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Cdc42bpa CDC42 binding protein kinase alpha [ Mus musculus (house mouse) ]

Gene ID: 226751, updated on 3-Feb-2018

Summary

Official Symbol
Cdc42bpaprovided by MGI
Official Full Name
CDC42 binding protein kinase alphaprovided by MGI
Primary source
MGI:MGI:2441841
See related
Ensembl:ENSMUSG00000026490 Vega:OTTMUSG00000021765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DMPK-like; A930014J19Rik
Expression
Broad expression in cerebellum adult (RPKM 17.3), cortex adult (RPKM 15.0) and 26 other tissues See more
Orthologs

Genomic context

See Cdc42bpa in Genome Data Viewer
Location:
1; 1 H4
Exon count:
43
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (179959968..180165606)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (181891220..182095733)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1 Neighboring gene predicted gene, 31668 Neighboring gene uncharacterized LOC108167749 Neighboring gene predicted gene, 38331 Neighboring gene uncharacterized LOC108167750 Neighboring gene coenzyme Q8A Neighboring gene predicted gene, 37336

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Markers

Homology

Clone Names

  • MGC189823

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actomyosin ISO
Inferred from Sequence Orthology
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase MRCK alpha
Names
myotonic dystrophy kinase-related CDC-42-binding kinase-alpha
NP_001028457.1
XP_006496864.1
XP_006496865.1
XP_006496866.1
XP_006496867.1
XP_006496868.1
XP_006496869.1
XP_006496870.1
XP_006496871.1
XP_006496872.1
XP_006496873.1
XP_006496875.1
XP_006496876.1
XP_011237104.1
XP_011237105.1
XP_011237106.1
XP_017175608.1
XP_017175616.1
XP_017175618.1
XP_017175619.1
XP_017175620.1
XP_017175621.1
XP_017175623.1
XP_017175631.1
XP_017175634.1
XP_017175635.1
XP_017175637.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033285.1NP_001028457.1  serine/threonine-protein kinase MRCK alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS48466.1
    UniProtKB/TrEMBL
    E9PVY0
    Related
    ENSMUSP00000106746.1, OTTMUSP00000024352, ENSMUST00000111117.7, OTTMUST00000051658
    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482782
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10721206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10131063
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12321496
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  2. NM_001346804.1NP_001333733.1  serine/threonine-protein kinase MRCK alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS83649.1
    UniProtKB/Swiss-Prot
    Q3UU96
  3. NM_001346805.1NP_001333734.1  serine/threonine-protein kinase MRCK alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Consensus CDS
    CCDS83650.1
    UniProtKB/TrEMBL
    H7BX44
  4. NM_001359541.1NP_001346470.1  serine/threonine-protein kinase MRCK alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10591193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10001050
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12191483
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  5. NM_001359542.1NP_001346471.1  serine/threonine-protein kinase MRCK alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10881222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10291079
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12481512
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  6. NM_001359543.1NP_001346472.1  serine/threonine-protein kinase MRCK alpha isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10751209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10161066
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12351499
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  7. NM_001359544.1NP_001346473.1  serine/threonine-protein kinase MRCK alpha isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Conserved Domains (6) summary
    pfam08826
    Location:800860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9781112
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:919969
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11381402
    CNH; CNH domain
  8. NM_001359545.1NP_001346474.1  serine/threonine-protein kinase MRCK alpha isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10391173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:9801030
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11991463
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  9. NM_001359546.1NP_001346475.1  serine/threonine-protein kinase MRCK alpha isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Conserved Domains (6) summary
    COG0419
    Location:373872
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10031137
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:944994
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11631427
    CNH; CNH domain
    pfam15796
    Location:461539
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  10. NM_001359547.1NP_001346476.1  serine/threonine-protein kinase MRCK alpha isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Conserved Domains (7) summary
    smart00285
    Location:14831517
    PBD; P21-Rho-binding domain
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9841118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:925975
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11441408
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  11. NM_001359548.1NP_001346477.1  serine/threonine-protein kinase MRCK alpha isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Conserved Domains (7) summary
    smart00285
    Location:14701504
    PBD; P21-Rho-binding domain
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9711105
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:912962
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11311395
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  12. NM_001359549.1NP_001346478.1  serine/threonine-protein kinase MRCK alpha isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436
    Conserved Domains (7) summary
    smart00285
    Location:14341468
    PBD; P21-Rho-binding domain
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9351069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:876926
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:10951359
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

RNA

  1. NR_153194.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125380, AC132436

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    179959968..180165606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320119.1XP_017175608.1  serine/threonine-protein kinase MRCK alpha isoform X1

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482792
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10881222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10291079
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12481512
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  2. XM_006496808.3XP_006496871.1  serine/threonine-protein kinase MRCK alpha isoform X8

    UniProtKB/TrEMBL
    A0A1D5RLQ9
    Related
    ENSMUSP00000148469.1, OTTMUSP00000077845, ENSMUST00000212756.1, OTTMUST00000150151
    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10881222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10291079
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12481512
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  3. XM_017320130.1XP_017175619.1  serine/threonine-protein kinase MRCK alpha isoform X14

    Conserved Domains (8) summary
    pfam08826
    Location:777837
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:1239
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:378678
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:9841118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:925975
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11441408
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  4. XM_011238803.2XP_011237105.1  serine/threonine-protein kinase MRCK alpha isoform X14

