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WBP1 WW domain binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23559, updated on 12-Oct-2019

Summary

Official Symbol
WBP1provided by HGNC
Official Full Name
WW domain binding protein 1provided by HGNC
Primary source
HGNC:HGNC:12737
See related
Ensembl:ENSG00000239779 MIM:606961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WBP-1
Summary
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in thyroid (RPKM 48.7), prostate (RPKM 45.8) and 25 other tissues See more
Orthologs

Genomic context

See WBP1 in Genome Data Viewer
Location:
2p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (74458438..74460881)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74684996..74688018)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 54 Neighboring gene rhotekin Neighboring gene INO80B-WBP1 readthrough (NMD candidate) Neighboring gene INO80 complex subunit B Neighboring gene mannosyl-oligosaccharide glucosidase Neighboring gene mitochondrial ribosomal protein L53

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15305

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WW domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
WW domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
WW domain-binding protein 1
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012477.4NP_036609.1  WW domain-binding protein 1

    See identical proteins and their annotated locations for NP_036609.1

    Status: REVIEWED

    Source sequence(s)
    BC010012, CN403791
    Consensus CDS
    CCDS1943.1
    UniProtKB/Swiss-Prot
    Q96G27
    Related
    ENSP00000233615.2, ENST00000233615.7
    Conserved Domains (1) summary
    pfam11669
    Location:36142
    WBP-1; WW domain-binding protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    74458438..74460881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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