U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IL1RL1 interleukin 1 receptor like 1 [ Homo sapiens (human) ]

Gene ID: 9173, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
IL1RL1provided by HGNC
Official Full Name
interleukin 1 receptor like 1provided by HGNC
Primary source
HGNC:HGNC:5998
See related
Ensembl:ENSG00000115602 MIM:601203; AllianceGenome:HGNC:5998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R
Summary
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene, IL1RL1 (GeneID: 9173) which has the alias ST2, is found on chromosome 2. IL1RL1 encodes a member of the interleukin 1 receptor family. IL1RL1 has been confused in the published literature with ST2 (GeneID: 6761) on chromosome 11 which is a region that represents a putative locus associated with various forms of cancer. [23 Jun 2016]
Expression
Biased expression in placenta (RPKM 51.1), kidney (RPKM 5.3) and 3 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IL1RL1 in Genome Data Viewer
Location:
2q12.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (102311563..102352356)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102769811..102810635)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102928023..102968497)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102803139-102803668 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:102813537-102814736 Neighboring gene interleukin 1 receptor like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851302-102851802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851803-102852303 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102854175-102855374 Neighboring gene Sharpr-MPRA regulatory region 14071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102867123-102867716 Neighboring gene CFAP144 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102972025-102972526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16306 Neighboring gene interleukin 18 receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16307 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 pseudogene 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection. Wang Y, et al. Circulation, 2018 Jan 16. PMID 29146682
  2. The levels of soluble ST2 in sera and bullous fluid from patients with bullous pemphigoid. Wakatabi K, et al. Eur J Dermatol, 2012 May-Jun. PMID 22494834
  3. Characterization of interleukin-33 and soluble ST2 in serum and their association with disease severity in patients with chronic kidney disease. Bao YS, et al. J Clin Immunol, 2012 Jun. PMID 22203232
  4. IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma. Hentschke I, et al. Sci Rep, 2017 Mar 6. PMID 28262704, Free PMC Article
  5. Prognostic value of soluble ST2 in an unselected cohort of patients admitted to an intensive care unit - The Linz Intensive Care Unit (LICU) study. Dieplinger B, et al. Clin Chim Acta, 2012 Mar 22. PMID 22155704

See all (287) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ST2 and IL-33 polymorphisms and the development of childhood asthma: a prospective birth cohort study in Finnish children.
    Title: ST2 and IL-33 polymorphisms and the development of childhood asthma: a prospective birth cohort study in Finnish children.
  2. Salivary IL-33 and sST2 levels in relation to TLR2 rs111200466 polymorphism and periodontitis.
    Title: Salivary IL-33 and sST2 levels in relation to TLR2 rs111200466 polymorphism and periodontitis.
  3. A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
    Title: A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
  4. The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial-mesenchymal transition by phosphorylating beta-catenin.
    Title: The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial-mesenchymal transition by phosphorylating β-catenin.
  5. Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.
    Title: Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex.
  6. IL-33-ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways.
    Title: IL-33-ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways.
  7. An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-epsilon4 in female patients with Alzheimer's disease.
    Title: An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease.
  8. Single nucleotide variants in the IL33 and IL1RL1 (ST2) genes are associated with periodontitis and with Aggregatibacter actinomycetemcomitans in the dental plaque biofilm: A putative role in understanding the host immune response in periodontitis.
    Title: Single nucleotide variants in the IL33 and IL1RL1 (ST2) genes are associated with periodontitis and with Aggregatibacter actinomycetemcomitans in the dental plaque biofilm: A putative role in understanding the host immune response in periodontitis.
  9. Association between IL1RL1 gene polymorphisms and allergic rhinitis risk in the Chinese Han population.
    Title: Association between IL1RL1 gene polymorphisms and allergic rhinitis risk in the Chinese Han population.
  10. IL-33/ST2 axis contributes to the dermal fibrosis of systemic sclerosis via promoting fibroblasts activation.
    Title: IL-33/ST2 axis contributes to the dermal fibrosis of systemic sclerosis via promoting fibroblasts activation.
Submit: New GeneRIF Correction See all GeneRIFs (226)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
EBI GWAS Catalog
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
EBI GWAS Catalog
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
EBI GWAS Catalog
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
EBI GWAS Catalog
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
EBI GWAS Catalog
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
EBI GWAS Catalog
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog
Newly identified genetic risk variants for celiac disease related to the immune response.
EBI GWAS Catalog
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
In vitro infection with HIV-1 subtype B upregulates ST2L expression in primary human astrocytes and SKNMC cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC32623, DKFZp564N1164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables cytokine receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-33 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-33 receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in interleukin-33-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-33-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in macrophage differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interleukin-1 receptor-like 1
Names
growth stimulation-expressed
homolog of mouse growth stimulation-expressed
interleukin 1 receptor-related protein
NP_001269337.1
NP_003847.2
NP_057316.3
XP_006712902.1
XP_011510453.1
XP_054200480.1
XP_054200481.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282408.2 → NP_001269337.1  interleukin-1 receptor-like 1 isoform 3

