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IL1RL1 interleukin 1 receptor like 1 [ Homo sapiens (human) ]

Gene ID: 9173, updated on 16-Feb-2020

Summary

Official Symbol
IL1RL1provided by HGNC
Official Full Name
interleukin 1 receptor like 1provided by HGNC
Primary source
HGNC:HGNC:5998
See related
Ensembl:ENSG00000115602 MIM:601203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R
Summary
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene, IL1RL1 (GeneID: 9173) which has the alias ST2, is found on chromosome 2. IL1RL1 encodes a member of the interleukin 1 receptor family. IL1RL1 has been confused in the published literature with ST2 (GeneID: 6761) on chromosome 11 which is a region that represents a putative locus associated with various forms of cancer. [23 Jun 2016]
Expression
Biased expression in placenta (RPKM 51.1), kidney (RPKM 5.3) and 3 other tissues See more
Orthologs

Genomic context

See IL1RL1 in Genome Data Viewer
Location:
2q12.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (102311502..102352367)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102927962..102968497)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor like 2 Neighboring gene family with sequence similarity 183 member D, pseudogene Neighboring gene interleukin 18 receptor 1 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
NHGRI GWA Catalog
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
NHGRI GWA Catalog
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
NHGRI GWA Catalog
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
NHGRI GWA Catalog
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
NHGRI GWA Catalog
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog
Newly identified genetic risk variants for celiac disease related to the immune response.
NHGRI GWA Catalog
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
In vitro infection with HIV-1 subtype B upregulates ST2L expression in primary human astrocytes and SKNMC cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC32623, DKFZp564N1164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-33 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-33 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
immune response NAS
Non-traceable Author Statement
more info
PubMed 
interleukin-33-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of T-helper 1 type immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-1 receptor-like 1
Names
growth stimulation-expressed
homolog of mouse growth stimulation-expressed
interleukin 1 receptor-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282408.1NP_001269337.1  interleukin-1 receptor-like 1 isoform 3

    See identical proteins and their annotated locations for NP_001269337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, cause translation initiation at a downstream start codon and translation termination at a different stop codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB012701, AK303389, AL117622, BC030975, BQ012352
    Consensus CDS
    CCDS74548.1
    UniProtKB/Swiss-Prot
    Q01638
    Related
    ENSP00000384822.2, ENST00000404917.6
    Conserved Domains (2) summary
    cd05757
    Location:187
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:380
    IG_like; Immunoglobulin like
  2. NM_003856.4NP_003847.2  interleukin-1 receptor-like 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_003847.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon and lacks several 3' terminal exons, and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL117622, BC030975, BQ012352
    Consensus CDS
    CCDS2058.1
    UniProtKB/Swiss-Prot
    Q01638
    Related
    ENSP00000310371.2, ENST00000311734.6
    Conserved Domains (2) summary
    cd05756
    Location:16104
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:118204
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  3. NM_016232.5NP_057316.3  interleukin-1 receptor-like 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057316.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB012701, AC007248, AK291578, DB063031
    Consensus CDS
    CCDS2057.1
    UniProtKB/Swiss-Prot
    Q01638
    Related
    ENSP00000233954.1, ENST00000233954.6
    Conserved Domains (4) summary
    cd05757
    Location:118204
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:21104
    IG_like; Immunoglobulin like
    pfam01582
    Location:380535
    TIR; TIR domain
    cl11960
    Location:16104
    Ig; Immunoglobulin domain

RNA

  1. NR_104167.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, an additional internal exon which includes a premature stop codon, and an alternate 3' segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB029084, AL117622, AL553735, BC030975, BQ012352, DA884586

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    102311502..102352367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512151.1XP_011510453.1  interleukin-1 receptor-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011510453.1

    UniProtKB/Swiss-Prot
    Q01638
    Conserved Domains (2) summary
    cd05756
    Location:16104
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:118204
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  2. XM_006712839.3XP_006712902.1  interleukin-1 receptor-like 1 isoform X2

    See identical proteins and their annotated locations for XP_006712902.1

    UniProtKB/Swiss-Prot
    Q01638
    Conserved Domains (4) summary
    cd05757
    Location:118204
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:21104
    IG_like; Immunoglobulin like
    pfam01582
    Location:380535
    TIR; TIR domain
    cl11960
    Location:16104
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173459.1: Suppressed sequence

    Description
    NM_173459.1: This RefSeq was permantly suppressed because it represented an alternate exon that was weakly supported and resulted in premature truncation of the protein and a transcript which is a nonsense-mediated decay (NMD) ca
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