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Cdc42bpa CDC42 binding protein kinase alpha [ Mus musculus (house mouse) ]

Gene ID: 226751, updated on 11-Apr-2024

Summary

Official Symbol
Cdc42bpaprovided by MGI
Official Full Name
CDC42 binding protein kinase alphaprovided by MGI
Primary source
MGI:MGI:2441841
See related
Ensembl:ENSMUSG00000026490 AllianceGenome:MGI:2441841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DMPK-like; A930014J19Rik
Summary
Predicted to enable several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Acts upstream of or within microtubule cytoskeleton organization and nuclear migration. Located in lamellipodium. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 17.3), cortex adult (RPKM 15.0) and 26 other tissues See more
Orthologs
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Genomic context

See Cdc42bpa in Genome Data Viewer
Location:
1 H4; 1 84.01 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (179787058..179993171)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (179960079..180165606)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E3340 Neighboring gene STARR-positive B cell enhancer ABC_E5865 Neighboring gene STARR-seq mESC enhancer starr_03185 Neighboring gene predicted gene, 31668 Neighboring gene STARR-seq mESC enhancer starr_03186 Neighboring gene STARR-seq mESC enhancer starr_03187 Neighboring gene predicted gene, 50608 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182105294-182105595 Neighboring gene predicted gene, 38331 Neighboring gene STARR-positive B cell enhancer ABC_E2024 Neighboring gene STARR-positive B cell enhancer ABC_E1237 Neighboring gene STARR-seq mESC enhancer starr_03189 Neighboring gene coenzyme Q8A Neighboring gene predicted gene, 57491 Neighboring gene predicted gene, 37336

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC189823

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in actomyosin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actomyosin ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase MRCK alpha
Names
myotonic dystrophy kinase-related CDC-42-binding kinase-alpha
NP_001028457.1
NP_001333733.1
NP_001333734.1
NP_001346470.1
NP_001346471.1
NP_001346472.1
NP_001346473.1
NP_001346474.1
NP_001346475.1
NP_001346476.1
NP_001346477.1
NP_001346478.1
XP_006496865.1
XP_006496866.1
XP_006496867.1
XP_006496869.1
XP_006496870.1
XP_006496872.1
XP_011237104.1
XP_011237105.1
XP_011237106.1
XP_017175608.1
XP_017175618.1
XP_017175619.1
XP_030109369.1
XP_030109370.1
XP_036020077.1
XP_036020080.1
XP_036020088.1
XP_036020093.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033285.1NP_001028457.1  serine/threonine-protein kinase MRCK alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS48466.1
    UniProtKB/TrEMBL
    B2RXX8, E9PVY0
    Related
    ENSMUSP00000106746.2, ENSMUST00000111117.8
    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482782
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10721206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10131063
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12321496
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  2. NM_001346804.1NP_001333733.1  serine/threonine-protein kinase MRCK alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS83649.1
    UniProtKB/Swiss-Prot
    B2RY49, Q3UU96, Q4V9U7, Q6ZQA9, Q8R495
    UniProtKB/TrEMBL
    B2RXX8
    Related
    ENSMUSP00000095059.4, ENSMUST00000097450.10
  3. NM_001346805.1NP_001333734.1  serine/threonine-protein kinase MRCK alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS83650.1
    UniProtKB/TrEMBL
    B2RXX8, H7BX44
    Related
    ENSMUSP00000075980.6, ENSMUST00000076687.12
  4. NM_001359541.1NP_001346470.1  serine/threonine-protein kinase MRCK alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10591193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10001050
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12191483
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  5. NM_001359542.1NP_001346471.1  serine/threonine-protein kinase MRCK alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS87933.1
    UniProtKB/TrEMBL
    A0A1D5RLQ9, B2RXX8
    Related
    ENSMUSP00000148469.2, ENSMUST00000212756.2
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10881222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10291079
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12481512
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  6. NM_001359543.1NP_001346472.1  serine/threonine-protein kinase MRCK alpha isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10751209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10161066
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12351499
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  7. NM_001359544.1NP_001346473.1  serine/threonine-protein kinase MRCK alpha isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    pfam08826
    Location:800860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9781112
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:919969
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11381402
    CNH; CNH domain
  8. NM_001359545.1NP_001346474.1  serine/threonine-protein kinase MRCK alpha isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    D3YYN8
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10391173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:9801030
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11991463
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  9. NM_001359546.1NP_001346475.1  serine/threonine-protein kinase MRCK alpha isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:373872
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10031137
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:944994
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11631427
    CNH; CNH domain
    pfam15796
    Location:461539
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  10. NM_001359547.1NP_001346476.1  serine/threonine-protein kinase MRCK alpha isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    smart00285
    Location:14831517
    PBD; P21-Rho-binding domain
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9841118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:925975
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11441408
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  11. NM_001359548.1NP_001346477.1  serine/threonine-protein kinase MRCK alpha isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    smart00285
    Location:14701504
    PBD; P21-Rho-binding domain
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9711105
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:912962
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11311395
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  12. NM_001359549.1NP_001346478.1  serine/threonine-protein kinase MRCK alpha isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    UniProtKB/TrEMBL
    D3YYN8
    Conserved Domains (7) summary
    smart00285
    Location:14341468
    PBD; P21-Rho-binding domain
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9351069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:876926
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:10951359
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

