Conserved Protein Domain Family
STKc_CDC2L1

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cd07843: STKc_CDC2L1 
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 173741
View PSSM: cd07843
Aligned: 29 rows
Threshold Bit Score: 482.109
Threshold Setting Gi: 85109223
Created: 31-Jul-2006
Updated: 2-Mar-2014
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     ####    #            # #                  #              #         
gi 34978359  432 CRSVE-EFQCLNRIEEGTYGVVYRAKDKKTdEIVALKRLKMEKEK--EGFPITSLREINTILKAq-HPNIVTVREIVVGs 507
gi 575365    368 CRNVK-NYKKLNKISEGTYGAVYRAQNKRTkKIVALKKLKNFSSMhnEGFAMTSLREINILLQLq-HDNILSIKEVVFGk 445
gi 3006192    68 CNSID-DYEILEKIEEGSYGIVYRGLDKSTnTLVALKKIKFDPNG--IGFPITSLREIESLSSIr-HDNIVELEKVVVGk 143
gi 239897287  60 CRSVD-NYEKLNRIDEGTYGVVYRAREKTTgKICALKQVKLREQDdsSGFPLTALREVDTLLRLr-HENIITVSEVAVGa 137
gi 4325070   218 CRRVE-IFKRLNKISEGTYGAVFRAMNRTTgEIVALKQIKYHNKLwsEGFPVTSLREISIMLELq-HPNVLDVQEVVVGt 295
gi 118348498  80 CDSVD-NYQKLNKIHEGVYGVVYRAVDKLTgEIIAIKKTKIDRKKekEGFPITSIREFNILMALr-HENIVAVKRVVMGt 157
gi 50260614  156 CRSVY-NYTRLNHIEEGTYGVVFRARCNDTgEIYALKKLKLDEEK--QGFPITSLREVMALMISggHENVVGIREIVVGd 232
gi 164656455  45 CGSVS-SYEILNRIEEGSYGVVSRARHKQTgEIVALKQLKFEKEG--LGFPITSLREVQVLMEAr-HPHIVELKEMVVGd 120
gi 223996823   1 CRSVYdSYERISHLDEGTYGVVWKAKDNSTgEIVALKQIKFDSEMtkEGFPISALREIGVLLSLs-HECIVTVREMVVGs 79
gi 84996961   86 CRDVE-CFKCLNKISEGTYGTVYRALEIKTgKIVALKHIKYHDVQwkEGFPLTYLREISILLQLn-HPNILSVKEIVTNk 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ####  # ##                                       # # ## #          #  # 
gi 34978359  508 nmDKIYIVMNYVEHDLKSLMETMKq---pFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHaGILKVGDFGLA 584
gi 575365    446 hlNDIYLVMEYIEHELKMILDNKSp---sFTISELKCLLKQLLSGINYLHRNWVMHRDLKPTNLLYSNkGILKICDFGMA 522
gi 3006192   144 dlKDVYLVMEFMEHDLKTLLDNMPe---dFLQSEVKTLMLQLLAATAFMHHHWYLHRDLKPSNLLMNNtGEIKLADFGLA 220
gi 239897287 138 rsTQIYMVMEYMEHELKDLLEHLTpd-egLRQAEVKSLVVQLLSGVAYMHERWIIHRDLKTSNLLFNNrGVLKICDFGLA 216
gi 4325070   296 gqHQVFMVMEYIEHEVKTLLDEKPe----FSTAERKCLLYQLLEALAYMHANFVFHRDLKPSNLLYSNrGVLKVADFGMA 371
gi 118348498 158 dlDSIYMIMEYMEHELKDVIENHHd---eFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNkGQLKICDFGLG 234
gi 50260614  233 tlNQVFIVMPFIEHDLKTLLADMPh---pFLQSEVKTIMLQLLSAVAHCHANWILHRDLKTSNLLMNNrGQIKVADFGLA 309
gi 164656455 121 tiNHVYLVMEFVEHDLKTLLTTMRt---pFLLSEIKTLMKQLLSAVALMHSRWIVHRDLKASNLLLSNrGQIKIADFGLA 197
gi 223996823  80 thDKVFMVMECMEMDLQAAMKHGPgtsspFAQSEVKFMMHQLLSAMAHVHERWFLHRDVKTSNVLVHKsGRIALCDFGLA 159
gi 84996961  164 kqDQFYMVMEYVEHELKTLLEENRp---nFTLSERKCLLKQLLDGINYLHQNWVMHRDLKTTNILYNNsGLVKICDFGMA 240
