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CDC42BPA CDC42 binding protein kinase alpha [ Homo sapiens (human) ]

Gene ID: 8476, updated on 10-Nov-2018

Summary

Official Symbol
CDC42BPAprovided by HGNC
Official Full Name
CDC42 binding protein kinase alphaprovided by HGNC
Primary source
HGNC:HGNC:1737
See related
Ensembl:ENSG00000143776 MIM:603412; Vega:OTTHUMG00000037618
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRCK; MRCKA; PK428
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]
Expression
Ubiquitous expression in testis (RPKM 11.8), kidney (RPKM 9.4) and 25 other tissues See more
Orthologs

Genomic context

See CDC42BPA in Genome Data Viewer
Location:
1q42.13
Exon count:
42
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (226989865..227318502, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (227177566..227506193, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985354 Neighboring gene glucose-dependent insulinotropic receptor-like Neighboring gene coenzyme Q8A Neighboring gene cathepsin B pseudogene Neighboring gene ubiquitin like modifier activating enzyme 5 pseudogene Neighboring gene phosphatidylinositol 4-kinase type 2 beta pseudogene Neighboring gene long intergenic non-protein coding RNA 1641 Neighboring gene nuclear casein kinase and cyclin dependent kinase substrate 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23347, KIAA0451, DKFZp686L1738, DKFZp686P1738

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actomyosin IDA
Inferred from Direct Assay
more info
PubMed 
cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase MRCK alpha
Names
CDC42 binding protein kinase alpha (DMPK-like)
CDC42 binding protein kinase beta
myotonic dystrophy kinase-related CDC42-binding protein kinase alpha
myotonic dystrophy protein kinase-like alpha
ser-thr protein kinase PK428
ser-thr protein kinase related to the myotonic dystrophy protein kinase
NP_003598.2
NP_055641.3
XP_005273374.1
XP_005273375.1
XP_005273377.1
XP_005273378.1
XP_005273379.1
XP_005273381.1
XP_006711897.1
XP_006711898.1
XP_011542608.1
XP_011542609.1
XP_011542610.1
XP_011542611.1
XP_016858067.1
XP_016858068.1
XP_016858069.1
XP_016858070.1
XP_016858071.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366010.1NP_001352939.1  serine/threonine-protein kinase MRCK alpha isoform D

    Status: REVIEWED

    Source sequence(s)
    AB208968, AL353689, AL627308, BC136333
    Conserved Domains (7) summary
    smart00285
    Location:15301564
    PBD; P21-Rho-binding domain
    COG0419
    Location:442979
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00029
    Location:9721021
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10311165
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:11911455
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  2. NM_001366011.1NP_001352940.1  serine/threonine-protein kinase MRCK alpha isoform E

    Status: REVIEWED

    Source sequence(s)
    AL353689, AL627308, BC136333
    Conserved Domains (7) summary
    smart00285
    Location:15381572
    PBD; P21-Rho-binding domain
    COG0419
    Location:442944
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00029
    Location:9801029
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10391173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:11991463
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  3. NM_001366019.1NP_001352948.1  serine/threonine-protein kinase MRCK alpha isoform C

    Status: REVIEWED

    Source sequence(s)
    AL353689, AL451047, AL627308
    Conserved Domains (6) summary
    COG0419
    Location:432941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00029
    Location:10131062
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10721206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12321496
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  4. NM_003607.3NP_003598.2  serine/threonine-protein kinase MRCK alpha isoform B

    See identical proteins and their annotated locations for NP_003598.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) encodes the longer isoform (B).
    Source sequence(s)
    AJ518975, AL353689, AL627308, BC050335, BF765241, BQ232716, BX648219
    Consensus CDS
    CCDS1558.1
    UniProtKB/Swiss-Prot
    Q5VT25
    Related
    ENSP00000355731.3, OTTHUMP00000035727, ENST00000366769.7, OTTHUMT00000091696
    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10001049
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10591193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12191483
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  5. NM_014826.4NP_055641.3  serine/threonine-protein kinase MRCK alpha isoform A

