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ZNF91 zinc finger protein 91 [ Homo sapiens (human) ]

Gene ID: 7644, updated on 4-Jun-2020

Summary

Official Symbol
ZNF91provided by HGNC
Official Full Name
zinc finger protein 91provided by HGNC
Primary source
HGNC:HGNC:13166
See related
Ensembl:ENSG00000167232 MIM:603971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPF7; HTF10
Summary
The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]
Expression
Ubiquitous expression in small intestine (RPKM 3.5), thyroid (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF91 in Genome Data Viewer
Location:
19p12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (23305004..23395527, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23540498..23578269, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 90 pseudogene Neighboring gene vomeronasal 1 receptor 91 pseudogene Neighboring gene uncharacterized LOC107985285 Neighboring gene CDC42 effector protein 3 pseudogene 1 Neighboring gene BCL2 interacting protein 3 pseudogene 8 Neighboring gene uncharacterized LOC105372335 Neighboring gene long intergenic non-protein coding RNA 1224 Neighboring gene vomeronasal 1 receptor 92 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transposon integration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 91
Names
zinc finger protein 91 (HPF7, HTF10)
zinc finger protein HPF7
zinc finger protein HTF10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300951.2NP_001287880.1  zinc finger protein 91 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AC010300, AC016628, AI590336, AK291256, AK300294, DB068854, L11672
    Consensus CDS
    CCDS74322.1
    UniProtKB/Swiss-Prot
    Q05481
    Related
    ENSP00000380272.2, ENST00000397082.2
    Conserved Domains (5) summary
    smart00349
    Location:1355
    KRAB; krueppel associated box
    COG5048
    Location:5961037
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1352
    KRAB; KRAB box
    pfam13465
    Location:585609
    zf-H2C2_2; Zinc-finger double domain
  2. NM_003430.4NP_003421.2  zinc finger protein 91 isoform 1

    See identical proteins and their annotated locations for NP_003421.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010300, AC016628, AI590336, AK291256, AK300294, DB068854, L11672
    Consensus CDS
    CCDS42541.1
    UniProtKB/Swiss-Prot
    Q05481
    Related
    ENSP00000300619.6, ENST00000300619.12
    Conserved Domains (5) summary
    smart00349
    Location:1373
    KRAB; krueppel associated box
    COG5048
    Location:6281069
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268288
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1352
    KRAB; KRAB box
    pfam13465
    Location:617641
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    23305004..23395527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451693.1XP_024307461.1  zinc finger protein 91 isoform X4

    Conserved Domains (1) summary
    smart00349
    Location:1373
    KRAB; krueppel associated box
  2. XM_017027236.1XP_016882725.1  zinc finger protein 91 isoform X2

  3. XM_011528266.2XP_011526568.1  zinc finger protein 91 isoform X3

    See identical proteins and their annotated locations for XP_011526568.1

    Conserved Domains (3) summary
    COG5048
    Location:529970
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:169189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:518542
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011528265.3XP_011526567.1  zinc finger protein 91 isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:5871028
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:576600
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006722880.4XP_006722943.1  zinc finger protein 91 isoform X3

    See identical proteins and their annotated locations for XP_006722943.1

    Conserved Domains (3) summary
    COG5048
    Location:529970
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:169189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:518542
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017027235.1XP_016882724.1  zinc finger protein 91 isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:5871028
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:576600
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_001753756.2 RNA Sequence

  2. XR_001753754.2 RNA Sequence

  3. XR_002958354.1 RNA Sequence

  4. XR_001753755.2 RNA Sequence

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