3M8V,3B84,1R28,2Z8H,1BUO,4U77,4EOZ,4CXI


Conserved Protein Domain Family
BTB

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pfam00651: BTB (this model, PSSM-Id:279045 is obsolete and has been replaced by 334194)
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BTB/POZ domain
The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Statistics
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PSSM-Id: 279045
View PSSM: pfam00651
Aligned: 88 rows
Threshold Bit Score: 53.407
Threshold Setting Gi: 1353147
Created: 15-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3M8V_A  24 LNEQRGHG--LFCDVTVIVEd----RKFRAHKNILSASSTYFHQLFSVAg--------------------qVVELSFIRA 77  human
O61932  71 LRDDYSGAr-ELCDVTLRFDd----ESIPAHWVMLAAYSPAFAEKFRKPnk------------------cfVLEMQPLDK 127 Caenorhabditis elegans
Q19838  23 LQAKRRAGdfSTCDVKIQLKt----GFDMVHSVVICAHSDVFSETFDNQrap-----------------yqpFNMTDFDP 81  Caenorhabditis elegans
4U77_A  20 LQNFFNKT--DYCDLTLQFRd---nSQLKVHRLVLSACTDYFNVLEQTCeiv----------------ddaLIMPNEFQA 78  fruit fly
Q10225 296 LNQPSDQY--SFHDAYLQSYt----HRYPVHRAIMCRCEYFLDMLAGPFlesn---------------qelpVLSLPFSS 354 Schizosaccharomyces p...
P40560 264 VFSLMNCP--AYPDVQLMVKnrngaIRIYPCHLAVLSRAEYFKVMFTNNfkekvtyikakhvtgkynsiipQLTLPNCEF 341 Saccharomyces cerevis...
Q8N653 655 MKAYLEGAgaEFCDITLLLDg----HPRPAHKAILAARSSYFEAMFRSFmped---------------gqvNISIGEMVP 715 human
O16313  54 FDEIFTST--DHSDVTLVLDd---gTEFAAHRLILAVRSSFFRAMLYTGfqes---------------hqqLVTLQETNS 113 Caenorhabditis elegans
Q54RA9  35 ksllgefK--KYTDIKIKCGg----QIFPTHRIILANSSEFFGRLLLSDfkes---------------sqsVIELKQPDP 93  Dictyostelium discoid...
Q8LEV3 341 LVKLYSTG--EYSDIKIYLSdh--sLTFQSHKVILSLWSVAFAKMFTNGmses---------------hssTIYLTDVSP 401 thale cress
3M8V_A  78 -E--IFAEILNYIYSSKIVRVr----SDLLDELIKSG-QLLGVKFIAELGVPLSQ 124 human
O61932 128 -T--SVKRVLDYIYFGKVTFR-----LATLHEDLKAI-SYFEIVTLQEDVEKRLV 173 Caenorhabditis elegans
Q19838  82 -D--SVRRVFDWMYSGEIDIP-----ETTIADVLAVA-SYLRVTMLQRQIEQKIL 127 Caenorhabditis elegans
4U77_A  79 -D--VVVPIVNFMYTGTLEFE-----LKMYGKLLRTA-KEMNMTVLLKLLEAHRR 124 fruit fly
Q10225 355 -S--VVEIVLKFLYTDKTDIAp----ELALDVVYVADmLSLDKDRSLKSLASIVI 402 Schizosaccharomyces pombe 972h-
P40560 342 -E--VAEIILRYLYADNTDIP-----WMYAVDVLLLA-DILLEDRLKTIASTIIT 387 Saccharomyces cerevisiae S288c
Q8N653 716 -SrqAFESMLRYIYYGEVNMP-----PEDSLYLFAAP-YYYGFYN--NRLQAYCK 761 human
O16313 114 -V--AFRAVLRYMYTSKIDFAgv--eLDILLEYLSLA-HRYDLIQLMTAISEYFK 162 Caenorhabditis elegans
Q54RA9  94 fN--VFPMVLEFMYDGIIYLS-----PENVIPLLAMS-DHYLIRDLQHLCLLFLD 140 Dictyostelium discoideum AX4
Q8LEV3 402 -E--AFKAMMNFMYSGELNMEdtvnfGTELIHLLFLA-DRFGVVPLHQECCKMLL 452 thale cress
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