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ZNF669 zinc finger protein 669 [ Homo sapiens (human) ]

Gene ID: 79862, updated on 5-Nov-2017
Official Symbol
ZNF669provided by HGNC
Official Full Name
zinc finger protein 669provided by HGNC
Primary source
HGNC:HGNC:25736
See related
Ensembl:ENSG00000188295 Vega:OTTHUMG00000040869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 3.0), testis (RPKM 2.4) and 25 other tissues See more
Orthologs
Location:
1q44
Exon count:
4
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (247099962..247104400, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247263264..247267685, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene zinc finger protein 519 pseudogene Neighboring gene DNA primase subunit 1 pseudogene Neighboring gene zinc finger protein 670 Neighboring gene chromosome 1 open reading frame 229 Neighboring gene fibroblast growth factor receptor 3 pseudogene 6

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12606

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142572.1NP_001136044.1  zinc finger protein 669 isoform 2

    See identical proteins and their annotated locations for NP_001136044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, which results in a protein (isoform 2) that lacks a segment of the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK056020, BC015312, CA447495
    Consensus CDS
    CCDS44345.1
    UniProtKB/Swiss-Prot
    Q96BR6
    Related
    ENSP00000404370.2, OTTHUMP00000227797, ENST00000448299.6, OTTHUMT00000380746
    Conserved Domains (5) summary
    smart00349
    Location:446
    KRAB; krueppel associated box
    COG5048
    Location:92350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:278298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:178202
    zf-H2C2_2; Zinc-finger double domain
  2. NM_024804.2NP_079080.2  zinc finger protein 669 isoform 1

    See identical proteins and their annotated locations for NP_079080.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL627095, BC015312, CA447495
    Consensus CDS
    CCDS31088.1
    UniProtKB/Swiss-Prot
    Q96BR6
    UniProtKB/TrEMBL
    A0A024R5S3
    Related
    ENSP00000342818.6, OTTHUMP00000038562, ENST00000343381.10, OTTHUMT00000098394
    Conserved Domains (5) summary
    smart00349
    Location:90132
    KRAB; krueppel associated box
    COG5048
    Location:178436
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:90129
    KRAB; KRAB box
    pfam13465
    Location:264288
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

    Range
    247099962..247104400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273270.2XP_005273327.1  zinc finger protein 669 isoform X1

    See identical proteins and their annotated locations for XP_005273327.1

    Conserved Domains (3) summary
    COG5048
    Location:55313
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:141165
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005273271.2XP_005273328.1  zinc finger protein 669 isoform X1

    See identical proteins and their annotated locations for XP_005273328.1

    Conserved Domains (3) summary
    COG5048
    Location:55313
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:141165
    zf-H2C2_2; Zinc-finger double domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    248535564..248539974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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