    Conserved Domains (8) summary
    pfam08826
    Location:777837
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:1239
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:378678
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:9841118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:925975
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11441408
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  5. XM_011238804.2XP_011237106.1  serine/threonine-protein kinase MRCK alpha isoform X21

    Conserved Domains (8) summary
    pfam08826
    Location:696756
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:1239
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:378633
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00132
    Location:14001427
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cd01243
    Location:9031037
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:844894
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:10631327
    CNH; CNH domain
  6. XM_006496802.3XP_006496865.1  serine/threonine-protein kinase MRCK alpha isoform X2

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482792
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10751209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10161066
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12351499
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  7. XM_017320127.1XP_017175616.1  serine/threonine-protein kinase MRCK alpha isoform X10

    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10751209
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10161066
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12351499
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  8. XM_006496803.3XP_006496866.1  serine/threonine-protein kinase MRCK alpha isoform X3

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482792
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10721206
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10131063
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12321496
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  9. XM_006496805.3XP_006496868.1  serine/threonine-protein kinase MRCK alpha isoform X5

    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10591193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10001050
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12191483
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  10. XM_006496804.3XP_006496867.1  serine/threonine-protein kinase MRCK alpha isoform X4

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482782
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10621196
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10031053
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12221486
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  11. XM_006496806.3XP_006496869.1  serine/threonine-protein kinase MRCK alpha isoform X6

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482782
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10491183
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:9901040
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12091473
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  12. XM_006496807.3XP_006496870.1  serine/threonine-protein kinase MRCK alpha isoform X7

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482782
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10391173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:9801030
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11991463
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  13. XM_006496809.3XP_006496872.1  serine/threonine-protein kinase MRCK alpha isoform X11

    Conserved Domains (7) summary
    pfam08826
    Location:800860
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482737
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10071141
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:948998
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11671431
    CNH; CNH domain
  14. XM_017320129.1XP_017175618.1  serine/threonine-protein kinase MRCK alpha isoform X13

  15. XM_017320131.1XP_017175620.1  serine/threonine-protein kinase MRCK alpha isoform X15

    Conserved Domains (6) summary
    pfam08826
    Location:800860
    DMPK_coil; DMPK coiled coil domain like
    COG0419
    Location:442861
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9781112
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:919969
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11381402
    CNH; CNH domain
  16. XM_006496801.3XP_006496864.1  serine/threonine-protein kinase MRCK alpha isoform X1

    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482792
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10881222
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10291079
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12481512
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  17. XM_017320132.1XP_017175621.1  serine/threonine-protein kinase MRCK alpha isoform X17

    Conserved Domains (6) summary
    COG0419
    Location:373872
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10031137
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:944994
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11631427
    CNH; CNH domain
    pfam15796
    Location:461539
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  18. XM_017320134.1XP_017175623.1  serine/threonine-protein kinase MRCK alpha isoform X18

    Conserved Domains (7) summary
    smart00285
    Location:14831517
    PBD; P21-Rho-binding domain
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9841118
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:925975
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11441408
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  19. XM_017320142.1XP_017175631.1  serine/threonine-protein kinase MRCK alpha isoform X20

    Conserved Domains (7) summary
    smart00285
    Location:14701504
    PBD; P21-Rho-binding domain
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9711105
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:912962
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11311395
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  20. XM_017320146.1XP_017175635.1  serine/threonine-protein kinase MRCK alpha isoform X23

    Conserved Domains (7) summary
    smart00285
    Location:14341468
    PBD; P21-Rho-binding domain
    COG0419
    Location:338837
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:9351069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:1301
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:876926
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:10951359
    CNH; CNH domain
    pfam15796
    Location:426504
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  21. XM_006496810.3XP_006496873.1  serine/threonine-protein kinase MRCK alpha isoform X12

    Related
    ENSMUSP00000095059.3, OTTMUSP00000024385, ENSMUST00000097450.9, OTTMUST00000051702
    Conserved Domains (8) summary
    pfam08826
    Location:881941
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482782
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10591193
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:10001050
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:12191483
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  22. XM_006496812.3XP_006496875.1  serine/threonine-protein kinase MRCK alpha isoform X16

    Conserved Domains (6) summary
    COG0419
    Location:442941
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01243
    Location:10391173
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:9801030
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11991463
    CNH; CNH domain
    pfam15796
    Location:530608
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  23. XM_006496813.3XP_006496876.1  serine/threonine-protein kinase MRCK alpha isoform X19

    Related
    ENSMUSP00000075980.5, OTTMUSP00000024384, ENSMUST00000076687.11, OTTMUST00000051701
    Conserved Domains (7) summary
    pfam08826
    Location:800860
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:77343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:482737
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:9781112
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05623
    Location:4412
    STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
    pfam00130
    Location:919969
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11381402
    CNH; CNH domain
  24. XM_017320145.1XP_017175634.1  serine/threonine-protein kinase MRCK alpha isoform X22

  25. XM_011238802.2XP_011237104.1  serine/threonine-protein kinase MRCK alpha isoform X9

    Conserved Domains (8) summary
    pfam08826
    Location:812872
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:8274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:413723
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd01243
    Location:10191153
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:6336
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:9601010
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:11791443
    CNH; CNH domain
    pfam15796
    Location:461539
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  26. XM_017320148.1XP_017175637.1  serine/threonine-protein kinase MRCK alpha isoform X24

RNA

  1. XR_001784122.1 RNA Sequence

  2. XR_001784123.1 RNA Sequence

  3. XR_001784125.1 RNA Sequence

  4. XR_001784127.1 RNA Sequence

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