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ZNF91 zinc finger protein 91 [ Homo sapiens (human) ]

Gene ID: 7644, updated on 3-Nov-2024

Summary

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Official Symbol
ZNF91provided by HGNC
Official Full Name
zinc finger protein 91provided by HGNC
Primary source
HGNC:HGNC:13166
See related
Ensembl:ENSG00000167232 MIM:603971; AllianceGenome:HGNC:13166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPF7; HTF10
Summary
The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]
Expression
Ubiquitous expression in small intestine (RPKM 3.5), thyroid (RPKM 3.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF91 in Genome Data Viewer
Location:
19p12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23305004..23395471, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23439806..23533334, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23540498..23578273, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 90 pseudogene Neighboring gene vomeronasal 1 receptor 91 pseudogene Neighboring gene uncharacterized LOC124904675 Neighboring gene uncharacterized LOC124904674 Neighboring gene uncharacterized LOC107985285 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:23505725-23506518 Neighboring gene CDC42 effector protein 3 pseudogene 1 Neighboring gene BCL2 interacting protein 3 pseudogene 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:23577675-23578543 Neighboring gene uncharacterized LOC105372335 Neighboring gene long intergenic non-protein coding RNA 1224 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:23597843-23598500 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:23598501-23599156 Neighboring gene vomeronasal 1 receptor 92 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors. Nishimura T, et al. Int Immunol, 2001 Aug. PMID 11470777
  2. Hypoxic exosomal HIF-1α-stabilizing circZNF91 promotes chemoresistance of normoxic pancreatic cancer cells via enhancing glycolysis. Zeng Z, et al. Oncogene, 2021 Sep. PMID 34294845
  3. An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons. Jacobs FM, et al. Nature, 2014 Dec 11. PMID 25274305, Free PMC Article
  4. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. Bellefroid EJ, et al. DNA, 1989 Jul-Aug. PMID 2505992
  5. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1991 May 1. PMID 2023909, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxic exosomal HIF-1alpha-stabilizing circZNF91 promotes chemoresistance of normoxic pancreatic cancer cells via enhancing glycolysis.
    Title: Hypoxic exosomal HIF-1α-stabilizing circZNF91 promotes chemoresistance of normoxic pancreatic cancer cells via enhancing glycolysis.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrotransposon silencing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 91
Names
zinc finger protein 91 (HPF7, HTF10)
zinc finger protein HPF7
zinc finger protein HTF10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300951.2 → NP_001287880.1  zinc finger protein 91 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AC010300, AC016628, AI590336, AK291256, AK300294, DB068854, L11672
    Consensus CDS
    CCDS74322.1
    UniProtKB/Swiss-Prot
    Q05481
    Related
    ENSP00000380272.2, ENST00000397082.2
    Conserved Domains (5) summary
    smart00349
    Location:13 → 55
    KRAB; krueppel associated box
    COG5048
    Location:596 → 1037
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236 → 256
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:13 → 52
    KRAB; KRAB box
    pfam13465
    Location:585 → 609
    zf-H2C2_2; Zinc-finger double domain

  2. NM_003430.4 → NP_003421.2  zinc finger protein 91 isoform 1

    See identical proteins and their annotated locations for NP_003421.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010300, AC016628, AI590336, AK291256, AK300294, DB068854, L11672
    Consensus CDS
    CCDS42541.1
    UniProtKB/Swiss-Prot
    A8K5E1, B7Z6G6, Q05481
    Related
    ENSP00000300619.6, ENST00000300619.12
    Conserved Domains (5) summary
    smart00349
    Location:13 → 73
    KRAB; krueppel associated box
    COG5048
    Location:628 → 1069
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:13 → 52
    KRAB; KRAB box
    pfam13465
    Location:617 → 641
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    23305004..23395471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451693.2 → XP_024307461.1  zinc finger protein 91 isoform X1

    Conserved Domains (1) summary
    smart00349
    Location:13 → 73
    KRAB; krueppel associated box

RNA

  1. XR_007066982.1 RNA Sequence

  2. XR_001753754.3 RNA Sequence

  3. XR_007066980.1 RNA Sequence

  4. XR_007066981.1 RNA Sequence

  5. XR_007066978.1 RNA Sequence

  6. XR_007066979.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    23439806..23533334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321997.1 → XP_054177972.1  zinc finger protein 91 isoform X1

RNA

  1. XR_008485188.1 RNA Sequence

  2. XR_008485186.1 RNA Sequence

  3. XR_008485187.1 RNA Sequence

  4. XR_008485185.1 RNA Sequence

  5. XR_008485184.1 RNA Sequence

  6. XR_008485183.1 RNA Sequence

  7. XR_008485182.1 RNA Sequence

  8. XR_008485181.1 RNA Sequence

  9. XR_008485180.1 RNA Sequence

  10. XR_008485189.1 RNA Sequence

  11. XR_008485190.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05481.2 GenPept UniProtKB/Swiss-Prot:Q05481

Gene LinkOut

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