    See identical proteins and their annotated locations for NP_055641.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) lacks a coding segment compared to variant B, resulting in an isoform (A) that lacks an internal region, as compared to isoform B.
    Source sequence(s)
    AJ518976, AL353689, AL627308, BC050335, BF765241, BQ232716, BX648219
    Consensus CDS
    CCDS1559.1
    UniProtKB/Swiss-Prot
    Q5VT25
    Related
    ENSP00000355729.3, OTTHUMP00000035728, ENST00000366767.7, OTTHUMT00000091697
    Conserved Domains (7) summary
    pfam08826
    Location:800860
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:919968
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:9781112
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:11381402
    CNH; CNH domain
    pfam15619
    Location:447614
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    226989865..227318502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002580.2XP_016858069.1  serine/threonine-protein kinase MRCK alpha isoform X13

  2. XM_011544306.3XP_011542608.1  serine/threonine-protein kinase MRCK alpha isoform X1

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10641113
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:11231257
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12831547
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  3. XM_017002581.2XP_016858070.1  serine/threonine-protein kinase MRCK alpha isoform X15

  4. XM_017002579.2XP_016858068.1  serine/threonine-protein kinase MRCK alpha isoform X13

  5. XM_005273324.3XP_005273381.1  serine/threonine-protein kinase MRCK alpha isoform X14

    UniProtKB/Swiss-Prot
    Q5VT25
    Related
    ENSP00000335341.6, OTTHUMP00000035729, ENST00000334218.9, OTTHUMT00000091698
    Conserved Domains (6) summary
    COG0419
    Location:432941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00029
    Location:10131062
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10721206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12321496
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  6. XM_005273320.4XP_005273377.1  serine/threonine-protein kinase MRCK alpha isoform X7

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10131062
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10721206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12321496
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  7. XM_011544309.3XP_011542611.1  serine/threonine-protein kinase MRCK alpha isoform X11

    Conserved Domains (7) summary
    pfam08826
    Location:800860
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:9831032
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10421176
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12021466
    CNH; CNH domain
    pfam15619
    Location:447614
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
  8. XM_005273321.4XP_005273378.1  serine/threonine-protein kinase MRCK alpha isoform X9

    UniProtKB/Swiss-Prot
    Q5VT25
    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10001049
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10591193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12191483
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  9. XM_005273322.4XP_005273379.1  serine/threonine-protein kinase MRCK alpha isoform X12

    UniProtKB/Swiss-Prot
    Q5VT25
    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10351084
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10941228
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12541518
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  10. XM_006711834.4XP_006711897.1  serine/threonine-protein kinase MRCK alpha isoform X4

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10351084
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10941228
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12541518
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  11. XM_017002578.2XP_016858067.1  serine/threonine-protein kinase MRCK alpha isoform X10

  12. XM_005273318.4XP_005273375.1  serine/threonine-protein kinase MRCK alpha isoform X3

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10481097
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:11071241
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12671531
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  13. XM_006711835.4XP_006711898.1  serine/threonine-protein kinase MRCK alpha isoform X6

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10161065
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10751209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12351499
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  14. XM_005273317.4XP_005273374.1  serine/threonine-protein kinase MRCK alpha isoform X2

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10511100
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:11101244
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12701534
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  15. XM_011544307.3XP_011542609.1  serine/threonine-protein kinase MRCK alpha isoform X5

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00029
    Location:10291078
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01243
    Location:10881222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12481512
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  16. XM_011544308.3XP_011542610.1  serine/threonine-protein kinase MRCK alpha isoform X8

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:481791
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:11231257
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10641114
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12831547
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  17. XM_017002582.2XP_016858071.1  serine/threonine-protein kinase MRCK alpha isoform X16

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