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ZNF516 zinc finger protein 516 [ Homo sapiens (human) ]

Gene ID: 9658, updated on 22-Aug-2020

Summary

Official Symbol
ZNF516provided by HGNC
Official Full Name
zinc finger protein 516provided by HGNC
Primary source
HGNC:HGNC:28990
See related
Ensembl:ENSG00000101493 MIM:615114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT287
Summary
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
Expression
Broad expression in endometrium (RPKM 13.5), testis (RPKM 10.5) and 24 other tissues See more
Orthologs

Genomic context

See ZNF516 in Genome Data Viewer
Location:
18q23
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (76357682..76495255, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (74069637..74207146, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372210 Neighboring gene uncharacterized LOC105372209 Neighboring gene uncharacterized LOC105372211 Neighboring gene ZNF516 antisense RNA 1 Neighboring gene ZNF516 divergent transcript Neighboring gene long intergenic non-protein coding RNA 908

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of recipient genotype and medium-term kidney allograft function.
GeneReviews: Not available
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
GeneReviews: Not available
GWAS of dental caries patterns in the permanent dentition.
GeneReviews: Not available
Joint influence of small-effect genetic variants on human longevity.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 516 (ZNF516) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
adipose tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cold IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032949.1 RefSeqGene

    Range
    4949..142509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014643.4NP_055458.1  zinc finger protein 516

    See identical proteins and their annotated locations for NP_055458.1

    Status: REVIEWED

    Source sequence(s)
    AC009716, AC018413, BC108287, D86975
    Consensus CDS
    CCDS74234.1
    UniProtKB/Swiss-Prot
    Q92618
    UniProtKB/TrEMBL
    Q2YDX2
    Related
    ENSP00000394757.2, ENST00000443185.7
    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    76357682..76495255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526273.3XP_011524575.1  zinc finger protein 516 isoform X1

    See identical proteins and their annotated locations for XP_011524575.1

    UniProtKB/Swiss-Prot
    Q92618
    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011526274.3XP_011524576.1  zinc finger protein 516 isoform X1

    See identical proteins and their annotated locations for XP_011524576.1

    UniProtKB/Swiss-Prot
    Q92618
    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026097.2XP_016881586.1  zinc finger protein 516 isoform X1

    UniProtKB/Swiss-Prot
    Q92618
    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011526276.2XP_011524578.1  zinc finger protein 516 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011526269.2XP_011524571.1  zinc finger protein 516 isoform X1

    See identical proteins and their annotated locations for XP_011524571.1

    UniProtKB/Swiss-Prot
    Q92618
    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011526270.3XP_011524572.1  zinc finger protein 516 isoform X1

    See identical proteins and their annotated locations for XP_011524572.1

    UniProtKB/Swiss-Prot
    Q92618
    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011526271.3XP_011524573.1  zinc finger protein 516 isoform X1

    See identical proteins and their annotated locations for XP_011524573.1

    UniProtKB/Swiss-Prot
    Q92618
    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain
  8. XM_011526275.2XP_011524577.1  zinc finger protein 516 isoform X1

    See identical proteins and their annotated locations for XP_011524577.1

    UniProtKB/Swiss-Prot
    Q92618
    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain
  9. XM_011526277.2XP_011524579.1  zinc finger protein 516 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:3290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3656
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:3456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:4873
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_935268.2 RNA Sequence

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