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FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) ]

Gene ID: 2321, updated on 22-Nov-2020

Summary

Official Symbol
FLT1provided by HGNC
Official Full Name
fms related receptor tyrosine kinase 1provided by HGNC
Primary source
HGNC:HGNC:3763
See related
Ensembl:ENSG00000102755 MIM:165070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLT; FLT-1; VEGFR1; VEGFR-1
Summary
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
Expression
Biased expression in placenta (RPKM 90.6), thyroid (RPKM 20.1) and 8 other tissues See more
Orthologs

Genomic context

See FLT1 in Genome Data Viewer
Location:
13q12.3
Exon count:
33
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (28300346..28495128, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28874483..29069265, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 3 Neighboring gene RNA, U6 small nuclear 82, pseudogene Neighboring gene uncharacterized LOC105370135 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of a coronary artery disease risk variant.
GeneReviews: Not available
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates Flt-1 expression in human mesenchymal stem cells PubMed
Nef nef HIV-1 Nef upregulates FLT1 in podocytes PubMed
Tat tat HIV-1 Tat inhibits the differentiation of mesenchymal stem cells (MSCs) to endothelial cells by downregulating the expression of VEGF-induced endothelial markers such as Flt-1, KDR and vWF PubMed
tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
tat The mechanism of monocyte activation by HIV-1 Tat involves the binding of Tat to VEGFR-1/Flt-1 and activating signals through this receptor PubMed
tat The soluble form of VEGFR-1 inhibits monocyte polarization and migration induced by HIV-1 Tat PubMed
tat The biologic activities of HIV-1 Tat in human monocytes are, at least in part, elicited by Tat activation of VEGFR-1/Flt-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
placental growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
embryonic morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hyaloid vascular plexus regression ISS
Inferred from Sequence or Structural Similarity
more info
 
monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
vascular endothelial growth factor receptor-1 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
focal adhesion HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vascular endothelial growth factor receptor 1
Names
fms related tyrosine kinase 1
fms-like tyrosine kinase 1
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
tyrosine-protein kinase FRT
tyrosine-protein kinase receptor FLT
vascular permeability factor receptor
NP_001153392.1
NP_001153502.1
NP_001153503.1
NP_002010.2
XP_011533316.1
XP_016875974.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012003.1 RefSeqGene

    Range
    5001..199783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159920.2NP_001153392.1  vascular endothelial growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001153392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as sFlt1 or sVEGFR-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 2) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.
    Source sequence(s)
    AL138712, AL139005
    Consensus CDS
    CCDS73556.1
    UniProtKB/Swiss-Prot
    P17948
    Related
    ENSP00000484039.1, ENST00000615840.4
    Conserved Domains (5) summary
    cd07702
    Location:353424
    Ig_VEGFR-1; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00409
    Location:143219
    IG; Immunoglobulin
    smart00410
    Location:568640
    IG_like; Immunoglobulin like
    pfam13927
    Location:427539
    Ig_3; Immunoglobulin domain
    cl11960
    Location:245327
    Ig; Immunoglobulin domain
  2. NM_001160030.2NP_001153502.1  vascular endothelial growth factor receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001153502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 3) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.
    Source sequence(s)
    AK300392, AL138712, EU360600, EU368830
    Consensus CDS
    CCDS53860.1
    UniProtKB/Swiss-Prot
    P17948
    Related
    ENSP00000437631.1, ENST00000541932.5
    Conserved Domains (5) summary
    cd05742
    Location:245327
    Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
    cd07702
    Location:353424
    Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00408
    Location:569640
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    cl11960
    Location:671708
    Ig; Immunoglobulin domain
  3. NM_001160031.1NP_001153503.1  vascular endothelial growth factor receptor 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001153503.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 4) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.
    Source sequence(s)
    DA844548, EU826561
    Consensus CDS
    CCDS53861.1
    UniProtKB/Swiss-Prot
    P17948
    Related
    ENSP00000442630.1, ENST00000539099.1
    Conserved Domains (4) summary
    cd05742
    Location:245327
    Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
    cd07702
    Location:353424
    Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    cl11960
    Location:439466
    Ig; Immunoglobulin domain
  4. NM_002019.4NP_002010.2  vascular endothelial growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002010.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) the longest isoform (1). Isoform 1 is a transmembrane protein.
    Source sequence(s)
    AF063657, AL138712, BU151621, BX504049, DA851664
    Consensus CDS
    CCDS9330.1
    UniProtKB/Swiss-Prot
    P17948
    UniProtKB/TrEMBL
    L7RSL3
    Related
    ENSP00000282397.4, ENST00000282397.9
    Conserved Domains (8) summary
    cd05742
    Location:245327
    Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
    cd07702
    Location:353424
    Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00408
    Location:676738
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:568640
    IG; Immunoglobulin
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    pfam07679
    Location:661748
    I-set; Immunoglobulin I-set domain
    cd14207
    Location:8191157
    PTKc_VEGFR1; Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors
    pfam07714
    Location:8271154
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    28300346..28495128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020485.1XP_016875974.1  vascular endothelial growth factor receptor 1 isoform X1

  2. XM_011535014.1XP_011533316.1  vascular endothelial growth factor receptor 1 isoform X2

    Conserved Domains (5) summary
    cd05742
    Location:245327
    Ig1_VEGFR_like; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins
    cd07702
    Location:353424
    Ig2_VEGFR-1; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1)
    smart00408
    Location:569640
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    cl11960
    Location:660720
    Ig; Immunoglobulin domain
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