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INO80B INO80 complex subunit B [ Homo sapiens (human) ]

Gene ID: 83444, updated on 26-Nov-2021

Summary

Official Symbol
INO80Bprovided by HGNC
Official Full Name
INO80 complex subunit Bprovided by HGNC
Primary source
HGNC:HGNC:13324
See related
Ensembl:ENSG00000115274 MIM:616456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IES2; PAPA1; hIes2; PAPA-1; ZNHIT4; HMGA1L4; HMGIYL4; PAP-1BP
Summary
This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in prostate (RPKM 11.1), testis (RPKM 10.6) and 25 other tissues See more
Orthologs
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Genomic context

See INO80B in Genome Data Viewer
Location:
2p13.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (74455087..74457944)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74682214..74685071)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 81 Neighboring gene high mobility group AT-hook 1 pseudogene 8 Neighboring gene WD repeat domain 54 Neighboring gene rhotekin Neighboring gene INO80B-WBP1 readthrough (NMD candidate) Neighboring gene WW domain binding protein 1 Neighboring gene mannosyl-oligosaccharide glucosidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of INO80 complex subunit B (INO80B; ZNHIT4) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough INO80B-WBP1

Readthrough gene: INO80B-WBP1, Included gene: WBP1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome mobilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
INO80 complex subunit B
Names
IES2 homolog
PAP (Pim-1 associated protein) associated protein 1
PAP-1 binding protein
PAP-1-associated protein 1
high mobility group AT-hook 1-like 4
zinc finger HIT domain-containing protein 4
zinc finger, HIT type 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031288.4NP_112578.2  INO80 complex subunit B

    See identical proteins and their annotated locations for NP_112578.2

    Status: REVIEWED

    Source sequence(s)
    BC064425, DB451812
    Consensus CDS
    CCDS1942.2
    UniProtKB/Swiss-Prot
    Q9C086
    Related
    ENSP00000233331.7, ENST00000233331.12
    Conserved Domains (2) summary
    pfam04438
    Location:309336
    zf-HIT; HIT zinc finger
    pfam04795
    Location:211287
    PAPA-1; PAPA-1-like conserved region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    74455087..74457944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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