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CDT1 chromatin licensing and DNA replication factor 1 [ Homo sapiens (human) ]

Gene ID: 81620, updated on 11-Apr-2024

Summary

Official Symbol
CDT1provided by HGNC
Official Full Name
chromatin licensing and DNA replication factor 1provided by HGNC
Primary source
HGNC:HGNC:24576
See related
Ensembl:ENSG00000167513 MIM:605525; AllianceGenome:HGNC:24576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUP; RIS2
Summary
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
Expression
Biased expression in bone marrow (RPKM 13.5), placenta (RPKM 2.5) and 9 other tissues See more
Orthologs
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Genomic context

See CDT1 in Genome Data Viewer
Location:
16q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (88803789..88809258)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (94874309..94879778)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88870197..88875666)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene piezo type mechanosensitive ion channel component 1 (Er blood group) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7872 Neighboring gene HSP90AB1 associated lncRNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88810272-88810958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7873 Neighboring gene uncharacterized LOC339059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88829625-88830384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88830385-88831146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88834041-88834626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88834627-88835210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88835211-88835794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88836379-88836962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88836963-88837546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88842592-88843342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88850859-88851772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88856742-88857272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88869451-88870026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88870745-88871628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88871629-88872511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88873249-88873762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88876670-88877205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88878711-88879395 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88879396-88880079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88882597-88883098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88883099-88883598 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:88884193-88885392 Neighboring gene adenine phosphoribosyltransferase Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7882 Neighboring gene uncharacterized LOC107983950 Neighboring gene trafficking protein particle complex subunit 2L

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meier-Gorlin syndrome 4
MedGen: C3151120 OMIM: 613804 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Phosphorylation of Chk1 at position Ser345 is required for HIV-1 Vpr-induced G2/M arrest possibly through signaling of DNA re-replication via Cdt1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication checkpoint signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication preinitiation complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in attachment of mitotic spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated DNA replication initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of nuclear cell cycle DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in response to sorbitol IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA replication factor Cdt1
Names
Double parked, Drosophila, homolog of

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028266.1 RefSeqGene

    Range
    5012..10481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030928.4NP_112190.2  DNA replication factor Cdt1

    See identical proteins and their annotated locations for NP_112190.2

    Status: REVIEWED

    Source sequence(s)
    AB053172, AC092384, BC000137
    Consensus CDS
    CCDS32510.1
    UniProtKB/Swiss-Prot
    Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0, Q9H211
    Related
    ENSP00000301019.4, ENST00000301019.9
    Conserved Domains (2) summary
    cd08674
    Location:168352
    Cdt1_m; The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
    cd08767
    Location:415537
    Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    88803789..88809258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    94874309..94879778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)