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Il1rl1 interleukin 1 receptor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 17082, updated on 31-Jan-2023

Summary

Official Symbol
Il1rl1provided by MGI
Official Full Name
interleukin 1 receptor-like 1provided by MGI
Primary source
MGI:MGI:98427
See related
Ensembl:ENSMUSG00000026069 AllianceGenome:MGI:98427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
Summary
Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of cytokine production. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 1.3), liver E14 (RPKM 1.3) and 16 other tissues See more
Orthologs
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Genomic context

See Il1rl1 in Genome Data Viewer
Location:
1 B; 1 19.19 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40444025..40504578)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40404864..40465418)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor, type I Neighboring gene interleukin 1 receptor-like 2 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene interleukin 18 receptor 1 Neighboring gene interleukin 18 receptor accessory protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (9) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-33 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-33 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-1 receptor-like 1
Names
interleukin-33 receptor alpha chain
lymphocyte antigen 84
NP_001020773.1
NP_001281100.1
NP_034873.2
XP_006495804.1
XP_006495807.1
XP_036018391.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025602.3NP_001020773.1  interleukin-1 receptor-like 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001020773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC167126, AC167168, AI573400
    Consensus CDS
    CCDS35548.1
    UniProtKB/Swiss-Prot
    P14719, Q05208
    Related
    ENSMUSP00000095379.4, ENSMUST00000097772.10
    Conserved Domains (4) summary
    pfam01582
    Location:385540
    TIR; TIR domain
    cd00096
    Location:3742
    Ig; Ig strand B [structural motif]
    cd05757
    Location:124210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:3397
    Ig; Immunoglobulin domain
  2. NM_001294171.1NP_001281100.1  interleukin-1 receptor-like 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001281100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC167126, AK033417, BC051445, BY228016
    Consensus CDS
    CCDS56626.1
    UniProtKB/Swiss-Prot
    P14719
    UniProtKB/TrEMBL
    Q5D095
    Related
    ENSMUSP00000134351.2, ENSMUST00000174335.8
    Conserved Domains (3) summary
    cd05757
    Location:124210
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:27110
    IG_like; Immunoglobulin like
    cl11960
    Location:27110
    Ig; Immunoglobulin domain
  3. NM_010743.3NP_034873.2  interleukin-1 receptor-like 1 isoform b precursor

    See identical proteins and their annotated locations for NP_034873.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC167126, AC167168, AK033417
    Consensus CDS
    CCDS56626.1
    UniProtKB/Swiss-Prot
    P14719
    UniProtKB/TrEMBL
    Q5D095
    Related
    ENSMUSP00000133784.2, ENSMUST00000173514.8
    Conserved Domains (3) summary
    cd05757
    Location:124210
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:27110
    IG_like; Immunoglobulin like
    cl11960
    Location:27110
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    40444025..40504578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162498.1XP_036018391.1  interleukin-1 receptor-like 1 isoform X1

    UniProtKB/Swiss-Prot
    Q05208
    Conserved Domains (4) summary
    pfam01582
    Location:385540
    TIR; TIR domain
    cd00096
    Location:3742
    Ig; Ig strand B [structural motif]
    cd05757
    Location:124210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:3397
    Ig; Immunoglobulin domain
  2. XM_006495744.3XP_006495807.1  interleukin-1 receptor-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006495807.1

    UniProtKB/Swiss-Prot
    P14719, Q05208
    Conserved Domains (4) summary
    pfam01582
    Location:385540
    TIR; TIR domain
    cd00096
    Location:3742
    Ig; Ig strand B [structural motif]
    cd05757
    Location:124210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:3397
    Ig; Immunoglobulin domain
  3. XM_006495741.1XP_006495804.1  interleukin-1 receptor-like 1 isoform X1

    See identical proteins and their annotated locations for XP_006495804.1

    UniProtKB/Swiss-Prot
    P14719, Q05208
    Related
    ENSMUSP00000054914.8, ENSMUST00000053043.8
    Conserved Domains (4) summary
    pfam01582
    Location:385540
    TIR; TIR domain
    cd00096
    Location:3742
    Ig; Ig strand B [structural motif]
    cd05757
    Location:124210
    Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
    cl11960
    Location:3397
    Ig; Immunoglobulin domain