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Cdt1 chromatin licensing and DNA replication factor 1 [ Mus musculus (house mouse) ]

Gene ID: 67177, updated on 25-Dec-2022

Summary

Official Symbol
Cdt1provided by MGI
Official Full Name
chromatin licensing and DNA replication factor 1provided by MGI
Primary source
MGI:MGI:1914427
See related
Ensembl:ENSMUSG00000006585 AllianceGenome:MGI:1914427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DUP; Ris2; 2610318F11Rik
Summary
Enables DNA binding activity. Involved in DNA replication checkpoint signaling and regulation of DNA-dependent DNA replication initiation. Acts upstream of or within regulation of nuclear cell cycle DNA replication. Located in nucleus. Is expressed in adrenal medulla; brain ventricular layer; dorsal root ganglion; liver; and trunk mesenchyme derived from neural crest. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 48.2), liver E14.5 (RPKM 44.9) and 21 other tissues See more
Orthologs
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Genomic context

See Cdt1 in Genome Data Viewer
Location:
8; 8 E1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123294754..123299869)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122568015..122573130)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene piezo-type mechanosensitive ion channel component 1 Neighboring gene predicted gene, 26497 Neighboring gene predicted gene, 34847 Neighboring gene adenine phosphoribosyl transferase Neighboring gene galactosamine (N-acetyl)-6-sulfate sulfatase Neighboring gene predicted gene, 34962

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA replication checkpoint signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA replication checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA replication preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in deactivation of mitotic spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
involved_in kinetochore organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chromatin binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated DNA replication initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of nuclear cell cycle DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to sorbitol ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
DNA replication factor Cdt1
Names
double parked homolog
retroviral insertion site 2 protein
retroviral integration site 1
retroviral integration site 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026014.3NP_080290.3  DNA replication factor Cdt1

    See identical proteins and their annotated locations for NP_080290.3

    Status: VALIDATED

    Source sequence(s)
    BC048076
    Consensus CDS
    CCDS22741.1
    UniProtKB/Swiss-Prot
    Q8R4E8, Q8R4E9
    Related
    ENSMUSP00000006760.3, ENSMUST00000006760.3
    Conserved Domains (2) summary
    cd08674
    Location:181364
    Cdt1_m; The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
    cd08767
    Location:427549
    Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123294754..123299869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)