RNA

  1. NR_153194.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    179787058..179993171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238803.4XP_011237105.1  serine/threonine-protein kinase MRCK alpha isoform X10

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9841118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:11441408
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:923982
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins
  2. XM_030253509.2XP_030109369.1  serine/threonine-protein kinase MRCK alpha isoform X11

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00132
    Location:14651492
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd01243
    Location:9681102
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:909959
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11281392
    CNH; CNH domain
    pfam15796
    Location:425504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  3. XM_030253510.2XP_030109370.1  serine/threonine-protein kinase MRCK alpha isoform X12

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00132
    Location:14521479
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd01243
    Location:9551089
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:896946
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11151379
    CNH; CNH domain
    pfam15796
    Location:425504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  4. XM_011238804.4XP_011237106.1  serine/threonine-protein kinase MRCK alpha isoform X14

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (7) summary
    pfam08826
    Location:696756
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:338757
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00132
    Location:14001427
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd01243
    Location:9031037
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:844894
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:10631327
    CNH; CNH domain
  5. XM_017320119.3XP_017175608.1  serine/threonine-protein kinase MRCK alpha isoform X1

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10881222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12481512
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:10271086
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins
  6. XM_006496802.5XP_006496865.1  serine/threonine-protein kinase MRCK alpha isoform X2

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10751209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10161066
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12351499
    CNH; CNH domain
    pfam15796
    Location:529608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  7. XM_006496803.5XP_006496866.1  serine/threonine-protein kinase MRCK alpha isoform X3

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10721206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10131063
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12321496
    CNH; CNH domain
    pfam15796
    Location:529608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  8. XM_006496804.5XP_006496867.1  serine/threonine-protein kinase MRCK alpha isoform X4

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442943
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10621196
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10031053
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12221486
    CNH; CNH domain
    pfam15796
    Location:529608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  9. XM_006496806.5XP_006496869.1  serine/threonine-protein kinase MRCK alpha isoform X5

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442943
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10491183
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:9901040
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12091473
    CNH; CNH domain
    pfam15796
    Location:529608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  10. XM_006496807.5XP_006496870.1  serine/threonine-protein kinase MRCK alpha isoform X6

    UniProtKB/TrEMBL
    D3YYN8
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10391173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:9801030
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11991463
    CNH; CNH domain
    pfam15796
    Location:529608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  11. XM_036164184.1XP_036020077.1  serine/threonine-protein kinase MRCK alpha isoform X1

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10881222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00780
    Location:12481512
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:10271086
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins
  12. XM_006496809.5XP_006496872.1  serine/threonine-protein kinase MRCK alpha isoform X8

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    pfam08826
    Location:800860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10071141
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:948998
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11671431
    CNH; CNH domain
  13. XM_017320129.3XP_017175618.1  serine/threonine-protein kinase MRCK alpha isoform X9

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    pfam08826
    Location:800860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9941128
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:935985
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11541418
    CNH; CNH domain
  14. XM_017320130.3XP_017175619.1  serine/threonine-protein kinase MRCK alpha isoform X10

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9841118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:11441408
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:923982
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins
  15. XM_036164187.1XP_036020080.1  serine/threonine-protein kinase MRCK alpha isoform X7

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:373872
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10191153
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:11791443
    CNH; CNH domain
    pfam15796
    Location:461539
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:9581017
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins
  16. XM_036164195.1XP_036020088.1  serine/threonine-protein kinase MRCK alpha isoform X10

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9841118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:11441408
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:923982
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins
  17. XM_036164200.1XP_036020093.1  serine/threonine-protein kinase MRCK alpha isoform X13

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    pfam08826
    Location:731791
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:373792
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9381072
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:10981362
    CNH; CNH domain
    cd20864
    Location:877936
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins
  18. XM_011238802.3XP_011237104.1  serine/threonine-protein kinase MRCK alpha isoform X7

    UniProtKB/TrEMBL
    B2RXX8
    Conserved Domains (6) summary
    COG0419
    Location:373872
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10191153
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00780
    Location:11791443
    CNH; CNH domain
    pfam15796
    Location:461539
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cd20864
    Location:9581017
    C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

RNA

  1. XR_001784122.3 RNA Sequence

  2. XR_001784125.3 RNA Sequence

  3. XR_001784127.3 RNA Sequence