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ISG20L2 interferon stimulated exonuclease gene 20 like 2 [ Homo sapiens (human) ]

Gene ID: 81875, updated on 23-Nov-2021

Summary

Official Symbol
ISG20L2provided by HGNC
Official Full Name
interferon stimulated exonuclease gene 20 like 2provided by HGNC
Primary source
HGNC:HGNC:25745
See related
Ensembl:ENSG00000143319 MIM:611930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD38
Summary
This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014]
Expression
Broad expression in testis (RPKM 30.7), lymph node (RPKM 8.1) and 24 other tissues See more
Orthologs
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Genomic context

See ISG20L2 in Genome Data Viewer
Location:
1q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156721891..156728766, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156691683..156698558, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nestin Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene methyltransferase like 25B Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene heparin binding growth factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of interferon stimulated exonuclease gene 20kDa-like 2 (ISG20L2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12671, FLJ18628

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-exoribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon-stimulated 20 kDa exonuclease-like 2
Names
interferon stimulated exonuclease gene 20kDa like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303095.1NP_001290024.1  interferon-stimulated 20 kDa exonuclease-like 2

    See identical proteins and their annotated locations for NP_001290024.1

    Status: REVIEWED

    Source sequence(s)
    AW294587, BC000575, CV573712, HY144219
    Consensus CDS
    CCDS1153.1
    UniProtKB/Swiss-Prot
    Q9H9L3
    Conserved Domains (1) summary
    cd06149
    Location:180336
    ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins
  2. NM_001370150.2NP_001357079.1  interferon-stimulated 20 kDa exonuclease-like 2

    Status: REVIEWED

    Source sequence(s)
    AL590666
    Related
    ENSP00000357202.2, ENST00000368219.2
    Conserved Domains (1) summary
    cd06149
    Location:180336
    ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins
  3. NM_001370151.1NP_001357080.1  interferon-stimulated 20 kDa exonuclease-like 2

    Status: REVIEWED

    Source sequence(s)
    AL590666
    Conserved Domains (1) summary
    cd06149
    Location:180336
    ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins
  4. NM_001370152.1NP_001357081.1  interferon-stimulated 20 kDa exonuclease-like 2

    Status: REVIEWED

    Source sequence(s)
    AL590666
    Related
    ENSP00000323424.6, ENST00000313146.10
    Conserved Domains (1) summary
    cd06149
    Location:180336
    ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156721891..156728766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245518.4XP_005245575.1  interferon-stimulated 20 kDa exonuclease-like 2 isoform X2

    Conserved Domains (1) summary
    cl10012
    Location:33121
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030980.1: Suppressed sequence

    Description
    NM_030980.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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