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Cdk11b cyclin-dependent kinase 11B [ Mus musculus (house mouse) ]

Gene ID: 12537, updated on 8-Dec-2022

Summary

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Official Symbol
Cdk11bprovided by MGI
Official Full Name
cyclin-dependent kinase 11Bprovided by MGI
Primary source
MGI:MGI:88353
See related
Ensembl:ENSMUSG00000029062 AllianceGenome:MGI:88353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p58; Cdk11; Cdc11b; Cdc2l1; Cdc2l2; CDK11-p46; CDK11-p58; CDK11-p110
Summary
Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Located in nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; early embryo; and integumental system. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.0), large intestine adult (RPKM 15.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cdk11b in Genome Data Viewer
Location:
4 E2; 4 86.73 cM
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155709293..155734392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155624841..155649935)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene NAD kinase Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene matrix metallopeptidase 23 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene fibronectin type III domain containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CDK11p58 Promotes Microglia Activation via Inducing Cyclin D3 Nuclear Localization. Shen B, et al. Inflammation, 2017 Apr. PMID 28101846
  2. A cyclin-dependent kinase homologue, p130PITSLRE is a phosphotyrosine-independent SH2 ligand. Malek SN, et al. J Biol Chem, 1994 Dec 30. PMID 7528743
  3. Regulated expression of a cell division control-related protein kinase during development. Kidd VJ, et al. Cell Growth Differ, 1991 Feb. PMID 2069872
  4. CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model. Sala E, et al. Front Immunol, 2021. PMID 33664748, Free PMC Article
  5. Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice. Chandramouli A, et al. Carcinogenesis, 2007 Sep. PMID 17389615

See all (41) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model.
    Title: CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model.
  2. suggested that CDK11p58 acted to regulate microglia activation through CDK11p58 and cyclin D3 interaction
    Title: CDK11p58 Promotes Microglia Activation via Inducing Cyclin D3 Nuclear Localization.
  3. These data suggest that cyclin D3/CDK11p58 signaling is involved in the negative regulation of AR function.
    Title: Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor.
  4. Cdc2l1 is a previously unrecognized member of the Hh signal transduction cascade.
    Title: Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.
  5. CDK11(p58) is expressed in proliferating germ cells in the early stages of developing testes
    Title: Protein expression pattern of CDK11(p58) during testicular development in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of centrosome cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 11B
Names
PITSLRE proteins
PITSLRE serine/threonine-protein kinase CDC2L1
cell division cycle 2 homolog-like 1
cell division cycle 2 homolog-like 2
cell division cycle 2-like 1
cell division cycle 2-like 2
cell division cycle 2-like protein kinase 1
cell division protein kinase 11
cyclin-dependent kinase 11
galactosyltransferase-associated protein kinase p58/GTA
NP_001334237.1
NP_001342496.1
NP_001342497.1
NP_001342498.1
NP_031687.2
XP_006538574.1
XP_030108992.1
XP_030108993.1
XP_030108995.1
XP_030108997.1
XP_030108998.1
XP_036019503.1
XP_036019504.1
XP_036019506.1
XP_036019507.1
XP_036019508.1
XP_036019509.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347308.1 → NP_001334237.1  cyclin-dependent kinase 11B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL627405
    Consensus CDS
    CCDS84837.1
    UniProtKB/Swiss-Prot
    P24788
    UniProtKB/TrEMBL
    A2A9P6
    Conserved Domains (1) summary
    cd07843
    Location:387 → 678
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  2. NM_001355567.1 → NP_001342496.1  cyclin-dependent kinase 11B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region,compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is one aa shorter than isoform 1.
    Source sequence(s)
    AA210166, AK077668, AK135402, AL627405
    Conserved Domains (1) summary
    cd07843
    Location:420 → 711
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  3. NM_001355568.1 → NP_001342497.1  cyclin-dependent kinase 11B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA210166, AK077668, AK135402, AL627405, BY739008
    Consensus CDS
    CCDS84837.1
    UniProtKB/TrEMBL
    A2A9P6
    Related
    ENSMUSP00000101223.2, ENSMUST00000105598.2
    Conserved Domains (1) summary
    cd07843
    Location:387 → 678
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  4. NM_001355569.1 → NP_001342498.1  cyclin-dependent kinase 11B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA210166, AK077668, AK135402, AL627405, BY739008
    Conserved Domains (1) summary
    cd07843
    Location:76 → 367
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  5. NM_007661.4 → NP_031687.2  cyclin-dependent kinase 11B isoform 1

    See identical proteins and their annotated locations for NP_031687.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA210166, AK077668, AK135402, AL627405
    Consensus CDS
    CCDS19033.1
    UniProtKB/Swiss-Prot
    P24788, Q8BP53
    Related
    ENSMUSP00000070527.4, ENSMUST00000067081.10
    Conserved Domains (1) summary
    cd07843
    Location:421 → 712
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155709293..155734392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253133.2 → XP_030108993.1  cyclin-dependent kinase 11B isoform X2

    UniProtKB/TrEMBL
    A2A9P6
    Conserved Domains (1) summary
    cd07843
    Location:387 → 678
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  2. XM_036163610.1 → XP_036019503.1  cyclin-dependent kinase 11B isoform X3

    Conserved Domains (1) summary
    cd07843
    Location:386 → 677
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  3. XM_030253132.2 → XP_030108992.1  cyclin-dependent kinase 11B isoform X1

    UniProtKB/Swiss-Prot
    Q8BP53
    Conserved Domains (1) summary
    cd07843
    Location:421 → 712
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  4. XM_036163615.1 → XP_036019508.1  cyclin-dependent kinase 11B isoform X5

    Conserved Domains (1) summary
    cd07843
    Location:76 → 367
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  5. XM_030253137.2 → XP_030108997.1  cyclin-dependent kinase 11B isoform X4

    Conserved Domains (1) summary
    cd07843
    Location:204 → 495
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  6. XM_036163611.1 → XP_036019504.1  cyclin-dependent kinase 11B isoform X4

    Conserved Domains (1) summary
    cd07843
    Location:204 → 495
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  7. XM_030253138.2 → XP_030108998.1  cyclin-dependent kinase 11B isoform X4

    Conserved Domains (1) summary
    cd07843
    Location:204 → 495
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  8. XM_036163614.1 → XP_036019507.1  cyclin-dependent kinase 11B isoform X4

    Conserved Domains (1) summary
    cd07843
    Location:204 → 495
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  9. XM_006538511.4 → XP_006538574.1  cyclin-dependent kinase 11B isoform X2

    See identical proteins and their annotated locations for XP_006538574.1

    UniProtKB/Swiss-Prot
    P24788
    UniProtKB/TrEMBL
    A2A9P6
    Conserved Domains (1) summary
    cd07843
    Location:387 → 678
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  10. XM_030253135.1 → XP_030108995.1  cyclin-dependent kinase 11B isoform X3

    Conserved Domains (1) summary
    cd07843
    Location:386 → 677
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  11. XM_036163613.1 → XP_036019506.1  cyclin-dependent kinase 11B isoform X4

    Conserved Domains (1) summary
    cd07843
    Location:204 → 495
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

  12. XM_036163616.1 → XP_036019509.1  cyclin-dependent kinase 11B isoform X5

    Conserved Domains (1) summary
    cd07843
    Location:76 → 367
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

RNA

  1. XR_004941802.1 RNA Sequence

  2. XR_004941803.1 RNA Sequence

  3. XR_004941804.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24788.2 GenPept UniProtKB/Swiss-Prot:P24788

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