Il1rl1 interleukin 1 receptor-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il1rl1provided by MGI
Official Full Name: interleukin 1 receptor-like 1provided by MGI
Primary source: MGI:MGI:98427
See related: Ensembl:ENSMUSG00000026069 AllianceGenome:MGI:98427
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
Summary: Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of cytokine production. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14.5 (RPKM 1.3), liver E14 (RPKM 1.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 19.19 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (40444025..40504578)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (40404864..40465418)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Setd2 supports GATA3[+]ST2[+] thymic-derived Treg cells and suppresses intestinal inflammation.
Title: Setd2 supports GATA3<sup>+</sup>ST2<sup>+</sup> thymic-derived Treg cells and suppresses intestinal inflammation.
ST2 and the alteration of cobalt, sodium, potassium and calcium concentration in acute inflammation.
Title: ST2 and the alteration of cobalt, sodium, potassium and calcium concentration in acute inflammation.
IL-33/ST2 axis contributes to the dermal fibrosis of systemic sclerosis via promoting fibroblasts activation.
Title: IL-33/ST2 axis contributes to the dermal fibrosis of systemic sclerosis via promoting fibroblasts activation.
IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus.
Title: IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus.
The potential role and regulatory mechanism of IL-33/ST2 axis on T lymphocytes during lipopolysaccharide stimulation or perinatal Listeria infection.
Title: The potential role and regulatory mechanism of IL-33/ST2 axis on T lymphocytes during lipopolysaccharide stimulation or perinatal Listeria infection.
A rapid and quantitative detection method for plasma soluble growth stimulating gene protein 2 based on time resolved fluorescence immunochromatography.
Title: A rapid and quantitative detection method for plasma soluble growth stimulating gene protein 2 based on time resolved fluorescence immunochromatography.
IL-33/ST2 receptor-dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice.
Title: IL-33/ST2 receptor-dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice.
ST2 deletion accelerates inflammatory-angiogenesis and remodeling in subcutaneous implants in mice.
Title: ST2 deletion accelerates inflammatory-angiogenesis and remodeling in subcutaneous implants in mice.
IL33 (Interleukin 33)/ST2 (Interleukin 1 Receptor-Like 1) Axis Drives Protective Microglial Responses and Promotes White Matter Integrity After Stroke.
Title: IL33 (Interleukin 33)/ST2 (Interleukin 1 Receptor-Like 1) Axis Drives Protective Microglial Responses and Promotes White Matter Integrity After Stroke.
The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI.
Title: The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI.

Submit: New GeneRIF Correction See all GeneRIFs (145)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (9)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M24843 (e-PCR)
- UniSTS:124946

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

D866 (e-PCR)
- UniSTS:128455

D1Mit122.1 (e-PCR), detects polymorphism
- UniSTS:128456

D13695 (e-PCR)
- UniSTS:178380

Homology

Homologs of the Il1rl1 gene: The Il1rl1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 294 organisms have orthologs with human gene Il1rl1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD(P)+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-33 binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables interleukin-33 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T-helper 1 type immune response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-5 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-1 receptor-like 1

Names: interleukin-33 receptor alpha chain; lymphocyte antigen 84

NP_001020773.1

EC 3.2.2.6

NP_001281100.1

EC 3.2.2.6

NP_034873.2

EC 3.2.2.6

XP_006495804.1

EC 3.2.2.6

XP_006495807.1

EC 3.2.2.6

XP_036018391.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025602.3 → NP_001020773.1 interleukin-1 receptor-like 1 isoform a precursor

See identical proteins and their annotated locations for NP_001020773.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AC167126, AC167168, AI573400

Consensus CDS

CCDS35548.1

UniProtKB/Swiss-Prot

P14719, Q05208

Related

ENSMUSP00000095379.4, ENSMUST00000097772.10

Conserved Domains (4) summary

pfam01582
Location:385 → 540

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:124 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 97

Ig; Immunoglobulin domain
NM_001294171.1 → NP_001281100.1 interleukin-1 receptor-like 1 isoform b precursor

See identical proteins and their annotated locations for NP_001281100.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon, lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AC167126, AK033417, BC051445, BY228016

Consensus CDS

CCDS56626.1

UniProtKB/Swiss-Prot

P14719

UniProtKB/TrEMBL

Q5D095

Related

ENSMUSP00000134351.2, ENSMUST00000174335.8

Conserved Domains (3) summary

cd05757
Location:124 → 210

Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

smart00410
Location:27 → 110

IG_like; Immunoglobulin like

cl11960
Location:27 → 110

Ig; Immunoglobulin domain
NM_010743.3 → NP_034873.2 interleukin-1 receptor-like 1 isoform b precursor

See identical proteins and their annotated locations for NP_034873.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AC167126, AC167168, AK033417

Consensus CDS

CCDS56626.1

UniProtKB/Swiss-Prot

P14719

UniProtKB/TrEMBL

Q5D095

Related

ENSMUSP00000133784.2, ENSMUST00000173514.8

Conserved Domains (3) summary

cd05757
Location:124 → 210

Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

smart00410
Location:27 → 110

IG_like; Immunoglobulin like

cl11960
Location:27 → 110

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

40444025..40504578

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162498.1 → XP_036018391.1 interleukin-1 receptor-like 1 isoform X1

UniProtKB/Swiss-Prot

Q05208

Conserved Domains (4) summary

pfam01582
Location:385 → 540

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:124 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 97

Ig; Immunoglobulin domain
XM_006495744.3 → XP_006495807.1 interleukin-1 receptor-like 1 isoform X1

See identical proteins and their annotated locations for XP_006495807.1

UniProtKB/Swiss-Prot

P14719, Q05208

Conserved Domains (4) summary

pfam01582
Location:385 → 540

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:124 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 97

Ig; Immunoglobulin domain
XM_006495741.1 → XP_006495804.1 interleukin-1 receptor-like 1 isoform X1

See identical proteins and their annotated locations for XP_006495804.1

UniProtKB/Swiss-Prot

P14719, Q05208

Related

ENSMUSP00000054914.8, ENSMUST00000053043.8

Conserved Domains (4) summary

pfam01582
Location:385 → 540

TIR; TIR domain

cd00096
Location:37 → 42

Ig; Ig strand B [structural motif]

cd05757
Location:124 → 210

Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:33 → 97

Ig; Immunoglobulin domain