927
    Location:429540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354425
    Ig; Immunoglobulin domain
  6. XM_036164788.1XP_036020681.1  vascular endothelial growth factor receptor 1 isoform X6

    Conserved Domains (4) summary
    smart00410
    Location:144220
    IG_like; Immunoglobulin like
    pfam13927
    Location:428468
    Ig_3; Immunoglobulin domain
    cd00096
    Location:334338
    Ig; Ig strand A [structural motif]
    cl11960
    Location:334425
    Ig; Immunoglobulin domain

RNA

  1. XR_004942438.1 RNA Sequence