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CAMKK1 calcium/calmodulin dependent protein kinase kinase 1 [ Homo sapiens (human) ]

Gene ID: 84254, updated on 2-Oct-2018

Summary

Official Symbol
CAMKK1provided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase kinase 1provided by HGNC
Primary source
HGNC:HGNC:1469
See related
Ensembl:ENSG00000004660 MIM:611411; Vega:OTTHUMG00000090725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKKA
Summary
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 12.8), salivary gland (RPKM 4.6) and 24 other tissues See more
Orthologs

Genomic context

See CAMKK1 in Genome Data Viewer
Location:
17p13.2
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (3860315..3895633, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3763609..3796337, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha E Neighboring gene nonconserved acetylation island sequence 85 enhancer Neighboring gene nuclear cap binding subunit 3 Neighboring gene purinergic receptor P2X 1 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystem (from WikiPathways)
    AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
  • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
    Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • CREB phosphorylation through the activation of CaMKK, organism-specific biosystem (from REACTOME)
    CREB phosphorylation through the activation of CaMKK, organism-specific biosystemTransient increase in intracellular Ca2+ concentration after NMDA receptor activation leads to the activation of the CaMKIV via the activation of CaM-kinase kinase. CaM-kinase kinase and CaMKIV are b...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
  • Post NMDA receptor activation events, organism-specific biosystem (from REACTOME)
    Post NMDA receptor activation events, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34095, DKFZp761M0423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase kinase 1
Names
CAMKK alpha protein
caM-KK 1
caM-KK alpha
caM-kinase IV kinase
caM-kinase kinase 1
caM-kinase kinase alpha
caMKK 1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
calcium/calmodulin-dependent protein kinase kinase alpha
NP_115670.1
NP_757343.2
NP_757344.2
XP_005256874.1
XP_006721651.1
XP_011522333.2
XP_011522334.1
XP_011522335.1
XP_011522337.1
XP_016880709.1
XP_024306764.1
XP_024306765.1
XP_024306766.1
XP_024306767.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032294.2NP_115670.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform a

    See identical proteins and their annotated locations for NP_115670.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AL136576
    Consensus CDS
    CCDS11038.1
    UniProtKB/Swiss-Prot
    Q8N5S9
    Related
    ENSP00000323118.3, OTTHUMP00000115905, ENST00000348335.6, OTTHUMT00000207456
    Conserved Domains (2) summary
    smart00220
    Location:128409
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14200
    Location:127410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
  2. NM_172206.1NP_757343.2  calcium/calmodulin-dependent protein kinase kinase 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and includes a novel 5' coding region compared to variant 1. The encoded isoform (c) has a longer N-terminus than isoform a.
    Source sequence(s)
    AC005940, AF425301
    Consensus CDS
    CCDS86560.1
    UniProtKB/Swiss-Prot
    Q8N5S9
    UniProtKB/TrEMBL
    J3KPJ3
    Related
    ENSP00000371188.2, ENST00000381769.6
  3. NM_172207.2NP_757344.2  calcium/calmodulin-dependent protein kinase kinase 1 isoform b

    See identical proteins and their annotated locations for NP_757344.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional segment in the coding region and uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. It encodes isoform b which is longer, but has a shorter C-terminus compared to isoform a.
    Source sequence(s)
    AC005940, AL136576, BC031647
    Consensus CDS
    CCDS11039.1
    UniProtKB/Swiss-Prot
    Q8N5S9
    Related
    ENSP00000158166.5, OTTHUMP00000115904, ENST00000158166.5, OTTHUMT00000207455
    Conserved Domains (2) summary
    smart00220
    Location:128447
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:127448
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    3860315..3895633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721588.3XP_006721651.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X3

    See identical proteins and their annotated locations for XP_006721651.1

    Conserved Domains (2) summary
    smart00220
    Location:128447
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:127448
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017025220.2XP_016880709.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q8N5S9
    Conserved Domains (2) summary
    smart00220
    Location:128409
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14200
    Location:127410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
  3. XM_005256817.1XP_005256874.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X3

    See identical proteins and their annotated locations for XP_005256874.1

    Conserved Domains (2) summary
    smart00220
    Location:128447
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:127448
    PKc_like; Protein Kinases, catalytic domain
  4. XM_024450997.1XP_024306765.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:36217
    PKc_like; Protein Kinases, catalytic domain
  5. XM_024450998.1XP_024306766.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:1172
    PKc_like; Protein Kinases, catalytic domain
  6. XM_024450996.1XP_024306764.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:154475
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011524033.1XP_011522335.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X7

    See identical proteins and their annotated locations for XP_011522335.1

    Conserved Domains (1) summary
    cl21453
    Location:1172
    PKc_like; Protein Kinases, catalytic domain
  8. XM_024450999.1XP_024306767.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:1172
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011524035.3XP_011522337.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X7

    See identical proteins and their annotated locations for XP_011522337.1

    Conserved Domains (1) summary
    cl21453
    Location:1172
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011524031.3XP_011522333.2  calcium/calmodulin-dependent protein kinase kinase 1 isoform X2

  11. XM_011524032.3XP_011522334.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:154255
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001752661.2 RNA Sequence

  2. XR_001752662.2 RNA Sequence

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