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TRIP13 thyroid hormone receptor interactor 13 [ Homo sapiens (human) ]

Gene ID: 9319, updated on 3-Nov-2024

Summary

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Official Symbol
TRIP13provided by HGNC
Official Full Name
thyroid hormone receptor interactor 13provided by HGNC
Primary source
HGNC:HGNC:12307
See related
Ensembl:ENSG00000071539 MIM:604507; AllianceGenome:HGNC:12307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MVA3; OOMD9; 16E1BP; OZEMA9
Summary
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
Expression
Biased expression in testis (RPKM 14.2), lymph node (RPKM 3.0) and 10 other tissues See more
Orthologs
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Genomic context

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See TRIP13 in Genome Data Viewer
Location:
5p15.33
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (892884..919348)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (798936..824664)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (892999..918235)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:827809-828355 Neighboring gene signal peptidase complex subunit 2 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:849793-850444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:850445-851094 Neighboring gene bromodomain containing 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:892285-892917 Neighboring gene Sharpr-MPRA regulatory region 1606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:916909-917478 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:918895-919438 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:919439-919982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15879 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:929600-929776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22303 Neighboring gene uncharacterized LOC124900931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:965451-965952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:991246-991960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:994888-995388 Neighboring gene long intergenic non-protein coding RNA 2982

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MiR-515-5p acts as a tumor suppressor via targeting TRIP13 in prostate cancer. Zhang X, et al. Int J Biol Macromol, 2019 May 15. PMID 30685303
  2. TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint. Ma HT, et al. Cell Rep, 2016 Feb 9. PMID 26832417
  3. [Regulation of TRIP13 on Proliferation and Apoptosis of B-Cell Lymphoma Cells and Its Mechanism]. Yan SR, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2021 Oct. PMID 34627428
  4. Increased expression of TRIP13 drives the tumorigenesis of bladder cancer in association with the EGFR signaling pathway. Gao Y, et al. Int J Biol Sci, 2019. PMID 31337978, Free PMC Article
  5. Loss of thyroid hormone receptor interactor 13 inhibits cell proliferation and survival in human chronic lymphocytic leukemia. Zhou K, et al. Oncotarget, 2017 Apr 11. PMID 28424416, Free PMC Article

See all (176) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of TRIP13 in human cancer development.
    Title: Role of TRIP13 in human cancer development.
  2. TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21.
    Title: TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21.
  3. TRIP13 Activates Glycolysis to Promote Cell Stemness and Strengthen Doxorubicin Resistance of Colorectal Cancer Cells.
    Title: TRIP13 Activates Glycolysis to Promote Cell Stemness and Strengthen Doxorubicin Resistance of Colorectal Cancer Cells.
  4. High expression of TRIP13 is associated with tumor progression in H. pylori infection induced gastric cancer.
    Title: High expression of TRIP13 is associated with tumor progression in H. pylori infection induced gastric cancer.
  5. Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma.
    Title: Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma.
  6. Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma.
    Title: Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma.
  7. Novel mutations in TRIP13 lead to female infertility with oocyte maturation arrest.
    Title: Novel mutations in TRIP13 lead to female infertility with oocyte maturation arrest.
  8. TRIP13 overexpression promotes gefitinib resistance in nonsmall cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.
    Title: TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.
  9. MiR-129-5p/TRIP13 affects malignant phenotypes of colorectal cancer cells.
    Title: MiR-129-5p/TRIP13 affects malignant phenotypes of colorectal cancer cells.
  10. Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.
    Title: Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Mosaic variegated aneuploidy syndrome 3
MedGen: C4539839 OMIM: 617598 GeneReviews: Not available
Compare labs
Oocyte maturation defect 9
MedGen: C5436599 OMIM: 619011 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, thyroid hormone receptor interactor 13 (TRIP13), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in female meiosis I IEA
Inferred from Electronic Annotation
more info
  
involved_in male meiosis I IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic recombination checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptonemal complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pachytene checkpoint protein 2 homolog
Names
16E1-BP
HPV16 E1 protein binding protein
SH3TC1/TRIP13 fusion
TR-interacting protein 13
TRIP-13
human papillomavirus type 16 E1 protein-binding protein
thyroid receptor-interacting protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166260.2 → NP_001159732.1  pachytene checkpoint protein 2 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122719, AK310376
    UniProtKB/TrEMBL
    H0YAL2
    Related
    ENST00000512024.5
    Conserved Domains (2) summary
    COG0464
    Location:136 → 289
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:175 → 285
    AAA; ATPase family associated with various cellular activities (AAA)

  2. NM_004237.4 → NP_004228.1  pachytene checkpoint protein 2 homolog isoform 1

    See identical proteins and their annotated locations for NP_004228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122719, BC019294, BM999741, DB443523
    Consensus CDS
    CCDS3858.1
    UniProtKB/Swiss-Prot
    C9K0T3, D3DTC0, O15324, Q15645
    Related
    ENSP00000166345.3, ENST00000166345.8
    Conserved Domains (1) summary
    COG0464
    Location:136 → 360
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    892884..919348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514163.2 → XP_011512465.1  pachytene checkpoint protein 2 homolog isoform X1

    See identical proteins and their annotated locations for XP_011512465.1

    UniProtKB/Swiss-Prot
    C9K0T3, D3DTC0, O15324, Q15645
    Conserved Domains (1) summary
    COG0464
    Location:136 → 360
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

  2. XM_047417879.1 → XP_047273835.1  pachytene checkpoint protein 2 homolog isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    798936..824664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353801.1 → XP_054209776.1  pachytene checkpoint protein 2 homolog isoform X1

    UniProtKB/Swiss-Prot
    C9K0T3, D3DTC0, O15324, Q15645

  2. XM_054353802.1 → XP_054209777.1  pachytene checkpoint protein 2 homolog isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15645.2 GenPept UniProtKB/Swiss-Prot:Q15645

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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