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WBP1 WW domain binding protein 1 [ Homo sapiens (human) ]

Gene ID: 23559, updated on 9-Jun-2025
Official Symbol
WBP1provided by HGNC
Official Full Name
WW domain binding protein 1provided by HGNC
Primary source
HGNC:HGNC:12737
See related
Ensembl:ENSG00000239779 MIM:606961; AllianceGenome:HGNC:12737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WBP-1
Summary
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in thyroid (RPKM 48.7), prostate (RPKM 45.8) and 25 other tissues See more
Orthologs
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See WBP1 in Genome Data Viewer
Location:
2p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (74458438..74460881)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (74466998..74469448)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74685565..74688008)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:74653567-74654066 Neighboring gene rhotekin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:74663701-74664380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74666515-74667252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16056 Neighboring gene INO80B-WBP1 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11663 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:74684936-74685442 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:74685443-74685950 Neighboring gene INO80 complex subunit B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11664 Neighboring gene mannosyl-oligosaccharide glucosidase Neighboring gene Sharpr-MPRA regulatory region 2309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16061 Neighboring gene mitochondrial ribosomal protein L53

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC15305

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables WW domain binding IEA
Inferred from Electronic Annotation
more info
 
enables WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables WW domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
WW domain-binding protein 1
Names
epididymis secretory sperm binding protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012477.4NP_036609.1  WW domain-binding protein 1

    See identical proteins and their annotated locations for NP_036609.1

    Status: REVIEWED

    Source sequence(s)
    BC010012, CN403791
    Consensus CDS
    CCDS1943.1
    UniProtKB/Swiss-Prot
    B2RE02, O95637, Q96G27
    UniProtKB/TrEMBL
    A0A384P602, B8ZZ95
    Related
    ENSP00000233615.2, ENST00000233615.7
    Conserved Domains (1) summary
    pfam11669
    Location:36142
    WBP-1; WW domain-binding protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    74458438..74460881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    74466998..74469448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)