U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cdk11b cyclin dependent kinase 11B [ Mus musculus (house mouse) ]

Gene ID: 12537, updated on 12-Feb-2024

Summary

Official Symbol
Cdk11bprovided by MGI
Official Full Name
cyclin dependent kinase 11Bprovided by MGI
Primary source
MGI:MGI:88353
See related
Ensembl:ENSMUSG00000029062 AllianceGenome:MGI:88353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p58; Cdk11; Cdc11b; Cdc2l1; Cdc2l2; CDK11-p46; CDK11-p58; CDK11-p110
Summary
Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Located in nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; early embryo; and integumental system. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.0), large intestine adult (RPKM 15.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cdk11b in Genome Data Viewer
Location:
4 E2; 4 86.73 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155709303..155734392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155624841..155649935)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E340 Neighboring gene STARR-positive B cell enhancer ABC_E10296 Neighboring gene NAD kinase Neighboring gene STARR-positive B cell enhancer ABC_E3559 Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene matrix metallopeptidase 23 Neighboring gene STARR-seq mESC enhancer starr_12269 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_12270 Neighboring gene STARR-seq mESC enhancer starr_12271 Neighboring gene fibronectin type III domain containing 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 11B
Names
PITSLRE proteins
PITSLRE serine/threonine-protein kinase CDC2L1
cell division cycle 2 homolog-like 1
cell division cycle 2 homolog-like 2
cell division cycle 2-like 1
cell division cycle 2-like 2
cell division cycle 2-like protein kinase 1
cell division protein kinase 11
cyclin-dependent kinase 11
galactosyltransferase-associated protein kinase p58/GTA
NP_001334237.1
NP_001342496.1
NP_001342497.1
NP_001342498.1
NP_001406922.1
NP_001406923.1
NP_001406924.1
NP_001406925.1
NP_001406926.1
NP_001406927.1
NP_001406928.1
NP_001406929.1
NP_031687.2
XP_036019504.1
XP_036019506.1
XP_036019507.1
XP_036019509.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347308.2NP_001334237.1  cyclin-dependent kinase 11B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627405
    Consensus CDS
    CCDS84837.1
    UniProtKB/TrEMBL
    A2A9P6
    Conserved Domains (1) summary
    cd07843
    Location:387678
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  2. NM_001355567.2NP_001342496.1  cyclin-dependent kinase 11B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL627405
    Conserved Domains (1) summary
    cd07843
    Location:420711
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  3. NM_001355568.2NP_001342497.1  cyclin-dependent kinase 11B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627405
    Consensus CDS
    CCDS84837.1
    UniProtKB/TrEMBL
    A2A9P6
    Related
    ENSMUSP00000101223.2, ENSMUST00000105598.2
    Conserved Domains (1) summary
    cd07843
    Location:387678
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  4. NM_001355569.2NP_001342498.1  cyclin-dependent kinase 11B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627405
    UniProtKB/TrEMBL
    Q8R190
    Conserved Domains (1) summary
    cd07843
    Location:76367
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  5. NM_001419993.1NP_001406922.1  cyclin-dependent kinase 11B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627405
  6. NM_001419994.1NP_001406923.1  cyclin-dependent kinase 11B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL627405
    UniProtKB/Swiss-Prot
    P24788, Q3UI03, Q61399, Q7TST4, Q8BP53
  7. NM_001419995.1NP_001406924.1  cyclin-dependent kinase 11B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627405
    UniProtKB/TrEMBL
    A2A9P6
  8. NM_001419996.1NP_001406925.1  cyclin-dependent kinase 11B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627405
    UniProtKB/TrEMBL
    A2A9P6
  9. NM_001419997.1NP_001406926.1  cyclin-dependent kinase 11B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627405
  10. NM_001419998.1NP_001406927.1  cyclin-dependent kinase 11B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL627405
  11. NM_001419999.1NP_001406928.1  cyclin-dependent kinase 11B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL627405
  12. NM_001420000.1NP_001406929.1  cyclin-dependent kinase 11B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627405
    UniProtKB/TrEMBL
    Q8R190
  13. NM_007661.5NP_031687.2  cyclin-dependent kinase 11B isoform 1

    See identical proteins and their annotated locations for NP_031687.2

    Status: VALIDATED

    Source sequence(s)
    AL627405
    Consensus CDS
    CCDS19033.1
    UniProtKB/Swiss-Prot
    P24788, Q3UI03, Q61399, Q7TST4, Q8BP53
    Related
    ENSMUSP00000070527.4, ENSMUST00000067081.10
    Conserved Domains (1) summary
    cd07843
    Location:421712
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155709303..155734392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163611.1XP_036019504.1  cyclin-dependent kinase 11B isoform X4

    Conserved Domains (1) summary
    cd07843
    Location:204495
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  2. XM_036163614.1XP_036019507.1  cyclin-dependent kinase 11B isoform X4

    Conserved Domains (1) summary
    cd07843
    Location:204495
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  3. XM_036163613.1XP_036019506.1  cyclin-dependent kinase 11B isoform X4

    Conserved Domains (1) summary
    cd07843
    Location:204495
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
  4. XM_036163616.1XP_036019509.1  cyclin-dependent kinase 11B isoform X5

    UniProtKB/TrEMBL
    Q8R190
    Conserved Domains (1) summary
    cd07843
    Location:76367
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

RNA

  1. XR_004941802.1 RNA Sequence

  2. XR_004941803.1 RNA Sequence

  3. XR_004941804.1 RNA Sequence