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ZBTB17 zinc finger and BTB domain containing 17 [ Homo sapiens (human) ]

Gene ID: 7709, updated on 23-Dec-2018

Summary

Official Symbol
ZBTB17provided by HGNC
Official Full Name
zinc finger and BTB domain containing 17provided by HGNC
Primary source
HGNC:HGNC:12936
See related
Ensembl:ENSG00000116809 MIM:604084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIZ-1; ZNF60; ZNF151; pHZ-67
Summary
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 10.4), testis (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See ZBTB17 in Genome Data Viewer
Location:
1p36.13
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (15939933..15976132, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16268364..16302627, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC729614 Neighboring gene spen family transcriptional repressor Neighboring gene NFE2L2 motif-containing MPRA enhancer 216 Neighboring gene steroid receptor associated and regulated protein Neighboring gene heat shock protein family B (small) member 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
protein-DNA complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 17
Names
Myc-interacting Zn finger protein-1
zinc finger protein 151 (pHZ-67)
zinc finger protein 60

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242884.1NP_001229813.1  zinc finger and BTB domain-containing protein 17 isoform 1

    See identical proteins and their annotated locations for NP_001229813.1

    Status: VALIDATED

    Source sequence(s)
    AK301896, BC126163, BU634371, DB064089
    Consensus CDS
    CCDS55576.1
    UniProtKB/Swiss-Prot
    Q13105
    Related
    ENSP00000438529.1, ENST00000537142.5
    Conserved Domains (5) summary
    COG5048
    Location:224555
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:534553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:238262
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001287603.1NP_001274532.1  zinc finger and BTB domain-containing protein 17 isoform 3

    See identical proteins and their annotated locations for NP_001274532.1

    Status: VALIDATED

    Source sequence(s)
    AK223618, BC143965, BC143968, DB064089
    Consensus CDS
    CCDS72712.1
    UniProtKB/Swiss-Prot
    Q13105
    UniProtKB/TrEMBL
    Q53EM1
    Related
    ENSP00000364885.2, ENST00000375733.6
    Conserved Domains (7) summary
    smart00225
    Location:25109
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:306637
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:476496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:616635
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:306328
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14109
    BTB; BTB/POZ domain
    pfam13465
    Location:320344
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001287604.1NP_001274533.1  zinc finger and BTB domain-containing protein 17 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK223618, BC143968, DB064089
    UniProtKB/TrEMBL
    Q53EM1
    Conserved Domains (7) summary
    smart00225
    Location:133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:230561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:540559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:230252
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:244268
    zf-H2C2_2; Zinc-finger double domain
    cl02518
    Location:133
    BTB; BTB/POZ domain
  4. NM_001324137.1NP_001311066.1  zinc finger and BTB domain-containing protein 17 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL034555, AL355994
    Conserved Domains (7) summary
    smart00225
    Location:133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:230561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:540559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:230252
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:244268
    zf-H2C2_2; Zinc-finger double domain
    cl02518
    Location:133
    BTB; BTB/POZ domain
  5. NM_001324138.1NP_001311067.1  zinc finger and BTB domain-containing protein 17 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL034555, AL355994
  6. NM_003443.2NP_003434.2  zinc finger and BTB domain-containing protein 17 isoform 2

    See identical proteins and their annotated locations for NP_003434.2

    Status: VALIDATED

    Source sequence(s)
    BC126163, BQ575263, DB064089
    Consensus CDS
    CCDS165.1
    UniProtKB/Swiss-Prot
    Q13105
    Related
    ENSP00000364895.4, ENST00000375743.8
    Conserved Domains (7) summary
    smart00225
    Location:25109
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:306637
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:476496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:616635
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:306328
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14109
    BTB; BTB/POZ domain
    pfam13465
    Location:320344
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    15939933..15976132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245986.2XP_005246043.1  zinc finger and BTB domain-containing protein 17 isoform X1

    Conserved Domains (7) summary
    smart00225
    Location:2565
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:243574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:413433
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:553572
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:243265
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:1466
    BTB; BTB/POZ domain
    pfam13465
    Location:257281
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011542087.3XP_011540389.1  zinc finger and BTB domain-containing protein 17 isoform X3

    See identical proteins and their annotated locations for XP_011540389.1

    Conserved Domains (5) summary
    COG5048
    Location:224555
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:534553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:238262
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011542085.3XP_011540387.1  zinc finger and BTB domain-containing protein 17 isoform X2

    See identical proteins and their annotated locations for XP_011540387.1

    Conserved Domains (7) summary
    smart00225
    Location:133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:230561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:540559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:230252
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:244268
    zf-H2C2_2; Zinc-finger double domain
    cl02518
    Location:133
    BTB; BTB/POZ domain
  4. XM_005245987.2XP_005246044.1  zinc finger and BTB domain-containing protein 17 isoform X2

    See identical proteins and their annotated locations for XP_005246044.1

    Conserved Domains (7) summary
    smart00225
    Location:133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:230561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:400420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:540559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:230252
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:244268
    zf-H2C2_2; Zinc-finger double domain
    cl02518
    Location:133
    BTB; BTB/POZ domain
  5. XM_011542086.2XP_011540388.1  zinc finger and BTB domain-containing protein 17 isoform X3

    See identical proteins and their annotated locations for XP_011540388.1

    Conserved Domains (5) summary
    COG5048
    Location:224555
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:534553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:238262
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017002242.2XP_016857731.1  zinc finger and BTB domain-containing protein 17 isoform X3

    Conserved Domains (5) summary
    COG5048
    Location:224555
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:534553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:238262
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011542088.1XP_011540390.1  zinc finger and BTB domain-containing protein 17 isoform X4

    See identical proteins and their annotated locations for XP_011540390.1

    UniProtKB/Swiss-Prot
    Q13105
    Conserved Domains (5) summary
    COG5048
    Location:224555
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:534553
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:238262
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_001737399.1 RNA Sequence

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