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TRIP13 thyroid hormone receptor interactor 13 [ Homo sapiens (human) ]

Gene ID: 9319, updated on 6-Sep-2021

Summary

Official Symbol
TRIP13provided by HGNC
Official Full Name
thyroid hormone receptor interactor 13provided by HGNC
Primary source
HGNC:HGNC:12307
See related
Ensembl:ENSG00000071539 MIM:604507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MVA3; OOMD9; 16E1BP
Summary
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
Expression
Biased expression in testis (RPKM 14.2), lymph node (RPKM 3.0) and 10 other tissues See more
Orthologs
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Genomic context

See TRIP13 in Genome Data Viewer
Location:
5p15.33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (892884..919348)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (892999..918235)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene signal peptidase complex subunit 2 pseudogene 3 Neighboring gene bromodomain containing 9 Neighboring gene uncharacterized LOC100506688 Neighboring gene Sharpr-MPRA regulatory region 4144

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
GeneReviews: Not available
Mosaic variegated aneuploidy syndrome 3
MedGen: C4539839 OMIM: 617598 GeneReviews: Not available
Compare labs
Oocyte maturation defect 9
MedGen: C5436599 OMIM: 619011 GeneReviews: Not available
not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, thyroid hormone receptor interactor 13 (TRIP13), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in female meiosis I IEA
Inferred from Electronic Annotation
more info
 
involved_in male meiosis I IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic recombination checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in reciprocal meiotic recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptonemal complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pachytene checkpoint protein 2 homolog
Names
16E1-BP
HPV16 E1 protein binding protein
SH3TC1/TRIP13 fusion
TR-interacting protein 13
TRIP-13
human papillomavirus type 16 E1 protein-binding protein
thyroid receptor-interacting protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166260.2NP_001159732.1  pachytene checkpoint protein 2 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122719, AK310376
    Related
    ENST00000512024.5
    Conserved Domains (2) summary
    COG0464
    Location:136289
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:175285
    AAA; ATPase family associated with various cellular activities (AAA)
  2. NM_004237.4NP_004228.1  pachytene checkpoint protein 2 homolog isoform 1

    See identical proteins and their annotated locations for NP_004228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122719, BC019294, BM999741, DB443523
    Consensus CDS
    CCDS3858.1
    UniProtKB/Swiss-Prot
    Q15645
    Related
    ENSP00000166345.3, ENST00000166345.8
    Conserved Domains (1) summary
    COG0464
    Location:136360
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    892884..919348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514163.2XP_011512465.1  pachytene checkpoint protein 2 homolog isoform X1

    See identical proteins and their annotated locations for XP_011512465.1

    UniProtKB/Swiss-Prot
    Q15645
    Conserved Domains (1) summary
    COG0464
    Location:136360
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
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