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Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) [ Mus musculus (house mouse) ]

Gene ID: 22229, updated on 29-Jan-2023

Summary

Official Symbol
Ucp3provided by MGI
Official Full Name
uncoupling protein 3 (mitochondrial, proton carrier)provided by MGI
Primary source
MGI:MGI:1099787
See related
Ensembl:ENSMUSG00000032942 AllianceGenome:MGI:1099787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UCP-3; Slc25a9
Summary
Enables oxidative phosphorylation uncoupler activity. Acts upstream of or within fatty acid metabolic process and response to superoxide. Located in mitochondrion. Is expressed in adipose tissue; heart; and skeletal muscle. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 11.6), heart adult (RPKM 10.8) and 10 other tissues See more
Orthologs
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Genomic context

See Ucp3 in Genome Data Viewer
Location:
7 E2; 7 54.36 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100122198..100135639)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100472991..100486432)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase methylesterase 1 Neighboring gene C2 calcium-dependent domain containing 3 Neighboring gene predicted gene 10603 Neighboring gene uncoupling protein 2 (mitochondrial, proton carrier) Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene ribosomal protein S8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidative phosphorylation uncoupler activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidative phosphorylation uncoupler activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive thermogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to superoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to superoxide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitochondrial uncoupling protein 3
Names
solute carrier family 25 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009464.3NP_033490.1  mitochondrial uncoupling protein 3

    See identical proteins and their annotated locations for NP_033490.1

    Status: VALIDATED

    Source sequence(s)
    AC117215
    Consensus CDS
    CCDS21497.1
    UniProtKB/Swiss-Prot
    O88293, P56501
    UniProtKB/TrEMBL
    A0A8C6IBT8, B2RTM2
    Related
    ENSMUSP00000032958.8, ENSMUST00000032958.14
    Conserved Domains (2) summary
    PTZ00169
    Location:13298
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:109206
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100122198..100135639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)