Format

Send to:

Choose Destination

CDK11B cyclin dependent kinase 11B [ Homo sapiens (human) ]

Gene ID: 984, updated on 3-Mar-2019

Summary

Official Symbol
CDK11Bprovided by HGNC
Official Full Name
cyclin dependent kinase 11Bprovided by HGNC
Primary source
HGNC:HGNC:1729
See related
Ensembl:ENSG00000248333 MIM:176873
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p58; PK58; CDK11; CLK-1; CDC2L1; PITSLREA; p58CLK-1; CDK11-p46; CDK11-p58; p58CDC2L1; CDK11-p110
Summary
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in testis (RPKM 20.1), bone marrow (RPKM 18.4) and 25 other tissues See more
Orthologs

Genomic context

See CDK11B in Genome Data Viewer
Location:
1p36.33
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1635226..1659619, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1571100..1590473, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378586 Neighboring gene fibronectin type III domain containing 10 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene matrix metallopeptidase 23B Neighboring gene solute carrier family 35 member E2B Neighboring gene ribosomal protein S7 pseudogene Neighboring gene matrix metallopeptidase 23A (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat CDK11 depletion reduces protein expression of CDK9 and HEXIM1 and Tat transactivation of HIV-1 provirus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ59152

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of mRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 11B
Names
CDC-related protein kinase p58
PITSLRE serine/threonine-protein kinase CDC2L1
cell division cycle 2-like 1 (PITSLRE proteins)
cell division protein kinase 11B
galactosyltransferase-associated protein kinase p58/GTA
p58 CLK-1
NP_001278274.1
NP_001778.2
NP_277021.2
NP_277022.1
NP_277024.2
NP_277025.1
XP_006711128.1
XP_011540792.1
XP_011540793.1
XP_011540794.1
XP_011540795.1
XP_011540796.1
XP_011540797.1
XP_016858414.1
XP_016858415.1
XP_016858416.1
XP_016858417.1
XP_024306942.1
XP_024306952.1
XP_024306958.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291345.1NP_001278274.1  cyclin-dependent kinase 11B isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses two alternate splice sites in the central coding region, compared to variant 1. The encoded isoform (10) is shorter, compared to isoform 1.
    Source sequence(s)
    AA778148, AK000081, BC140714, DB516340, DC295949, DC362247, DC393302
    UniProtKB/TrEMBL
    B7ZVY7
    Related
    ENSP00000485705.1, ENST00000626918.2
    Conserved Domains (2) summary
    cd07843
    Location:409700
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:412702
    PLN00009; cyclin-dependent kinase A; Provisional
  2. NM_001787.2NP_001778.2  cyclin-dependent kinase 11B isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA778148, AK000081, BC140714, DB516340, DC362247, DC393302
    Consensus CDS
    CCDS72683.1
    UniProtKB/TrEMBL
    B7ZVY7, J3QR44
    Related
    ENSP00000464036.2, ENST00000407249.7
    Conserved Domains (1) summary
    cd07843
    Location:432723
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  3. NM_033486.2NP_277021.2  cyclin-dependent kinase 11B isoform 2

    See identical proteins and their annotated locations for NP_277021.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AA778148, AK000081, BC140714, DB516340, DC362247, DC393302
    Consensus CDS
    CCDS72684.1
    UniProtKB/TrEMBL
    B7ZVY7
    Related
    ENSP00000463048.2, ENST00000341832.10
    Conserved Domains (2) summary
    cd07843
    Location:419710
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:422712
    PLN00009; cyclin-dependent kinase A; Provisional
  4. NM_033487.2NP_277022.1  cyclin-dependent kinase 11B isoform 3

