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UCP3 uncoupling protein 3 [ Homo sapiens (human) ]

Gene ID: 7352, updated on 8-Jul-2021

Summary

Official Symbol
UCP3provided by HGNC
Official Full Name
uncoupling protein 3provided by HGNC
Primary source
HGNC:HGNC:12519
See related
Ensembl:ENSG00000175564 MIM:602044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC25A9
Summary
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See UCP3 in Genome Data Viewer
Location:
11q13.4
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (74000277..74009085, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73711322..73720130, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene family with sequence similarity 91 member A1 pseudogene Neighboring gene C2 domain containing 3 centriole elongation regulator Neighboring gene Sharpr-MPRA regulatory region 9619 Neighboring gene protein phosphatase methylesterase 1 Neighboring gene RNA, 5S ribosomal pseudogene 343

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of uncoupling protein 3 (UCP3, mitochondrial, proton carrier) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidative phosphorylation uncoupler activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive thermogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proton transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
involved_in respiratory gaseous exchange by respiratory system TAS
Traceable Author Statement
more info
PubMed 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
involved_in response to superoxide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mitochondrial uncoupling protein 3
Names
solute carrier family 25 member 9
uncoupling protein 3 (mitochondrial, proton carrier)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011515.1 RefSeqGene

    Range
    5153..13961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003356.4NP_003347.1  mitochondrial uncoupling protein 3 isoform UCP3L

    See identical proteins and their annotated locations for NP_003347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (long) encodes the full length isoform.
    Source sequence(s)
    AP003717, AW295096, BC008392, BU618868, DA876282, U84763
    Consensus CDS
    CCDS8229.1
    UniProtKB/Swiss-Prot
    P55916
    UniProtKB/TrEMBL
    A0A0S2Z4G5
    Related
    ENSP00000323740.4, ENST00000314032.9
    Conserved Domains (2) summary
    PTZ00169
    Location:14302
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:112210
    Mito_carr; Mitochondrial carrier protein
  2. NM_022803.3NP_073714.1  mitochondrial uncoupling protein 3 isoform UCP3S

    See identical proteins and their annotated locations for NP_073714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (short) encodes a protein which is different at the C-terminus from isoform UCP3L. It has an incomplete sixth transmembrane domain and an incomplete purine nucleotide binding domain.
    Source sequence(s)
    AP003717, DA876282, U82818
    Consensus CDS
    CCDS44677.1
    UniProtKB/Swiss-Prot
    P55916
    Related
    ENSP00000392143.2, ENST00000426995.2
    Conserved Domains (1) summary
    pfam00153
    Location:112210
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    74000277..74009085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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