    See identical proteins and their annotated locations for NP_001269337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, cause translation initiation at a downstream start codon and translation termination at a different stop codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK303389, AL117622, BC030975, BQ012352
    Consensus CDS
    CCDS74548.1
    UniProtKB/Swiss-Prot
    Q01638
    Related
    ENSP00000384822.2, ENST00000404917.6
    Conserved Domains (2) summary
    cd05757
    Location:1 → 87
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:3 → 80
    IG_like; Immunoglobulin like

  2. NM_003856.4 → NP_003847.2  interleukin-1 receptor-like 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_003847.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon and lacks several 3' terminal exons, and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL117622, BC030975, BQ012352
    Consensus CDS
    CCDS2058.1
    UniProtKB/TrEMBL
    E9PC41
    Related
    ENSP00000310371.2, ENST00000311734.6
    Conserved Domains (2) summary
    cd05756
    Location:16 → 104
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:118 → 204
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  3. NM_016232.5 → NP_057316.3  interleukin-1 receptor-like 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057316.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB012701, AC007248, AK291578, DB063031
    Consensus CDS
    CCDS2057.1
    UniProtKB/Swiss-Prot
    A8K6B3, B4E0I3, Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
    Related
    ENSP00000233954.1, ENST00000233954.6
    Conserved Domains (4) summary
    cd05757
    Location:118 → 204
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:21 → 104
    IG_like; Immunoglobulin like
    pfam01582
    Location:380 → 535
    TIR; TIR domain
    cl11960
    Location:16 → 104
    Ig; Immunoglobulin domain

RNA

  1. NR_104167.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, an additional internal exon which includes a premature stop codon, and an alternate 3' segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB029084, AL117622, AL553735, BC030975, BQ012352, DA884586

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    102311563..102352356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512151.2 → XP_011510453.1  interleukin-1 receptor-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011510453.1

    UniProtKB/TrEMBL
    E9PC41
    Conserved Domains (2) summary
    cd05756
    Location:16 → 104
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:118 → 204
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  2. XM_006712839.4 → XP_006712902.1  interleukin-1 receptor-like 1 isoform X2

    See identical proteins and their annotated locations for XP_006712902.1

    UniProtKB/Swiss-Prot
    A8K6B3, B4E0I3, Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44
    Conserved Domains (4) summary
    cd05757
    Location:118 → 204
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:21 → 104
    IG_like; Immunoglobulin like
    pfam01582
    Location:380 → 535
    TIR; TIR domain
    cl11960
    Location:16 → 104
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    102769811..102810635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344505.1 → XP_054200480.1  interleukin-1 receptor-like 1 isoform X1

  2. XM_054344506.1 → XP_054200481.1  interleukin-1 receptor-like 1 isoform X2

    UniProtKB/Swiss-Prot
    A8K6B3, B4E0I3, Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173459.1: Suppressed sequence

    Description
    NM_173459.1: This RefSeq was permantly suppressed because it represented an alternate exon that was weakly supported and resulted in premature truncation of the protein and a transcript which is a nonsense-mediated decay (NMD) ca
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01638.4 GenPept UniProtKB/Swiss-Prot:Q01638

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous