U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Camkk1 calcium/calmodulin-dependent protein kinase kinase 1, alpha [ Mus musculus (house mouse) ]

Gene ID: 55984, updated on 12-May-2024

Summary

Official Symbol
Camkk1provided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase kinase 1, alphaprovided by MGI
Primary source
MGI:MGI:1891766
See related
Ensembl:ENSMUSG00000020785 AllianceGenome:MGI:1891766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Camkk; caMKK 1; caM-KK 1; CaMKKalpha; caMKK alpha; caM-KK alpha
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in activation of protein kinase activity and intracellular signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 25.3), cortex adult (RPKM 17.1) and 15 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Camkk1 in Genome Data Viewer
Location:
11 B4; 11 45.12 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72906869..72932899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73016043..73042073)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7013 Neighboring gene ATPase, Ca++ transporting, ubiquitous Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72820103-72820212 Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72828695-72828896 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 1 Neighboring gene STARR-positive B cell enhancer ABC_E10684 Neighboring gene STARR-positive B cell enhancer ABC_E5246 Neighboring gene nuclear cap binding subunit 3 Neighboring gene STARR-positive B cell enhancer mm9_chr11:72885264-72885564 Neighboring gene STARR-seq mESC enhancer starr_29927 Neighboring gene integrin alpha E, epithelial-associated Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72921846-72921999 Neighboring gene histone H3 associated protein kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase kinase 1
Names
caM-kinase IV kinase
caM-kinase kinase 1
caM-kinase kinase alpha
calcium calmodulin dependent protein kinase kinase alpha
NP_001349770.1
NP_061371.2
XP_006533824.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362841.1NP_001349770.1  calcium/calmodulin-dependent protein kinase kinase 1

    Status: VALIDATED

    Source sequence(s)
    AI843712, AL670399
    Consensus CDS
    CCDS24993.1
    UniProtKB/Swiss-Prot
    Q8VBY2, Q9R054
    Conserved Domains (1) summary
    cd14200
    Location:127410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
  2. NM_018883.3NP_061371.2  calcium/calmodulin-dependent protein kinase kinase 1

    See identical proteins and their annotated locations for NP_061371.2

    Status: VALIDATED

    Source sequence(s)
    AI846603, AK144483, AL670399
    Consensus CDS
    CCDS24993.1
    UniProtKB/Swiss-Prot
    Q8VBY2, Q9R054
    Related
    ENSMUSP00000090613.7, ENSMUST00000092937.13
    Conserved Domains (1) summary
    cd14200
    Location:127410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

RNA

  1. NR_156179.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI843712, AK144483, AL670399
    Related
    ENSMUST00000155720.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72906869..72932899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533761.4XP_006533824.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006533824.1

    UniProtKB/Swiss-Prot
    Q8VBY2, Q9R054
    Conserved Domains (1) summary
    cd14200
    Location:127410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1