    See identical proteins and their annotated locations for NP_277022.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA778148, AK000081, BC140714, DB516340, DC362247, DC393302
    UniProtKB/Swiss-Prot
    P21127
    UniProtKB/TrEMBL
    B7ZVY7
    Conserved Domains (2) summary
    cd07843
    Location:163454
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:166456
    PLN00009; cyclin-dependent kinase A; Provisional
  5. NM_033489.2NP_277024.2  cyclin-dependent kinase 11B isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and 5' coding region, and uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA778148, AK000081, AK295607, BC140714, DB516340, DC362247, DC393302
    Consensus CDS
    CCDS72682.1
    UniProtKB/TrEMBL
    B4DII1, B7ZVY7, J3QR29
    Related
    ENSP00000464016.2, ENST00000340677.9
    Conserved Domains (2) summary
    cd07843
    Location:385676
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:388678
    PLN00009; cyclin-dependent kinase A; Provisional
  6. NM_033490.2NP_277025.1  cyclin-dependent kinase 11B isoform 6

    See identical proteins and their annotated locations for NP_277025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR, uses a downstream start codon, and uses an alternate splice site in its 5' coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    AA778148, AK000081, BC140714, DB516340, DC362247, DC393302
    UniProtKB/Swiss-Prot
    P21127
    UniProtKB/TrEMBL
    B7ZVY7
    Conserved Domains (2) summary
    cd07843
    Location:202493
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:205495
    PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    1635226..1659619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002927.2XP_016858416.1  cyclin-dependent kinase 11B isoform X6

    Conserved Domains (1) summary
    cd07843
    Location:407698
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  2. XM_006711065.4XP_006711128.1  cyclin-dependent kinase 11B isoform X4

    Conserved Domains (2) summary
    cd07843
    Location:422713
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:425715
    PLN00009; cyclin-dependent kinase A; Provisional
  3. XM_017002926.2XP_016858415.1  cyclin-dependent kinase 11B isoform X5

  4. XM_011542493.3XP_011540795.1  cyclin-dependent kinase 11B isoform X2

    Conserved Domains (2) summary
    cd07843
    Location:431722
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:434724
    PLN00009; cyclin-dependent kinase A; Provisional
  5. XM_024451190.1XP_024306958.1  cyclin-dependent kinase 11B isoform X10

    Conserved Domains (1) summary
    cd07843
    Location:34325
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  6. XM_017002925.2XP_016858414.1  cyclin-dependent kinase 11B isoform X3

  7. XM_011542490.3XP_011540792.1  cyclin-dependent kinase 11B isoform X1

    See identical proteins and their annotated locations for XP_011540792.1

    Conserved Domains (2) summary
    cd07843
    Location:441732
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:444734
    PLN00009; cyclin-dependent kinase A; Provisional
  8. XM_011542495.3XP_011540797.1  cyclin-dependent kinase 11B isoform X8

    Conserved Domains (2) summary
    cd07843
    Location:397688
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:400690
    PLN00009; cyclin-dependent kinase A; Provisional
  9. XM_017002928.2XP_016858417.1  cyclin-dependent kinase 11B isoform X7

  10. XM_011542494.3XP_011540796.1  cyclin-dependent kinase 11B isoform X6

    Conserved Domains (1) summary
    cd07843
    Location:407698
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  11. XM_024451174.1XP_024306942.1  cyclin-dependent kinase 11B isoform X6

    Conserved Domains (1) summary
    cd07843
    Location:407698
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  12. XM_011542492.2XP_011540794.1  cyclin-dependent kinase 11B isoform X1

    See identical proteins and their annotated locations for XP_011540794.1

    Conserved Domains (2) summary
    cd07843
    Location:441732
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:444734
    PLN00009; cyclin-dependent kinase A; Provisional
  13. XM_011542491.2XP_011540793.1  cyclin-dependent kinase 11B isoform X1

    See identical proteins and their annotated locations for XP_011540793.1

    Conserved Domains (2) summary
    cd07843
    Location:441732
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:444734
    PLN00009; cyclin-dependent kinase A; Provisional
  14. XM_024451184.1XP_024306952.1  cyclin-dependent kinase 11B isoform X9

    Conserved Domains (1) summary
    cd07843
    Location:215506
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

RNA

  1. XR_002958171.1 RNA Sequence

  2. XR_002958173.1 RNA Sequence

  3. XR_002958174.1 RNA Sequence

  4. XR_002958172.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033488.1: Suppressed sequence

    Description
    NM_033488.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_033492.1: Suppressed sequence

    Description
    NM_033492.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_033493.1: Suppressed sequence

    Description
    NM_033493.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center