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Trip13 thyroid hormone receptor interactor 13 [ Mus musculus (house mouse) ]

Gene ID: 69716, updated on 26-Sep-2022

Summary

Official Symbol
Trip13provided by MGI
Official Full Name
thyroid hormone receptor interactor 13provided by MGI
Primary source
MGI:MGI:1916966
See related
Ensembl:ENSMUSG00000021569 AllianceGenome:MGI:1916966
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D13Ertd328e; 2410002G23Rik
Summary
Enables identical protein binding activity. Involved in double-strand break repair; gamete generation; and meiosis I. Acts upstream of or within gamete generation. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 3. Orthologous to human TRIP13 (thyroid hormone receptor interactor 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 11.3), placenta adult (RPKM 8.5) and 11 other tissues See more
Orthologs
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Genomic context

See Trip13 in Genome Data Viewer
Location:
13 C1; 13 40.15 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74060569..74085914, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73912450..73937795, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30303 Neighboring gene predicted gene, 30432 Neighboring gene U7 small nuclear RNA Neighboring gene bromodomain containing 9 Neighboring gene predicted gene, 41002 Neighboring gene zinc finger, DHHC domain containing 11 Neighboring gene ribosomal protein S29 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within female meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic recombination checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oocyte maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pachytene checkpoint protein 2 homolog
Names
TR-interacting protein 13
TRIP-13
thyroid receptor-interacting protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027182.2NP_081458.1  pachytene checkpoint protein 2 homolog

    See identical proteins and their annotated locations for NP_081458.1

    Status: PROVISIONAL

    Source sequence(s)
    AK146877
    Consensus CDS
    CCDS26637.1
    UniProtKB/Swiss-Prot
    Q3UA06, Q9CWW8
    UniProtKB/TrEMBL
    A0A8C6MWU0
    Related
    ENSMUSP00000022053.9, ENSMUST00000022053.11
    Conserved Domains (2) summary
    smart00382
    Location:172322
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:175320
    AAA; ATPase family associated with various cellular activities (AAA)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    74060569..74085914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_873456.3 RNA Sequence