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    # #### #                                       ##                   
gi 34978359  585 REYGSPl--KAYTPVVVTLWYRAPELLLGAKE--YSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEK 660
gi 575365    523 RKFGHVt-nHNFTKNVVTLWYRAPELLLGEQC--YTNKIDIWSAGCIFAEMILKKPLFVGENEIDQLFKILCLLGLPDKE 599
gi 3006192   221 RPVSEPk--SSLTRLVVTLWYRAPELLLGAPS--YGKEIDMWSIGCIFAEMITRTPLFSGKSELDQLYKIFNLLGYPTRE 296
gi 239897287 217 RQYSEPi--DTMTRKVVTLWYRAPELLLGPADykYTTAIDMWSCGCIVGEIIRRDPLFAEASEVDVLEKILDLVGTPNVN 294
gi 4325070   372 RKFGFPlhnRVFTKNVVTLWYRPPEILLGEGT--YDAACDVWAVGAIFGEFLRKKPLFAGHGELDTLNKIFKLCGTPTDS 449
gi 118348498 235 RRWQGN---KPYTLNVVTMWYRAPEVLLGQDK--YTTALDMWSVGCIFGELITKDQLFKGKNETNQIECIFNAMGGPTER 309
gi 50260614  310 RKFGDPl--GEMTQLVVTLWYRSPELLLGGKE--YTTAVDIWSIGCIFAELMQGEPLFPGRGEIDQINRIFQLLGRPNDE 385
gi 164656455 198 RLFGDPl--TDMTSLVVTLWYRAPELLLGKKR--YDTAIDMWSVGCIFAELLMKEPLFPGKNETDQLSRILRLLGSPTET 273
gi 223996823 160 RKYEVPa--KNMTQMVVTLWYRAPEVLFGESK--YGAEIDLWSIGCIFGELLTKDAMLKGTGELDQIQKIFKLVGTPNED 235
gi 84996961  241 RKFGVPi--RKYTHNVVTHWYRAPELFLGEPY--YTEKTDVWSIGCIFAELILSRPLFMGTNDADTLDKIFRLCGSPNEE 316
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 34978359  661 I-WPGYsELPAVKk------MTFSEHPYNNL--RKRFGAl-----------lSDQGFDLMNKFLTYFPGRRISAEDGLKH 720
gi 575365    600 S-YPEFyEYSFISknkelfkKKKIKMNVNNI--RSHFPNianqf---sglylSDNGLDLLQKMLHYNPQCRISAQEALNH 673
gi 3006192   297 E-WPQYfLLPYANk-----iKHPTVPTHSKI--RTSIPNl------------TGNAYDLLNRLLSLNPAKRISAKEALEH 356
gi 239897287 295 RkWPEFrSYVTAKg-----lKIRTRQPNWRSa-AIGFPQagivss--vscplTHVGLDLMQGLLDLNPVTRLSAKAALNH 366
gi 4325070   450 S-WPEFhSLPHIKn-----kKFFNSPPQCQPswREVFPPpskhlamgssgvlTDLGLDLLQKLLELNPAKRITAAEALQH 523
gi 118348498 310 S-WPGWtEFKHSKl-----fKDRNYPSECTL--NEKIGNr-----------iSQTGYKLLCQMLTLNPKERITATKALQD 370
gi 50260614  386 S-WPGYsTLPLVQk------INPIGPMFSTL--RQKFKHl------------TYEGHNLLSSLLCYDPERRITAEEALKH 444
gi 164656455 274 T-WPEFaSLLKSR-------FKHTTHVRSQL--RHHFRLf------------SDATVDLLQSFLCYDSSKRISAHDALQH 331
gi 223996823 236 N-WPEFsSLPSAGt------FKWKNKDGSEL--GRRFQVnsfsat--gqsylDTSGFDLLGKLLALNPRQRISAEDALKH 304
gi 84996961  317 N-WPGFsKLPGIVs------NKFQIHKYNPSf-ENVFKVgimggmvhgstcmTELGLDLLKKMLNIDPNQRISAKDALNH 388

                 ...
Feature 1           
gi 34978359  721 EYF 723
gi 575365    674 PYF 676
gi 3006192   357 PYF 359
gi 239897287 367 PWL 369
gi 4325070   524 EYF 526
gi 118348498 371 PWF 373
gi 50260614  445 PYF 447
gi 164656455 332 AYF 334
gi 223996823 305 PYF 307
gi 84996961  389 PYI 391

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