Conserved Protein Domain Family
PH_MRCK

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cd01243: PH_MRCK 
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Statistics
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PSSM-Id: 269949
View PSSM: cd01243
Aligned: 18 rows
Threshold Bit Score: 205.994
Threshold Setting Gi: 320167897
Created: 4-Feb-2003
Updated: 2-Mar-2014
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAC02941     1072 PLGIDPQKGVGTAYEGHVriPKPAGVKKGWQRALAVVCDFKLFLYDIaeg---kasQPSSVISQVIDMRDEEFSVSSVlA 1148 Norway rat
AAB96643     1025 PLGIDPTRGIGTAYEGYVkvPKSGVIKRGWIRQFVVVCDFKLFLYDIspd---rcaLPSVSVSQVLDMRDPEFSVGSVrE 1101 fruit fly
NP_504599    1016 PLGIDPTRGVGTAYEGLVktPRAGGVRKGWQTAYVVVCDFKLYLYDCtvdrqnkmqDVKNEIRLVLDMRDPDFTVCGVsE 1095 Caenorhabditi...
AAT67172      937 ALGVHPETGTGTAYEGFLsvPRPSGVRRGWQRVFAALSDSRLLLFDApdl---rlsPPSGALLQVLDLRDPQFSATPVlA 1013 human
EFX80720     1071 PLGIDPTRGIGTAYEGYVkvPKPGGVKKGWLRQFVVVCDFKLFLYDIsae---rnaQPSVSVSQVLDMRDEQFEVSSVrD 1147 common water ...
XP_002406858 1005 PVGIDPTRGVGTAYEGYV--PKLGGVKKGWQRQFVAVCDFKLFLYDLlqe---knvQPAVSASQVLDMRDEEFSVTSVlE 1079 black-legged ...
XP_003739057 1015 LLAIDPTRGVGTAYEGYVkvPKVGGVKKGWQRQFVAVCDFKLFLYDTqq-----enNKCSNFRQVLDMRDPDFMVSAVlE 1089 western preda...
XP_003380283 1195 PLGIDPSRGLGTTYQGLVrvPKPGGLKKGWTSQLLVVCDLKLFLFDCatdrngkptDIAPHASLVLDMRDEDFMVSSVrE 1274 Trichinella s...
XP_003383351  993 PSGIDIHHGVGTACEGWIqvPKPGGVKKGWTRAYAFVCDFKIFCHEPsnd----vhSPANGVFNIFDIRDINFRVSKVtR 1068 Amphimedon qu...
EFW44796     1256 NPRVDPLHGIGTAIQGFLrvPKPGGVRKGWRKQFFVVSDFKIHVFGGdg------dRHQQELAAIIDIRDREFILQSVkQ 1329 Capsaspora ow...
AAC02941     1149 SDVIHASRKDiPCIFRVTASQLSaps--------------dkcSILMLADSETERSKWVGVLSELHKVLKKN 1206 Norway rat
AAB96643     1102 SDVIHAAKKDvPCIFKIKTALIDggl---------------slNTLMLADNESEKSKWVIALGELHRILKRN 1158 fruit fly
NP_504599    1096 ADVIHAQKGDiPKIFRVTTTQILnsssey--------sssskfYTLFMAETEEEKRKWVVALSELKTLLRRS 1159 Caenorhabditis elegans
AAT67172     1014 SDVIHAQSRDlPRIFRVTTSQLAvpp--------------ttcTVLLLAESEGERERWLQVLGELQRLLLDA 1071 human
EFX80720     1148 SDVIHANKKDiPCIFRVSTSMMDppg--------------lrnHLLMLADTESEKTKWVVALNELHRILKRN 1205 common water flea
XP_002406858 1080 SDVIHANRKDiPCIFRVSTSMMDppg--------------lrsQTLMMVDKESEKVKWVDALNELHRILRRN 1137 black-legged tick
XP_003739057 1090 SDVIHANRKDvPCIFRVATSMLDppg--------------lksITLMMVDRESEKNKWVDALAELHRILKRN 1147 western predatory mite
XP_003380283 1275 PDVIHASRKElCCIFRVSASQLHqplagagtggvggggeparsVLLLMAESQHEKQKWVIALNELLRFLRKR 1346 Trichinella spiralis
XP_003383351 1069 QDVIHAGEKLiPTIFKISCTHPTcssv------------gilsELLIRTDNENERDKWVATLDELQKAARQL 1128 Amphimedon queenslandica
EFW44796     1330 EEVIHANRKDvPNIFRICYGTAAqk-----------------qELLVLAADEEEKHRWVIAMNHVVKAARSL 1384 Capsaspora owczarzaki...
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