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Camkk1 calcium/calmodulin-dependent protein kinase kinase 1, alpha [ Mus musculus (house mouse) ]

Gene ID: 55984, updated on 5-Jan-2023

Summary

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Official Symbol
Camkk1provided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase kinase 1, alphaprovided by MGI
Primary source
MGI:MGI:1891766
See related
Ensembl:ENSMUSG00000020785 AllianceGenome:MGI:1891766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Camkk; caMKK 1; caM-KK 1; CaMKKalpha; caMKK alpha; caM-KK alpha
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in activation of protein kinase activity and intracellular signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 25.3), cortex adult (RPKM 17.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Camkk1 in Genome Data Viewer
Location:
11; 11 B4
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72906869..72932899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73016043..73042073)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ATPase, Ca++ transporting, ubiquitous Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 1 Neighboring gene nuclear cap binding subunit 3 Neighboring gene integrin alpha E, epithelial-associated Neighboring gene histone H3 associated protein kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Constitutively active CaMKKα stimulates skeletal muscle glucose uptake in insulin-resistant mice in vivo. Hinkley JM, et al. Diabetes, 2014 Jan. PMID 24101676, Free PMC Article
  2. Forebrain-specific constitutively active CaMKKα transgenic mice show deficits in hippocampus-dependent long-term memory. Kaitsuka T, et al. Neurobiol Learn Mem, 2011 Sep. PMID 21558011
  3. Novel Ca2+/calmodulin-dependent protein kinase expressed in actively growing mycelia of the basidiomycetous mushroom Coprinus cinereus. Kaneko K, et al. Biochim Biophys Acta, 2009 Jan 1. PMID 18786613
  4. Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes. Shen QW, et al. Am J Physiol Cell Physiol, 2007 Oct. PMID 17687000
  5. Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation. Witczak CA, et al. Diabetes, 2007 May. PMID 17287469

See all (37) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the CaMKK-CaMKIalpha cascade is required for the axonal growth effect of Wnt5a during neuronal polarization.
    Title: Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization.
  2. Data (including data from knockout mice) suggest that up-regulation of Camkk1 and calcium signaling stimulates muscle growth via up-regulation of mTORC1 (mammalian target of rapamycin complex 1) signaling and muscle protein biosynthesis.
    Title: Constitutive activation of CaMKKα signaling is sufficient but not necessary for mTORC1 activation and growth in mouse skeletal muscle.
  3. caCaMKKalpha stimulates glucose uptake additively with insulin, and in insulin-resistant muscle, and alters the phosphorylation of TBC1D1/TBC1D4.
    Title: Constitutively active CaMKKα stimulates skeletal muscle glucose uptake in insulin-resistant mice in vivo.
  4. Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways
    Title: Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.
  5. Data show that CaMKK is the kinase responsible for alpha-lipoic acid induced AMP-activated protein kinase activation in C2C12 myotubes.
    Title: Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes.
  6. In muscles from wild-type mice CaMKKalpha increased in vivo deoxyglucose uptake and AMPKalpha1 and -alpha2 activities 2.5-fold.
    Title: Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation.
  7. ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI
    Title: Calcium activation of ERK mediated by calmodulin kinase I.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase kinase 1
Names
caM-kinase IV kinase
caM-kinase kinase 1
caM-kinase kinase alpha
calcium calmodulin dependent protein kinase kinase alpha
NP_001349770.1
NP_061371.2
XP_006533824.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362841.1 → NP_001349770.1  calcium/calmodulin-dependent protein kinase kinase 1

    Status: VALIDATED

    Source sequence(s)
    AI843712, AL670399
    Consensus CDS
    CCDS24993.1
    UniProtKB/Swiss-Prot
    Q9R054
    Conserved Domains (1) summary
    cd14200
    Location:127 → 410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

  2. NM_018883.3 → NP_061371.2  calcium/calmodulin-dependent protein kinase kinase 1

    See identical proteins and their annotated locations for NP_061371.2

    Status: VALIDATED

    Source sequence(s)
    AI846603, AK144483, AL670399
    Consensus CDS
    CCDS24993.1
    UniProtKB/Swiss-Prot
    Q8VBY2, Q9R054
    Related
    ENSMUSP00000090613.7, ENSMUST00000092937.13
    Conserved Domains (1) summary
    cd14200
    Location:127 → 410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1

RNA

  1. NR_156179.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI843712, AK144483, AL670399
    Related
    ENSMUST00000155720.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72906869..72932899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533761.4 → XP_006533824.1  calcium/calmodulin-dependent protein kinase kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006533824.1

    UniProtKB/Swiss-Prot
    Q8VBY2, Q9R054
    Conserved Domains (1) summary
    cd14200
    Location:127 → 410
    STKc_CaMKK1; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VBY2.1 GenPept UniProtKB/Swiss-Prot:Q8VBY2

Gene LinkOut

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