1IRA


Conserved Protein Domain Family
Ig2_IL1R_like

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cd05757: Ig2_IL1R_like (this model, PSSM-Id:143234 is obsolete and has been replaced by 409415)
Click on image for an interactive view with Cn3D
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
Ig2_IL1R_like: domain similar to the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with an accessory protein, IL1RAP. IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.
Statistics
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PSSM-Id: 143234
Aligned: 24 rows
Threshold Bit Score: 98.5439
Threshold Setting Gi: 47221999
Created: 30-Aug-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
antagonist
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:antagonist binding site
Evidence:
  • Structure:1IRA_Y; human IL1R binds to its antagonist IL1RA, contacts based on 3.5A distance.
    View structure with Cn3D
  • Citation:PMID 7867645
  • Comment:The naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ### ####      #    # #                                   #                      
1IRA_Y       109 AIFKQKLPVag-dGGLVCPYMEFFknen--nelPKLQWYKDCKPLLLDNIhfsgvkDRLIVMNVAekHRGNYTCHASyty 185 human
XP_001514614 142 PDDLIYRFPig-lSTIYCPNLDIYnn------sGDIQWFQNCKPLREAKYls--rkDFLLIIGATeaDSGNYTCQFVhne 212 platypus
BAB20891     114 PSRILYANEtr-kGKISCPTFRNYen------aTIIQWYKDCRPIQGERYfm--hdPYIFIENLNkeDDGYYTCQFTyth 184 chicken
XP_001371281 179 VLYTSTEGSnt-gSWIYCPRYESYnk------tSNFEWFKDCKALKGQKYfv--kkDYLIIQNTTaaDTGNYTCKFIhse 249 gray short-tail...
Q01638       117 LMYSTVSGSek-nSKIYCPTIDLYnw------tAPLEWFKNCQALQGSRYra--hkSFLVIDNVMteDAGDYTCKFIhne 187 human
P14719       123 LMYSTVRGSdk-nFKITCPTIDLYnw------tAPVQWFKNCKALQEPRFra--hrSYLFIDNVThdDEGDYTCQFThae 193 house mouse
XP_422719    263 KPVEQMFYLeyanEKITCPDIDGFypa---svtPTVKWYQSCRLVDGFNErhp-qgSKLVIGVVRsaYEGNYTCIVTfkd 338 chicken
NP_001072367 146 IRYLEKAEVtk-kKQIICPDIDDYrtl---nedIEVAWYKECKPKKWRSLiiq-kgNSLLIQDVQkeDGGNYTCELKyeg 220 western clawed ...
XP_420348    135 IRYLEKSEVtk-rKTISCPDIEDYkid---sqePDVVWYKECKPKMWRSVviq-kgNTLLIQEVQeeDGGNYTCELKfeg 209 chicken
CAG08254     134 PRTVGKDLTngvpDRLSCPLNDYItklnsynvtSSITWYKDCEAIENRNGrytymkTKLMIAKVTseDHGLYTCTLTftl 213 Tetraodon nigro...
XP_001514614 142 PDDLIYRFPig-lSTIYCPNLDIYnn------sGDIQWFQNCKPLREAKYls--rkDFLLIIGATeaDSGNYTCQFVhne 212 platypus
BAB20891     114 PSRILYANEtr-kGKISCPTFRNYen------aTIIQWYKDCRPIQGERYfm--hdPYIFIENLNkeDDGYYTCQFTyth 184 chicken
XP_001371281 179 VLYTSTEGSnt-gSWIYCPRYESYnk------tSNFEWFKDCKALKGQKYfv--kkDYLIIQNTTaaDTGNYTCKFIhse 249 gray short-tail...
Q01638       117 LMYSTVSGSek-nSKIYCPTIDLYnw------tAPLEWFKNCQALQGSRYra--hkSFLVIDNVMteDAGDYTCKFIhne 187 human
P14719       123 LMYSTVRGSdk-nFKITCPTIDLYnw------tAPVQWFKNCKALQEPRFra--hrSYLFIDNVThdDEGDYTCQFThae 193 house mouse
XP_422719    263 KPVEQMFYLeyanEKITCPDIDGFypa---svtPTVKWYQSCRLVDGFNErhp-qgSKLVIGVVRsaYEGNYTCIVTfkd 338 chicken
NP_001072367 146 IRYLEKAEVtk-kKQIICPDIDDYrtl---nedIEVAWYKECKPKKWRSLiiq-kgNSLLIQDVQkeDGGNYTCELKyeg 220 western clawed ...
XP_420348    135 IRYLEKSEVtk-rKTISCPDIEDYkid---sqePDVVWYKECKPKMWRSVviq-kgNTLLIQEVQeeDGGNYTCELKfeg 209 chicken
CAG08254     134 PRTVGKDLTngvpDRLSCPLNDYItklnsynvtSSITWYKDCEAIENRNGrytymkTKLMIAKVTseDHGLYTCTLTftl 213 Tetraodon nigro...
Feature 1                       # 
1IRA_Y       186 lGKQYPITRVIEFITLE 202 human
XP_001514614 213 kGTIYPVTATVEFKFKE 229 platypus
BAB20891     185 rGRVFNVSATRIFVSEA 201 chicken
XP_001371281 250 nGVNYNVTATRPLIFQG 266 gray short-tailed opossum
Q01638       188 nGANYSVTATRSFTVKD 204 human
P14719       194 nGTNYIVTATRSFTVEE 210 house mouse
XP_422719    339 hGRTYNLTRTVKMKVVG 355 chicken
NP_001072367 221 rLIRRTIQLKVTALFTT 237 western clawed frog
XP_420348    210 kLIRRTVELKVTALLTD 226 chicken
CAG08254     214 nGVTGSVSETIDAEVTV 230 Tetraodon nigroviridis
XP_001514614 213 kGTIYPVTATVEFKFKE 229 platypus
BAB20891     185 rGRVFNVSATRIFVSEA 201 chicken
XP_001371281 250 nGVNYNVTATRPLIFQG 266 gray short-tailed opossum
Q01638       188 nGANYSVTATRSFTVKD 204 human
P14719       194 nGTNYIVTATRSFTVEE 210 house mouse
XP_422719    339 hGRTYNLTRTVKMKVVG 355 chicken
NP_001072367 221 rLIRRTIQLKVTALFTT 237 western clawed frog
XP_420348    210 kLIRRTVELKVTALLTD 226 chicken
CAG08254     214 nGVTGSVSETIDAEVTV 230 Tetraodon nigroviridis

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