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MYO15B myosin XVB [ Homo sapiens (human) ]

Gene ID: 80022, updated on 4-Nov-2022

Summary

Official Symbol
MYO15Bprovided by HGNC
Official Full Name
myosin XVBprovided by HGNC
Primary source
HGNC:HGNC:14083
See related
Ensembl:ENSG00000266714 AllianceGenome:HGNC:14083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYO15BP
Summary
Predicted to enable ATP binding activity; actin binding activity; and cytoskeletal motor activity. Predicted to be located in brush border; cytoplasm; and cytoskeleton. Predicted to be part of myosin complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum (RPKM 37.9), small intestine (RPKM 33.6) and 22 other tissues See more
Orthologs
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Genomic context

See MYO15B in Genome Data Viewer
Location:
17q25.1
Exon count:
72
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75587800..75626849)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76480978..76520034)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73583881..73622929)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene LLGL scribble cell polarity complex component 2 Neighboring gene Sharpr-MPRA regulatory region 12965 Neighboring gene RecQ like helicase 5 Neighboring gene HNF1 motif-containing MPRA enhancer 181 Neighboring gene small integral membrane protein 5 Neighboring gene small integral membrane protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21606, FLJ22686, FLJ40577, FLJ44494, KIAA1783

General protein information

Preferred Names
myosin XVB
Names
myosin XVB pseudogene
unconventional myosin XVBP pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309242.2NP_001296171.1  myosin XVB isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087749, KF511237
    UniProtKB/Swiss-Prot
    Q96JP2
    UniProtKB/TrEMBL
    Q9H614
    Conserved Domains (10) summary
    cd12068
    Location:24472501
    SH3_MYO15B; Src Homology 3 domain of Myosin XVb
    smart00139
    Location:26052743
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:7171356
    MYSc; Myosin. Large ATPases
    smart00295
    Location:27592955
    B41; Band 4.1 homologues
    cd13201
    Location:29513052
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cl22853
    Location:7341344
    Motor_domain; Myosin and Kinesin motor domain
    pfam00373
    Location:28442955
    FERM_M; FERM central domain
    pfam00784
    Location:15601662
    MyTH4; MyTH4 domain
    cl00936
    Location:165309
    RecX; RecX family
    cl17171
    Location:23492443
    PH-like; Pleckstrin homology-like domain
  2. NM_001395058.1NP_001381987.1  myosin XVB isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087749, KF511237
    Consensus CDS
    CCDS92396.1
    UniProtKB/TrEMBL
    A0A2R8YFM0
    Related
    ENSP00000495242.3, ENST00000645453.3
    Conserved Domains (9) summary
    cd12068
    Location:24852539
    SH3_MYO15B; Src Homology 3 domain of Myosin XVb
    smart00139
    Location:26432781
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:27972993
    B41; Band 4.1 homologues
    PHA03307
    Location:9358
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK12678
    Location:272494
    PRK12678; transcription termination factor Rho; Provisional
    cd13201
    Location:29893090
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14896
    Location:7341382
    MYSc_Myo35; class XXXV myosin, motor domain
    cl02480
    Location:15551700
    MyTH4; MyTH4 domain
    cl17171
    Location:23872481
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    75587800..75626849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025120.3XP_016880609.1  myosin XVB isoform X1

  2. XM_017025123.3XP_016880612.1  myosin XVB isoform X4

  3. XM_017025125.3XP_016880614.1  myosin XVB isoform X6

  4. XM_017025124.3XP_016880613.1  myosin XVB isoform X5

  5. XM_017025122.3XP_016880611.1  myosin XVB isoform X3

  6. XM_017025121.3XP_016880610.1  myosin XVB isoform X2

  7. XM_017025127.3XP_016880616.1  myosin XVB isoform X8

  8. XM_047436788.1XP_047292744.1  myosin XVB isoform X7

  9. XM_047436789.1XP_047292745.1  myosin XVB isoform X10

  10. XM_047436795.1XP_047292751.1  myosin XVB isoform X19

  11. XM_047436796.1XP_047292752.1  myosin XVB isoform X22

  12. XM_047436798.1XP_047292754.1  myosin XVB isoform X26

  13. XM_017025128.3XP_016880617.1  myosin XVB isoform X9

  14. XM_047436792.1XP_047292748.1  myosin XVB isoform X16

  15. XM_017025131.3XP_016880620.1  myosin XVB isoform X13

  16. XM_047436790.1XP_047292746.1  myosin XVB isoform X14

  17. XM_017025129.3XP_016880618.1  myosin XVB isoform X11

  18. XM_047436791.1XP_047292747.1  myosin XVB isoform X15

  19. XM_017025130.3XP_016880619.1  myosin XVB isoform X12

  20. XM_047436793.1XP_047292749.1  myosin XVB isoform X17

  21. XM_047436794.1XP_047292750.1  myosin XVB isoform X18

  22. XM_017025135.3XP_016880624.1  myosin XVB isoform X20

    Related
    ENST00000633867.1
  23. XM_017025136.3XP_016880625.1  myosin XVB isoform X20

  24. XM_017025137.3XP_016880626.1  myosin XVB isoform X21

  25. XM_047436797.1XP_047292753.1  myosin XVB isoform X24

  26. XM_017025138.3XP_016880627.1  myosin XVB isoform X23

  27. XM_017025140.3XP_016880629.1  myosin XVB isoform X25

    Related
    ENSP00000492911.2, ENST00000642007.2
  28. XM_017025143.3XP_016880632.1  myosin XVB isoform X27

  29. XM_024450952.2XP_024306720.1  myosin XVB isoform X28

    Conserved Domains (5) summary
    cd12068
    Location:802856
    SH3_MYO15B; Src Homology 3 domain of Myosin XVb
    smart00139
    Location:9601098
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:11141310
    B41; Band 4.1 homologues
    cd13201
    Location:13061407
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cl17171
    Location:704798
    PH-like; Pleckstrin homology-like domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    76480978..76520034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080847.1: Suppressed sequence

    Description
    NM_001080847.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
  2. NR_003587.2: Suppressed sequence

    Description
    NR_003587.2: This RefSeq was removed because it is now thought that this gene does encode a protein.